Details of the Target

General Information of Target

Target ID LDTP14252
Target Name Mitochondrial inner membrane protease ATP23 homolog (ATP23)
Gene Name ATP23
Gene ID 91419
Synonyms
KUB3; XRCC6BP1; Mitochondrial inner membrane protease ATP23 homolog; EC 3.4.24.-; Ku70-binding protein 3; XRCC6-binding protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRGSRSRTSRMAPPASRAPQMRAAPRPAPVAQPPAAAPPSAVGSSAAAPRQPGLMAQMA
TTAAGVAVGSAVGHTLGHAITGGFSGGSNAEPARPDITYQEPQGTQPAQQQQPCLYEIKQ
FLECAQNQGDIKLCEGFNEVLKQCRLANGLA
Target Bioclass
Enzyme
Family
Peptidase M76 family
Uniprot ID
Q9Y6H3
Ensemble ID
ENST00000300145.4
HGNC ID
HGNC:29452

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C161(0.82)  LDD1508  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C161(0.82)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C25(0.95)  LDD1509  [1]
 LDCM0277  AC18 HEK-293T C161(1.10)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C25(1.02)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C161(0.91)  LDD1518  [1]
 LDCM0284  AC24 HEK-293T C25(0.99)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C161(0.96)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C25(1.06)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C25(1.00)  LDD1529  [1]
 LDCM0293  AC32 HEK-293T C25(1.04)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C161(0.98)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C25(0.95)  LDD1535  [1]
 LDCM0302  AC40 HEK-293T C25(1.15)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C161(1.24)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C25(1.03)  LDD1544  [1]
 LDCM0310  AC48 HEK-293T C25(1.07)  LDD1549  [1]
 LDCM0313  AC50 HEK-293T C161(0.96)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C25(1.00)  LDD1553  [1]
 LDCM0319  AC56 HEK-293T C25(0.99)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C161(1.12)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C25(0.99)  LDD1561  [1]
 LDCM0328  AC64 HEK-293T C25(1.09)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C25(1.05)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C25(1.10)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C25(0.92)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C25(1.19)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C25(0.87)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C25(0.96)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C25(1.23)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C25(1.37)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C25(1.04)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C25(1.32)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C25(0.89)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C25(1.20)  LDD1604  [1]
 LDCM0405  CL18 HEK-293T C161(0.97)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C25(1.17)  LDD1610  [1]
 LDCM0412  CL24 HEK-293T C25(0.98)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C25(1.10)  LDD1617  [1]
 LDCM0419  CL30 HEK-293T C161(1.04)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C25(0.95)  LDD1624  [1]
 LDCM0425  CL36 HEK-293T C25(0.91)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C25(0.94)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C161(0.95)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C25(1.09)  LDD1637  [1]
 LDCM0438  CL48 HEK-293T C25(0.92)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C25(1.01)  LDD1643  [1]
 LDCM0445  CL54 HEK-293T C161(1.00)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C25(1.04)  LDD1649  [1]
 LDCM0451  CL6 HEK-293T C161(1.02)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C25(0.96)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C25(1.10)  LDD1656  [1]
 LDCM0458  CL66 HEK-293T C161(1.03)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C25(1.19)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C25(1.16)  LDD1665  [1]
 LDCM0465  CL72 HEK-293T C25(1.25)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C25(2.57)  LDD1669  [1]
 LDCM0471  CL78 HEK-293T C161(1.27)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C25(1.07)  LDD1675  [1]
 LDCM0478  CL84 HEK-293T C25(1.02)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C25(0.91)  LDD1682  [1]
 LDCM0485  CL90 HEK-293T C161(1.05)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C25(1.00)  LDD1689  [1]
 LDCM0491  CL96 HEK-293T C25(0.93)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C25(1.28)  LDD1695  [1]
 LDCM0625  F8 Ramos C25(3.76)  LDD2187  [5]
 LDCM0573  Fragment11 Ramos C25(20.00)  LDD2190  [5]
 LDCM0576  Fragment14 Ramos C25(0.93)  LDD2193  [5]
 LDCM0586  Fragment28 Ramos C25(0.45)  LDD2198  [5]
 LDCM0566  Fragment4 Ramos C25(0.84)  LDD2184  [5]
 LDCM0569  Fragment7 Ramos C25(1.29)  LDD2186  [5]
 LDCM0022  KB02 Ramos C25(2.37)  LDD2182  [5]
 LDCM0023  KB03 Ramos C25(1.10)  LDD2183  [5]
 LDCM0024  KB05 Ramos C25(1.97)  LDD2185  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Dual specificity protein phosphatase 21 (DUSP21) Protein-tyrosine phosphatase family Q9H596
Lysine-specific demethylase hairless (HR) . O43593
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
B-cell lymphoma 6 protein (BCL6) . P41182
Forkhead box protein H1 (FOXH1) . O75593
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-actinin-3 (ACTN3) Alpha-actinin family Q08043
Autophagy protein 5 (ATG5) ATG5 family Q9H1Y0
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Cleavage stimulation factor subunit 2 tau variant (CSTF2T) . Q9H0L4
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578