Details of the Target

General Information of Target

Target ID LDTP13553
Target Name Kinesin-like protein KIF26A (KIF26A)
Gene Name KIF26A
Gene ID 26153
Synonyms
KIAA1236; Kinesin-like protein KIF26A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPRASRWPPPLLLLLLPLLLLPPAAPGTRDPPPSPARRALSLAPLAGAGLELQLERRP
EREPPPTPPRERRGPATPGPSYRAPEPGAATQRGPSGRAPRGGSADAAWKHWPESNTEAH
VENITFYQNQEDFSTVSSKEGVMVQTSGKSHAASDAPENLTLLAETADARGRSGSSSRTN
FTILPVGYSLEIATALTSQSGNLASESLHLPSSSSEFDERIAAFQTKSGTASEMGTERAM
GLSEEWTVHSQEATTSAWSPSFLPALEMGELTTPSRKRNSSGPDLSWLHFYRTAASSPLL
DLSSSSESTEKLNNSTGLQSSSVSQTKTMHVATVFTDGGPRTLRSLTVSLGPVSKTEGFP
KDSRIATTSSSVLLSPSAVESRRNSRVTGNPGDEEFIEPSTENEFGLTSLRWQNDSPTFG
EHQLASSSEVQNGSPMSQTETVSRSVAPMRGGEITAHWLLTNSTTSADVTGSSASYPEGV
NASVLTQFSDSTVQSGGSHTALGDRSYSESSSTSSSESLNSSAPRGERSIAGISYGQVRG
TAIEQRTSSDHTDHTYLSSTFTKGERALLSITDNSSSSDIVESSTSYIKISNSSHSEYSS
FFHAQTERSNISSYDGEYAQPSTESPVLHTSNLPSYTPTINMPNTSVVLDTDAEFVSDSS
SSSSSSSSSSSSGPPLPLPSVSQSHHLFSSILPSTRASVHLLKSTSDASTPWSSSPSPLP
VSLTTSTSAPLSVSQTTLPQSSSTPVLPRARETPVTSFQTSTMTSFMTMLHSSQTADLKS
QSTPHQEKVITESKSPSLVSLPTESTKAVTTNSPLPPSLTESSTEQTLPATSTNLAQMSP
TFTTTILKTSQPLMTTPGTLSSTASLVTGPIAVQTTAGKQLSLTHPEILVPQISTEGGIS
TERNRVIVDATTGLIPLTSVPTSAKEMTTKLGVTAEYSPASRSLGTSPSPQTTVVSTAED
LAPKSATFAVQSSTQSPTTVSSSASVNSCAVNPCLHNGECVADNTSRGYHCRCPPSWQGD
DCSVDVNECLSNPCPSTAMCNNTQGSFICKCPVGYQLEKGICNLVRTFVTEFKLKRTFLN
TTVEKHSDLQEVENEITKTLNMCFSALPSYIRSTVHASRESNAVVISLQTTFSLASNVTL
FDLADRMQKCVNSCKSSAEVCQLLGSQRRIFRAGSLCKRKSPECDKDTSICTDLDGVALC
QCKSGYFQFNKMDHSCRACEDGYRLENETCMSCPFGLGGLNCGNPYQLITVVIAAAGGGL
LLILGIALIVTCCRKNKNDISKLIFKSGDFQMSPYAEYPKNPRSQEWGREAIEMHENGST
KNLLQMTDVYYSPTSVRNPELERNGLYPAYTGLPGSRHSCIFPGQYNPSFISDESRRRDY
F
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, KIF26 subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity. Plays a critical role in cerebral cortical development. It probably acts as a microtubule stabilizer that regulates neurite growth and radial migration of cortical excitatory neurons.
Uniprot ID
Q9ULI4
Ensemble ID
ENST00000423312.7
HGNC ID
HGNC:20226

