Details of the Target

General Information of Target

Target ID LDTP14233
Target Name EMILIN-1 (EMILIN1)
Gene Name EMILIN1
Gene ID 11117
Synonyms
EMI; EMILIN-1; Elastin microfibril interface-located protein 1; Elastin microfibril interfacer 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV
DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY
IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL
RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL
DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV
RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS
ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC
QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL
LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP
TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL
IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA
LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL
NSFISVLETVIGTIEEIKS
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.
Uniprot ID
Q9Y6C2
Ensemble ID
ENST00000380320.9
HGNC ID
HGNC:19880

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCLP1 SNV: p.P609H .
HCC1806 SNV: p.R99C .
HCT15 Deletion: p.L452CfsTer5
SNV: p.S635R;p.G814R		 .
HEC1 Insertion: p.L452AfsTer57 DBIA    Probe Info 
IGR37 SNV: p.A872T .
IGR39 SNV: p.A872T .
IM95 SNV: p.A307T DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.R502C .
JURKAT SNV: p.P902T .
KMCH1 SNV: p.L751F DBIA    Probe Info 
KYSE410 SNV: p.Q536H .
MCC26 SNV: p.E591K .
NCIH1793 SNV: p.L723F .
NCIH196 SNV: p.S491C .
OVCAR4 SNV: p.C12Ter .
RCC10RGB SNV: p.L298F .
SAOS2 SNV: p.S703T DBIA    Probe Info 
SW1271 Insertion: p.S405FfsTer104
SNV: p.S918N		 .
SW1990 SNV: p.R763L .
SW837 SNV: p.A19S .
TOV21G Deletion: p.A21PfsTer44;p.C120GfsTer3
SNV: p.E949D		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C734(1.35)  LDD3338  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C734(0.92)  LDD1507  [2]
 LDCM0215  AC10 HEK-293T C734(1.06)  LDD1508  [2]
 LDCM0237  AC12 HEK-293T C734(1.03)  LDD1510  [2]
 LDCM0276  AC17 HEK-293T C734(0.92)  LDD1515  [2]
 LDCM0277  AC18 HEK-293T C734(1.03)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C734(1.09)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C734(0.90)  LDD1519  [2]
 LDCM0285  AC25 HEK-293T C734(1.01)  LDD1524  [2]
 LDCM0286  AC26 HEK-293T C734(1.02)  LDD1525  [2]
 LDCM0288  AC28 HEK-293T C734(0.92)  LDD1527  [2]
 LDCM0294  AC33 HEK-293T C734(1.05)  LDD1533  [2]
 LDCM0295  AC34 HEK-293T C734(1.03)  LDD1534  [2]
 LDCM0297  AC36 HEK-293T C734(1.05)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C734(0.99)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C734(1.02)  LDD1542  [2]
 LDCM0304  AC42 HEK-293T C734(0.99)  LDD1543  [2]
 LDCM0306  AC44 HEK-293T C734(1.04)  LDD1545  [2]
 LDCM0311  AC49 HEK-293T C734(0.98)  LDD1550  [2]
 LDCM0313  AC50 HEK-293T C734(1.04)  LDD1552  [2]
 LDCM0315  AC52 HEK-293T C734(1.02)  LDD1554  [2]
 LDCM0320  AC57 HEK-293T C734(1.00)  LDD1559  [2]
 LDCM0321  AC58 HEK-293T C734(1.16)  LDD1560  [2]
 LDCM0324  AC60 HEK-293T C734(0.99)  LDD1563  [2]
 LDCM0356  AKOS034007680 HEK-293T C734(1.00)  LDD1570  [2]
 LDCM0369  CL100 HEK-293T C734(0.97)  LDD1573  [2]
 LDCM0372  CL103 HEK-293T C734(1.05)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C734(0.97)  LDD1577  [2]
 LDCM0376  CL107 HEK-293T C734(1.02)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C734(0.96)  LDD1581  [2]
 LDCM0381  CL111 HEK-293T C734(0.96)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C734(0.89)  LDD1586  [2]
 LDCM0385  CL115 HEK-293T C734(0.97)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C734(0.96)  LDD1590  [2]
 LDCM0389  CL119 HEK-293T C734(1.05)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C734(1.01)  LDD1595  [2]
 LDCM0394  CL123 HEK-293T C734(0.92)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C734(0.87)  LDD1599  [2]
 LDCM0398  CL127 HEK-293T C734(1.21)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C734(1.00)  LDD1603  [2]
 LDCM0402  CL15 HEK-293T C734(0.93)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C734(0.92)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C734(0.88)  LDD1608  [2]
 LDCM0405  CL18 HEK-293T C734(1.01)  LDD1609  [2]
 LDCM0408  CL20 HEK-293T C734(1.08)  LDD1612  [2]
 LDCM0415  CL27 HEK-293T C734(1.03)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C734(0.92)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C734(1.01)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C734(1.06)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C734(1.06)  LDD1623  [2]
 LDCM0421  CL32 HEK-293T C734(1.04)  LDD1625  [2]
 LDCM0428  CL39 HEK-293T C734(1.07)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C734(1.00)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C734(0.99)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C734(1.02)  LDD1635  [2]
 LDCM0432  CL42 HEK-293T C734(1.10)  LDD1636  [2]
 LDCM0434  CL44 HEK-293T C734(1.07)  LDD1638  [2]
 LDCM0440  CL5 HEK-293T C734(1.08)  LDD1644  [2]
 LDCM0443  CL52 HEK-293T C734(1.00)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C734(1.04)  LDD1647  [2]
 LDCM0445  CL54 HEK-293T C734(0.89)  LDD1648  [2]
 LDCM0447  CL56 HEK-293T C734(1.04)  LDD1650  [2]
 LDCM0451  CL6 HEK-293T C734(1.03)  LDD1654  [2]
 LDCM0455  CL63 HEK-293T C734(1.20)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C734(0.97)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C734(1.06)  LDD1660  [2]
 LDCM0458  CL66 HEK-293T C734(1.08)  LDD1661  [2]
 LDCM0460  CL68 HEK-293T C734(1.14)  LDD1663  [2]
 LDCM0469  CL76 HEK-293T C734(1.01)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C734(1.05)  LDD1673  [2]
 LDCM0471  CL78 HEK-293T C734(1.10)  LDD1674  [2]
 LDCM0473  CL8 HEK-293T C734(0.79)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C734(1.04)  LDD1677  [2]
 LDCM0481  CL87 HEK-293T C734(1.18)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C734(1.13)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C734(1.05)  LDD1686  [2]
 LDCM0485  CL90 HEK-293T C734(1.10)  LDD1688  [2]
 LDCM0487  CL92 HEK-293T C734(1.05)  LDD1690  [2]
 LDCM0494  CL99 HEK-293T C734(1.03)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C734(1.12)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C734(1.01)  LDD1671  [2]
 LDCM0022  KB02 42-MG-BA C734(1.92)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C734(1.84)  LDD2661  [1]
 LDCM0024  KB05 MV4-11 C734(1.35)  LDD3338  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402