Details of the Target

General Information of Target

Target ID LDTP14467
Target Name Glia maturation factor gamma (GMFG)
Gene Name GMFG
Gene ID 9535
Synonyms
Glia maturation factor gamma; GMF-gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGDDAFVRRPRVGSQIPEKMQKAFDDIAKYFSEKEWEKMKASEKIIYVYMKRKYEAMTK
LGFKATLPPFMRNKRVADFQGNDFDNDPNRGNQVEHPQMTFGRLQGIFPKITPEKPAEEG
NDSKGVPEASGPQNNGKQLRPSGKLNTSEKVNKTSGPKRGKHAWTHRVRERKQLVIYEEI
SDPQEDDE
Target Bioclass
Other
Family
Actin-binding proteins ADF family, GMF subfamily
Uniprot ID
O60234
Ensemble ID
ENST00000597595.6
HGNC ID
HGNC:4374

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y75(5.00)  LDD0260  [1]
STPyne
 Probe Info  		K97(4.79); K119(9.54)  LDD2217  [2]
DBIA
 Probe Info  		C96(1.11)  LDD1508  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C96(0.00); C87(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C96(0.00); C87(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C96(0.00); C87(0.00)  LDD0037  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C96(1.11)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C96(0.88)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C96(0.96)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C96(1.04)  LDD1513  [3]
 LDCM0277  AC18 HEK-293T C96(1.08)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C96(0.80)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C96(1.06)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C96(1.08)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C96(0.93)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C96(1.00)  LDD1522  [3]
 LDCM0286  AC26 HEK-293T C96(0.98)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C96(0.95)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C96(0.91)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C96(1.22)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C96(1.05)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C96(0.87)  LDD1531  [3]
 LDCM0295  AC34 HEK-293T C96(1.09)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C96(0.92)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C96(0.99)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C96(1.23)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C96(0.90)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C96(1.23)  LDD1540  [3]
 LDCM0304  AC42 HEK-293T C96(1.10)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C96(0.98)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C96(0.98)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C96(1.06)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C96(0.93)  LDD1548  [3]
 LDCM0312  AC5 HEK-293T C96(0.73)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C96(0.98)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C96(0.88)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C96(1.03)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C96(1.02)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C96(1.03)  LDD1557  [3]
 LDCM0321  AC58 HEK-293T C96(1.10)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C96(1.01)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C96(1.01)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C96(0.94)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C96(1.07)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C96(0.91)  LDD1568  [3]
 LDCM0248  AKOS034007472 HEK-293T C96(1.12)  LDD1511  [3]
 LDCM0379  CL11 HEK-293T C96(0.63)  LDD1583  [3]
 LDCM0405  CL18 HEK-293T C96(1.04)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C96(0.72)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C96(0.75)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C96(0.62)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C96(0.69)  LDD1615  [3]
 LDCM0419  CL30 HEK-293T C96(1.00)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C96(0.87)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C96(0.87)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C96(0.52)  LDD1626  [3]
 LDCM0424  CL35 HEK-293T C96(0.73)  LDD1628  [3]
 LDCM0432  CL42 HEK-293T C96(1.03)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C96(0.80)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C96(0.89)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C96(0.69)  LDD1639  [3]
 LDCM0437  CL47 HEK-293T C96(0.81)  LDD1641  [3]
 LDCM0445  CL54 HEK-293T C96(0.89)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C96(0.88)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C96(0.92)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C96(0.66)  LDD1651  [3]
 LDCM0450  CL59 HEK-293T C96(0.68)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C96(0.87)  LDD1654  [3]
 LDCM0458  CL66 HEK-293T C96(0.94)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C96(1.09)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C96(0.75)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C96(0.67)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C96(0.82)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C96(0.77)  LDD1667  [3]
 LDCM0471  CL78 HEK-293T C96(0.98)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C96(0.96)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C96(0.70)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C96(1.02)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C96(0.83)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C96(0.82)  LDD1680  [3]
 LDCM0484  CL9 HEK-293T C96(0.69)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C96(0.86)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C96(0.82)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C96(0.86)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C96(0.78)  LDD1691  [3]
 LDCM0490  CL95 HEK-293T C96(0.63)  LDD1693  [3]
 LDCM0022  KB02 Jurkat C96(1.32)  LDD2409  [5]
 LDCM0023  KB03 Jurkat C96(1.23)  LDD2826  [5]
 LDCM0024  KB05 DEL C96(1.54)  LDD3149  [5]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840