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1802(2.43)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C117(1.12)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C117(0.92); C594(0.91)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C594(0.83)  LDD1510  [2]
 LDCM0270  AC15 HEK-293T C354(0.90)  LDD1513  [2]
 LDCM0276  AC17 HEK-293T C117(1.14)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C117(1.93); C594(1.30)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C594(0.86)  LDD1519  [2]
 LDCM0281  AC21 HEK-293T C117(0.99)  LDD1520  [2]
 LDCM0283  AC23 HEK-293T C354(1.14)  LDD1522  [2]
 LDCM0285  AC25 HEK-293T C117(0.94)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C117(1.13); C594(0.82)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C594(0.92)  LDD1527  [2]
 LDCM0289  AC29 HEK-293T C117(1.11)  LDD1528  [2]
 LDCM0290  AC3 HEK-293T C117(1.01); C594(0.84)  LDD1529  [2]
 LDCM0292  AC31 HEK-293T C354(1.19)  LDD1531  [2]
 LDCM0294  AC33 HEK-293T C117(1.37)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C117(1.01); C594(0.91)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C594(0.92)  LDD1536  [2]
 LDCM0298  AC37 HEK-293T C117(0.89)  LDD1537  [2]
 LDCM0300  AC39 HEK-293T C354(1.15)  LDD1539  [2]
 LDCM0301  AC4 HEK-293T C594(0.98)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C117(1.16)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C117(0.95); C594(0.95)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C594(0.86)  LDD1545  [2]
 LDCM0307  AC45 HEK-293T C117(1.13)  LDD1546  [2]
 LDCM0309  AC47 HEK-293T C354(1.05)  LDD1548  [2]
 LDCM0311  AC49 HEK-293T C117(0.86)  LDD1550  [2]
 LDCM0312  AC5 HEK-293T C117(1.19)  LDD1551  [2]
 LDCM0314  AC51 HEK-293T C117(0.79); C594(0.83)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C594(0.86)  LDD1554  [2]
 LDCM0316  AC53 HEK-293T C117(1.13)  LDD1555  [2]
 LDCM0318  AC55 HEK-293T C354(0.95)  LDD1557  [2]
 LDCM0320  AC57 HEK-293T C117(1.15)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C117(0.77); C594(0.96)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C594(0.96)  LDD1563  [2]
 LDCM0325  AC61 HEK-293T C117(0.99)  LDD1564  [2]
 LDCM0327  AC63 HEK-293T C354(1.11)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C354(1.34)  LDD1568  [2]
 LDCM0248  AKOS034007472 HEK-293T C117(1.04)  LDD1511  [2]
 LDCM0356  AKOS034007680 HEK-293T C117(1.16)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C117(1.15); C354(1.09)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C117(1.08); C354(1.11)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C117(0.81)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C117(0.88)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C117(0.87); C354(1.12)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C117(0.84)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C117(0.90)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C117(0.89); C354(1.06)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C354(0.98)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C117(0.90)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C117(1.03)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C117(1.05); C354(1.06)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C117(0.97)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C117(1.07)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C117(0.98); C354(0.99)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C117(1.10)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C117(1.63)  LDD1593  [2]
 LDCM0392  CL121 HEK-293T C117(1.05); C354(1.01)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C117(0.93)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C117(1.14)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C117(0.98); C354(1.05)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C117(0.77)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C117(1.07)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C117(1.20); C354(1.12)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C117(0.83)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C117(1.20)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C117(1.05)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C117(0.93); C594(1.12)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C117(0.86)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C594(0.97)  LDD1612  [2]
 LDCM0409  CL21 HEK-293T C117(1.01)  LDD1613  [2]
 LDCM0411  CL23 HEK-293T C354(1.37)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C117(0.93); C354(1.38)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C117(1.03)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C117(1.28)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C117(0.82)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C117(1.14)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C117(0.87); C594(1.00)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C594(0.90)  LDD1625  [2]
 LDCM0422  CL33 HEK-293T C117(0.86)  LDD1626  [2]
 LDCM0424  CL35 HEK-293T C354(1.10)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C117(1.04); C354(1.02)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C117(0.91)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C117(1.13)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C117(1.35); C594(0.93)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C594(1.28)  LDD1638  [2]
 LDCM0435  CL45 HEK-293T C117(0.92)  LDD1639  [2]
 LDCM0437  CL47 HEK-293T C354(1.16)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C117(0.96); C354(0.99)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C117(1.01)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C117(1.32)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C117(1.18)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C117(0.83); C594(0.97)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C594(1.24)  LDD1650  [2]
 LDCM0448  CL57 HEK-293T C117(1.16)  LDD1651  [2]
 LDCM0450  CL59 HEK-293T C354(1.04)  LDD1653  [2]
 LDCM0453  CL61 HEK-293T C117(1.05); C354(1.02)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C117(0.82)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C117(0.96)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C117(1.47)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C117(0.85); C594(1.07)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C594(1.12)  LDD1663  [2]
 LDCM0461  CL69 HEK-293T C117(0.96)  LDD1664  [2]
 LDCM0462  CL7 HEK-293T C117(1.12); C594(1.08)  LDD1665  [2]
 LDCM0464  CL71 HEK-293T C354(0.89)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C117(0.97); C354(1.10)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C117(0.82)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C117(1.05)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C117(0.74); C594(1.01)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C594(0.84)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C594(1.06)  LDD1677  [2]
 LDCM0475  CL81 HEK-293T C117(0.91)  LDD1678  [2]
 LDCM0477  CL83 HEK-293T C354(1.01)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C117(1.10); C354(1.29)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C117(0.87)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C117(1.02)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C117(1.05)  LDD1686  [2]
 LDCM0484  CL9 HEK-293T C117(1.11)  LDD1687  [2]
 LDCM0486  CL91 HEK-293T C117(0.76); C594(0.86)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C594(0.83)  LDD1690  [2]
 LDCM0488  CL93 HEK-293T C117(0.95)  LDD1691  [2]
 LDCM0490  CL95 HEK-293T C354(1.22)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C117(1.05); C354(1.09)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C117(0.85)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C117(1.37)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C117(1.12)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C117(0.87)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C117(1.10)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C354(0.98)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C354(1.02)  LDD1497  [2]
 LDCM0024  KB05 NB1 C1802(2.43)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402