Details of the Target

General Information of Target

Target ID LDTP13878
Target Name Angiomotin-like protein 2 (AMOTL2)
Gene Name AMOTL2
Gene ID 51421
Synonyms
KIAA0989; Angiomotin-like protein 2; Leman coiled-coil protein; LCCP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR
EVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGS
EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRSGAW
HFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDY
DPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDL
HHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFE
STIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAPPKKFLTLGSKFRYSGRTQAQTRRAS
ALIDRPAPYFERSSSKRYTMSRSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDE
EEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLP
GYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLL
DDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPL
ALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQE
LEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVRLAARQEDAPMIEPLV
PEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPT
VHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGS
VSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTT
HITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETEI
TPEDGED
Target Bioclass
Other
Family
Angiomotin family
Subcellular location
Recycling endosome
Function
Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Uniprot ID
Q9Y2J4
Ensemble ID
ENST00000249883.10
HGNC ID
HGNC:17812

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K374(0.37)  LDD0274  [1]
DBIA
 Probe Info  		C558(1.57)  LDD3312  [2]
IPM
 Probe Info  		C95(1.99)  LDD1701  [3]
NAIA_4
 Probe Info  		C95(0.00); C500(0.00)  LDD2226  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C95(0.94)  LDD1512  [5]
 LDCM0282  AC22 HEK-293T C95(1.07)  LDD1521  [5]
 LDCM0291  AC30 HEK-293T C95(0.90)  LDD1530  [5]
 LDCM0299  AC38 HEK-293T C95(1.00)  LDD1538  [5]
 LDCM0308  AC46 HEK-293T C95(1.02)  LDD1547  [5]
 LDCM0317  AC54 HEK-293T C95(1.00)  LDD1556  [5]
 LDCM0323  AC6 HEK-293T C95(0.88)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C95(0.96)  LDD1565  [5]
 LDCM0367  CL1 HEK-293T C95(0.95)  LDD1571  [5]
 LDCM0368  CL10 HEK-293T C95(0.89)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C95(1.01)  LDD1573  [5]
 LDCM0370  CL101 HEK-293T C95(0.97)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C95(1.10)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C95(0.96)  LDD1577  [5]
 LDCM0374  CL105 HEK-293T C95(0.98)  LDD1578  [5]
 LDCM0376  CL107 HEK-293T C95(1.11)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C95(0.92)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C95(1.04)  LDD1582  [5]
 LDCM0381  CL111 HEK-293T C95(1.14)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C95(0.94)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C95(0.98)  LDD1587  [5]
 LDCM0385  CL115 HEK-293T C95(1.11)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C95(0.92)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C95(1.00)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C95(1.11)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C95(0.92)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C95(1.02)  LDD1596  [5]
 LDCM0394  CL123 HEK-293T C95(1.02)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C95(0.92)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C95(1.05)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C95(0.91)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C95(0.88)  LDD1603  [5]
 LDCM0400  CL13 HEK-293T C95(1.07)  LDD1604  [5]
 LDCM0402  CL15 HEK-293T C95(1.05)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C95(1.08)  LDD1607  [5]
 LDCM0410  CL22 HEK-293T C95(1.01)  LDD1614  [5]
 LDCM0413  CL25 HEK-293T C95(1.01)  LDD1617  [5]
 LDCM0415  CL27 HEK-293T C95(1.10)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C95(0.90)  LDD1620  [5]
 LDCM0418  CL3 HEK-293T C95(1.04)  LDD1622  [5]
 LDCM0423  CL34 HEK-293T C95(0.94)  LDD1627  [5]
 LDCM0426  CL37 HEK-293T C95(1.05)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C95(1.19)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C95(0.92)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C95(1.04)  LDD1634  [5]
