Details of the Target

General Information of Target

Target ID LDTP13596
Target Name Signal-transducing adaptor protein 1 (STAP1)
Gene Name STAP1
Gene ID 26228
Synonyms
BRDG1; Signal-transducing adaptor protein 1; STAP-1; BCR downstream-signaling protein 1; Docking protein BRDG1; Stem cell adaptor protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MNLRLCVQALLLLWLSLTAVCGGSLMPLPDGNGLEDGNVRHLVQPRGSRNGPGPWQGGRR
KFRRQRPRLSHKGPMPF
Target Bioclass
Other
Subcellular location
Nucleus
Function In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.
Uniprot ID
Q9ULZ2
Ensemble ID
ENST00000265404.7
HGNC ID
HGNC:24133

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C178(1.55); C269(1.91); C76(0.71)  LDD3339  [1]
IA-alkyne
 Probe Info  		C269(3.35)  LDD2182  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C269(2.11)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C269(1.86)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C269(0.02)  LDD2190  [2]
 LDCM0574  Fragment12 Ramos C269(0.70)  LDD2191  [2]
 LDCM0575  Fragment13 Ramos C269(0.91)  LDD2192  [2]
 LDCM0576  Fragment14 Ramos C269(0.55)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C269(0.73)  LDD2194  [2]
 LDCM0580  Fragment21 Ramos C269(1.01)  LDD2195  [2]
 LDCM0582  Fragment23 Ramos C269(1.18)  LDD2196  [2]
 LDCM0578  Fragment27 Ramos C269(1.06)  LDD2197  [2]
 LDCM0586  Fragment28 Ramos C269(0.57)  LDD2198  [2]
 LDCM0588  Fragment30 Ramos C269(1.42)  LDD2199  [2]
 LDCM0589  Fragment31 Ramos C269(0.84)  LDD2200  [2]
 LDCM0590  Fragment32 Ramos C269(1.06)  LDD2201  [2]
 LDCM0468  Fragment33 Ramos C269(0.85)  LDD2202  [2]
 LDCM0596  Fragment38 Ramos C269(0.79)  LDD2203  [2]
 LDCM0566  Fragment4 Ramos C269(1.33)  LDD2184  [2]
 LDCM0610  Fragment52 Ramos C269(0.82)  LDD2204  [2]
 LDCM0614  Fragment56 Ramos C269(1.17)  LDD2205  [2]
 LDCM0569  Fragment7 Ramos C269(2.78)  LDD2186  [2]
 LDCM0571  Fragment9 Ramos C269(0.89)  LDD2188  [2]
 LDCM0022  KB02 Ramos C269(3.35)  LDD2182  [2]
 LDCM0023  KB03 Ramos C269(0.78)  LDD2183  [2]
 LDCM0024  KB05 NALM-6 C178(1.55); C269(1.91); C76(0.71)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Mast/stem cell growth factor receptor Kit (KIT) Tyr protein kinase family P10721
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
GRIP1-associated protein 1 (GRIPAP1) . Q4V328
SH3 domain-containing kinase-binding protein 1 (SH3KBP1) . Q96B97

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.