Details of the Target

General Information of Target

Target ID LDTP13405
Target Name Zinc finger protein 180 (ZNF180)
Gene Name ZNF180
Gene ID 7733
Synonyms
Zinc finger protein 180; HHZ168
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQ
VHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFE
CVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFE
TVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDL
VYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASR
FLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWP
TKLVKNCFLPLREYFKYFSTELTSSL
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9UJW8
Ensemble ID
ENST00000221327.8
HGNC ID
HGNC:12970

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C619(1.65)  LDD3380  [1]
Acrolein
 Probe Info  		N.A.  LDD0224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C619(1.02); C42(1.08)  LDD1507  [3]
 LDCM0237  AC12 HEK-293T C619(0.90)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C619(0.82)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C619(0.94); C42(0.97)  LDD1515  [3]
 LDCM0280  AC20 HEK-293T C619(0.72)  LDD1519  [3]
 LDCM0283  AC23 HEK-293T C619(1.30)  LDD1522  [3]
 LDCM0285  AC25 HEK-293T C619(1.09); C42(1.07)  LDD1524  [3]
 LDCM0288  AC28 HEK-293T C619(0.77)  LDD1527  [3]
 LDCM0292  AC31 HEK-293T C619(0.98)  LDD1531  [3]
 LDCM0294  AC33 HEK-293T C619(1.01); C42(1.12)  LDD1533  [3]
 LDCM0297  AC36 HEK-293T C619(0.79)  LDD1536  [3]
 LDCM0300  AC39 HEK-293T C619(0.89)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C619(0.90)  LDD1540  [3]
 LDCM0303  AC41 HEK-293T C619(1.05); C42(1.19)  LDD1542  [3]
 LDCM0306  AC44 HEK-293T C619(0.91)  LDD1545  [3]
 LDCM0309  AC47 HEK-293T C619(1.10)  LDD1548  [3]
 LDCM0311  AC49 HEK-293T C619(0.82); C42(1.00)  LDD1550  [3]
 LDCM0315  AC52 HEK-293T C619(0.89)  LDD1554  [3]
 LDCM0318  AC55 HEK-293T C619(1.00)  LDD1557  [3]
 LDCM0320  AC57 HEK-293T C619(1.10); C42(1.02)  LDD1559  [3]
 LDCM0324  AC60 HEK-293T C619(0.89)  LDD1563  [3]
 LDCM0327  AC63 HEK-293T C619(1.17)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C619(0.84)  LDD1568  [3]
 LDCM0356  AKOS034007680 HEK-293T C619(1.00); C42(1.03)  LDD1570  [3]
 LDCM0379  CL11 HEK-293T C619(1.00)  LDD1583  [3]
 LDCM0404  CL17 HEK-293T C619(1.08); C42(1.02)  LDD1608  [3]
 LDCM0408  CL20 HEK-293T C619(0.86)  LDD1612  [3]
 LDCM0411  CL23 HEK-293T C619(1.22)  LDD1615  [3]
 LDCM0417  CL29 HEK-293T C619(0.96); C42(0.99)  LDD1621  [3]
 LDCM0421  CL32 HEK-293T C619(0.92)  LDD1625  [3]
 LDCM0424  CL35 HEK-293T C619(0.99)  LDD1628  [3]
 LDCM0431  CL41 HEK-293T C619(0.97); C42(0.99)  LDD1635  [3]
 LDCM0434  CL44 HEK-293T C619(0.98)  LDD1638  [3]
 LDCM0437  CL47 HEK-293T C619(0.79)  LDD1641  [3]
 LDCM0440  CL5 HEK-293T C619(1.23); C42(1.03)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C619(1.10); C42(1.10)  LDD1647  [3]
 LDCM0447  CL56 HEK-293T C619(0.94)  LDD1650  [3]
 LDCM0450  CL59 HEK-293T C619(0.98)  LDD1653  [3]
 LDCM0457  CL65 HEK-293T C619(0.96); C42(1.04)  LDD1660  [3]
 LDCM0460  CL68 HEK-293T C619(0.79)  LDD1663  [3]
 LDCM0464  CL71 HEK-293T C619(0.99)  LDD1667  [3]
 LDCM0470  CL77 HEK-293T C619(1.24); C42(0.95)  LDD1673  [3]
 LDCM0473  CL8 HEK-293T C619(1.10)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C619(0.80)  LDD1677  [3]
 LDCM0477  CL83 HEK-293T C619(0.72)  LDD1680  [3]
 LDCM0483  CL89 HEK-293T C619(0.94); C42(0.93)  LDD1686  [3]
 LDCM0487  CL92 HEK-293T C619(0.85)  LDD1690  [3]
 LDCM0490  CL95 HEK-293T C619(0.94)  LDD1693  [3]
 LDCM0022  KB02 A2780 C619(2.91)  LDD2254  [1]
 LDCM0023  KB03 FU-OV-1 C619(1.02)  LDD2745  [1]
 LDCM0024  KB05 OV-90 C619(1.65)  LDD3380  [1]
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal ATPase PEX1 (PEX1) AAA ATPase family O43933
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Progranulin (GRN) Granulin family P28799
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Caspase recruitment domain-containing protein 10 (CARD10) . Q9BWT7
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402