 LDCM0436  CL46 HEK-293T C95(0.96)  LDD1640  [5]
 LDCM0439  CL49 HEK-293T C95(1.00)  LDD1643  [5]
 LDCM0443  CL52 HEK-293T C95(1.05)  LDD1646  [5]
 LDCM0449  CL58 HEK-293T C95(1.05)  LDD1652  [5]
 LDCM0453  CL61 HEK-293T C95(0.96)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C95(1.07)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C95(0.97)  LDD1659  [5]
 LDCM0463  CL70 HEK-293T C95(1.18)  LDD1666  [5]
 LDCM0466  CL73 HEK-293T C95(0.92)  LDD1669  [5]
 LDCM0469  CL76 HEK-293T C95(0.93)  LDD1672  [5]
 LDCM0476  CL82 HEK-293T C95(1.14)  LDD1679  [5]
 LDCM0479  CL85 HEK-293T C95(0.97)  LDD1682  [5]
 LDCM0481  CL87 HEK-293T C95(1.09)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C95(0.94)  LDD1685  [5]
 LDCM0489  CL94 HEK-293T C95(1.12)  LDD1692  [5]
 LDCM0492  CL97 HEK-293T C95(0.98)  LDD1695  [5]
 LDCM0494  CL99 HEK-293T C95(0.92)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C95(1.23)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C95(1.11)  LDD1702  [3]
 LDCM0468  Fragment33 HEK-293T C95(0.97)  LDD1671  [5]
 LDCM0022  KB02 HEK-293T C95(0.95)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C95(0.98)  LDD1497  [5]
 LDCM0024  KB05 HMCB C558(1.57)  LDD3312  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
26S proteasome regulatory subunit 6A (PSMC3) AAA ATPase family P17980
E3 ubiquitin-protein ligase BRE1A (RNF20) BRE1 family Q5VTR2
E3 ubiquitin-protein ligase BRE1B (RNF40) BRE1 family O75150
Glutathione S-transferase Mu 5 (GSTM5) Mu family P46439
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Myotubularin-related protein 6 (MTMR6) Protein-tyrosine phosphatase family Q9Y217
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2) SH3RF family Q8TEC5
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Kinesin-like protein KIF9 (KIF9) Kinesin family Q9HAQ2
Unconventional myosin-Vb (MYO5B) Myosin family Q9ULV0
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 SUMO-protein ligase ZBED1 (ZBED1) . O96006
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear factor interleukin-3-regulated protein (NFIL3) BZIP family Q16649
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Thyroid hormone receptor alpha (THRA) Nuclear hormone receptor family P10827
Golgin-45 (BLZF1) . Q9H2G9
Nuclear autoantigen Sp-100 (SP100) . P23497
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fc receptor-like protein 5 (FCRL5) . Q96RD9
Other
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer metastasis-suppressor 1-like protein (BRMS1L) BRMS1 family Q5PSV4
Bystin (BYSL) Bystin family Q13895
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Cyclin-dependent kinase 2-interacting protein (CINP) CINP family Q9BW66
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain family P63167
Cilium assembly protein DZIP1L (DZIP1L) DZIP C2H2-type zinc-finger protein family Q8IYY4
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) Eukaryotic initiation factor 4E family O60573
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 (GNG5) G protein gamma family P63218
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 20 (KRT20) Intermediate filament family P35900
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Lamin-B2 (LMNB2) Intermediate filament family Q03252
Phakinin (BFSP2) Intermediate filament family Q13515
Keratin-associated protein 10-5 (KRTAP10-5) KRTAP type 10 family P60370
Keratin-associated protein 4-2 (KRTAP4-2) KRTAP type 4 family Q9BYR5
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Pre-mRNA-splicing factor 18 (PRPF18) PRP18 family Q99633
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
Transcription elongation factor A protein 2 (TCEA2) TFS-II family Q15560
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Coiled-coil domain-containing protein 185 (CCDC185) . Q8N715
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
LIM domain transcription factor LMO4 (LMO4) . P61968
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Ras association domain-containing protein 5 (RASSF5) . Q8WWW0
RAS protein activator like-3 (RASAL3) . Q86YV0
Sperm-associated antigen 5 (SPAG5) . Q96R06
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402