Details of the Target

General Information of Target

Target ID LDTP13520
Target Name Transcription factor-like 5 protein (TCFL5)
Gene Name TCFL5
Gene ID 10732
Synonyms
CHA; E2BP1; Transcription factor-like 5 protein; Cha transcription factor; HPV-16 E2-binding protein 1; E2BP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSL
RAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCIL
VITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASK
ETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Putative transcription factor. Isoform 3 may play a role in early spermatogenesis.
Uniprot ID
Q9UL49
Ensemble ID
ENST00000335351.8
HGNC ID
HGNC:11646

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C336(0.92)  LDD1507  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
TFBX
 Probe Info  		N.A.  LDD0148  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C336(0.92)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C336(1.18)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C336(0.98)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C336(0.87)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C336(1.04)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C336(1.10)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C336(0.82)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C336(0.95)  LDD1518  [1]
 LDCM0283  AC23 HEK-293T C336(0.98)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C336(0.92)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C336(1.00)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C336(0.95)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C336(0.73)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C336(0.93)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C336(1.02)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C336(0.94)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C336(1.04)  LDD1535  [1]
 LDCM0300  AC39 HEK-293T C336(1.08)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C336(1.08)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C336(1.05)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C336(0.96)  LDD1544  [1]
 LDCM0309  AC47 HEK-293T C336(1.05)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C336(0.99)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C336(1.13)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C336(1.03)  LDD1553  [1]
 LDCM0318  AC55 HEK-293T C336(0.94)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C336(1.10)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C336(1.17)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C336(1.09)  LDD1561  [1]
 LDCM0327  AC63 HEK-293T C336(0.97)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C336(1.09)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C336(0.97)  LDD1570  [1]
 LDCM0369  CL100 HEK-293T C336(0.74)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C336(1.07)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C336(1.05)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C336(1.07)  LDD1583  [1]
 LDCM0382  CL112 HEK-293T C336(0.95)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C336(1.02)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C336(1.08)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C336(0.96)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C336(0.89)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C336(1.41)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C336(0.99)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C336(1.57)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C336(1.51)  LDD1610  [1]
 LDCM0411  CL23 HEK-293T C336(1.23)  LDD1615  [1]
 LDCM0416  CL28 HEK-293T C336(1.17)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C336(0.97)  LDD1621  [1]
 LDCM0419  CL30 HEK-293T C336(1.58)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C336(1.50)  LDD1624  [1]
 LDCM0424  CL35 HEK-293T C336(1.04)  LDD1628  [1]
 LDCM0429  CL4 HEK-293T C336(0.99)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C336(1.23)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C336(1.05)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C336(1.32)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C336(1.38)  LDD1637  [1]
 LDCM0437  CL47 HEK-293T C336(1.10)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C336(1.06)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C336(1.18)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C336(1.23)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C336(1.25)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C336(1.60)  LDD1649  [1]
 LDCM0450  CL59 HEK-293T C336(1.12)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C336(1.12)  LDD1654  [1]
 LDCM0456  CL64 HEK-293T C336(1.14)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C336(1.13)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C336(0.33)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C336(1.46)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C336(1.18)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C336(1.01)  LDD1667  [1]
 LDCM0469  CL76 HEK-293T C336(1.02)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C336(1.05)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C336(1.21)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C336(1.23)  LDD1675  [1]
 LDCM0477  CL83 HEK-293T C336(1.02)  LDD1680  [1]
 LDCM0482  CL88 HEK-293T C336(0.87)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C336(0.99)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C336(1.05)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C336(1.05)  LDD1689  [1]
 LDCM0490  CL95 HEK-293T C336(1.19)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255