Details of the Target

General Information of Target

Target ID LDTP13584
Target Name Frizzled-10 (FZD10)
Gene Name FZD10
Gene ID 11211
Synonyms
Frizzled-10; Fz-10; hFz10; FzE7; CD antigen CD350
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTP
LRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRR
SLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTA
EKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLAL
AGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKG
CTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSV
TKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPK
KPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLP
ITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSF
DSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRR
GALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPF
QLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRK
YQGLEIKSSDQPLTVPVSPKFSTRFHC
Target Type
Clinical trial
Target Bioclass
GPCR
Family
G-protein coupled receptor Fz/Smo family
Subcellular location
Cell membrane
Function
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
TTD ID
T59702
Uniprot ID
Q9ULW2
DrugMap ID
TTP1S2F
Ensemble ID
ENST00000229030.5
HGNC ID
HGNC:4039
ChEMBL ID
CHEMBL4523492

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C192(1.39)  LDD1508  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C192(1.39)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C192(1.30)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C192(1.30)  LDD1518  [1]
 LDCM0284  AC24 HEK-293T C192(1.01)  LDD1523  [1]
 LDCM0286  AC26 HEK-293T C192(1.16)  LDD1525  [1]
 LDCM0293  AC32 HEK-293T C192(1.08)  LDD1532  [1]
 LDCM0295  AC34 HEK-293T C192(1.21)  LDD1534  [1]
 LDCM0302  AC40 HEK-293T C192(1.21)  LDD1541  [1]
 LDCM0304  AC42 HEK-293T C192(1.35)  LDD1543  [1]
 LDCM0310  AC48 HEK-293T C192(1.34)  LDD1549  [1]
 LDCM0313  AC50 HEK-293T C192(1.17)  LDD1552  [1]
 LDCM0319  AC56 HEK-293T C192(1.17)  LDD1558  [1]
 LDCM0321  AC58 HEK-293T C192(1.28)  LDD1560  [1]
 LDCM0328  AC64 HEK-293T C192(1.17)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C192(1.06)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C192(1.12)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C192(1.84)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C192(1.27)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C192(1.39)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C192(1.47)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C192(1.47)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C192(1.10)  LDD1591  [1]
 LDCM0390  CL12 HEK-293T C192(1.15)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C192(1.34)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C192(1.73)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C192(1.16)  LDD1604  [1]
 LDCM0405  CL18 HEK-293T C192(1.22)  LDD1609  [1]
 LDCM0412  CL24 HEK-293T C192(1.25)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C192(0.99)  LDD1617  [1]
 LDCM0419  CL30 HEK-293T C192(1.26)  LDD1623  [1]
 LDCM0425  CL36 HEK-293T C192(1.02)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C192(2.01)  LDD1630  [1]
 LDCM0432  CL42 HEK-293T C192(1.11)  LDD1636  [1]
 LDCM0438  CL48 HEK-293T C192(1.03)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C192(1.14)  LDD1643  [1]
 LDCM0445  CL54 HEK-293T C192(1.06)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C192(1.57)  LDD1654  [1]
 LDCM0452  CL60 HEK-293T C192(1.43)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C192(1.42)  LDD1656  [1]
 LDCM0458  CL66 HEK-293T C192(1.32)  LDD1661  [1]
 LDCM0465  CL72 HEK-293T C192(1.58)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C192(1.42)  LDD1669  [1]
 LDCM0471  CL78 HEK-293T C192(1.42)  LDD1674  [1]
 LDCM0478  CL84 HEK-293T C192(1.06)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C192(1.13)  LDD1682  [1]
 LDCM0485  CL90 HEK-293T C192(1.38)  LDD1688  [1]
 LDCM0491  CL96 HEK-293T C192(1.31)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C192(1.26)  LDD1695  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein disulfide-isomerase (P4HB) Protein disulfide isomerase family P07237
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Hypoxia-inducible lipid droplet-associated protein (HILPDA) . Q9Y5L2

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Otsa-101-dtpa-90y Antibody D1ZG5E

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853