Details of the Target

General Information of Target

Target ID LDTP14204
Target Name Glypican-6 (GPC6)
Gene Name GPC6
Gene ID 10082
Synonyms
Glypican-6 [Cleaved into: Secreted glypican-6]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRV
EWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYG
EVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKST
RAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIV
AAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV
Target Bioclass
Other
Family
Glypican family
Subcellular location
Secreted, extracellular space; Cell membrane
Function
Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling.
Uniprot ID
Q9Y625
Ensemble ID
ENST00000377047.9
HGNC ID
HGNC:4454

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C244(0.36)  LDD2125  [1]
DBIA
 Probe Info  		C266(17.83); C270(17.83)  LDD0080  [2]
IA-alkyne
 Probe Info  		C266(0.00); C244(0.00)  LDD0165  [3]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [4]
AOyne
 Probe Info  		14.50  LDD0443  [5]
NAIA_5
 Probe Info  		C407(0.00); C341(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C266(0.88)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C244(0.99)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C341(1.09)  LDD1512  [7]
 LDCM0278  AC19 HEK-293T C266(1.29)  LDD1517  [7]
 LDCM0280  AC20 HEK-293T C244(0.93)  LDD1519  [7]
 LDCM0282  AC22 HEK-293T C341(1.12)  LDD1521  [7]
 LDCM0287  AC27 HEK-293T C266(1.25)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C244(0.92)  LDD1527  [7]
 LDCM0290  AC3 HEK-293T C266(0.95)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C341(1.05)  LDD1530  [7]
 LDCM0296  AC35 HEK-293T C266(1.07)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C244(0.96)  LDD1536  [7]
 LDCM0299  AC38 HEK-293T C341(1.10)  LDD1538  [7]
 LDCM0301  AC4 HEK-293T C244(1.06)  LDD1540  [7]
 LDCM0305  AC43 HEK-293T C266(1.10)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C244(1.00)  LDD1545  [7]
 LDCM0308  AC46 HEK-293T C341(1.25)  LDD1547  [7]
 LDCM0314  AC51 HEK-293T C266(1.14)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C244(1.01)  LDD1554  [7]
 LDCM0317  AC54 HEK-293T C341(1.16)  LDD1556  [7]
 LDCM0322  AC59 HEK-293T C266(1.14)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C341(1.23)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C244(0.91)  LDD1563  [7]
 LDCM0326  AC62 HEK-293T C341(0.97)  LDD1565  [7]
 LDCM0367  CL1 HEK-293T C244(1.01); C341(1.04)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C341(1.41)  LDD1572  [7]
 LDCM0370  CL101 HEK-293T C244(0.91); C341(1.12)  LDD1574  [7]
 LDCM0374  CL105 HEK-293T C244(0.90); C341(1.00)  LDD1578  [7]
 LDCM0378  CL109 HEK-293T C244(0.95); C341(1.05)  LDD1582  [7]
 LDCM0383  CL113 HEK-293T C244(0.91); C341(0.98)  LDD1587  [7]
 LDCM0387  CL117 HEK-293T C244(1.00); C341(1.10)  LDD1591  [7]
 LDCM0392  CL121 HEK-293T C244(0.95); C341(1.05)  LDD1596  [7]
 LDCM0396  CL125 HEK-293T C244(0.95); C341(1.03)  LDD1600  [7]
 LDCM0400  CL13 HEK-293T C244(1.16); C341(1.02)  LDD1604  [7]
 LDCM0406  CL19 HEK-293T C266(0.84)  LDD1610  [7]
 LDCM0408  CL20 HEK-293T C244(1.17)  LDD1612  [7]
 LDCM0410  CL22 HEK-293T C341(1.20)  LDD1614  [7]
 LDCM0413  CL25 HEK-293T C244(0.98); C341(0.95)  LDD1617  [7]
 LDCM0420  CL31 HEK-293T C266(0.80)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C244(1.18)  LDD1625  [7]
 LDCM0423  CL34 HEK-293T C341(1.14)  LDD1627  [7]
 LDCM0426  CL37 HEK-293T C244(0.91); C341(1.05)  LDD1630  [7]
 LDCM0433  CL43 HEK-293T C266(0.92)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C244(1.07)  LDD1638  [7]
 LDCM0436  CL46 HEK-293T C341(1.25)  LDD1640  [7]
 LDCM0439  CL49 HEK-293T C244(1.00); C341(1.15)  LDD1643  [7]
 LDCM0446  CL55 HEK-293T C266(0.82)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C244(1.16)  LDD1650  [7]
 LDCM0449  CL58 HEK-293T C341(1.19)  LDD1652  [7]
 LDCM0453  CL61 HEK-293T C244(0.92); C341(1.02)  LDD1656  [7]
 LDCM0459  CL67 HEK-293T C266(1.01)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C244(1.23)  LDD1663  [7]
 LDCM0462  CL7 HEK-293T C266(0.79)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C341(1.06)  LDD1666  [7]
 LDCM0466  CL73 HEK-293T C244(0.90); C341(1.14)  LDD1669  [7]
 LDCM0472  CL79 HEK-293T C266(0.93)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C244(1.62)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C244(1.16)  LDD1677  [7]
 LDCM0476  CL82 HEK-293T C341(1.04)  LDD1679  [7]
 LDCM0479  CL85 HEK-293T C244(1.06); C341(0.92)  LDD1682  [7]
 LDCM0486  CL91 HEK-293T C266(0.92)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C244(1.18)  LDD1690  [7]
 LDCM0489  CL94 HEK-293T C341(1.25)  LDD1692  [7]
 LDCM0492  CL97 HEK-293T C244(0.99); C341(1.01)  LDD1695  [7]
 LDCM0022  KB02 HCT 116 C266(17.83); C270(17.83)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C266(20.00); C270(20.00)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C266(20.00); C270(20.00)  LDD0082  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C244(0.36)  LDD2125  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402