Details of the Target

General Information of Target

Target ID LDTP13329
Target Name Carboxypeptidase A4 (CPA4)
Gene Name CPA4
Gene ID 51200
Synonyms
CPA3; Carboxypeptidase A4; EC 3.4.17.-; Carboxypeptidase A3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLQQSTTITSLEKWCLDESLSGCRRHYSVKKKLKLIRVLGLFMGLVAISTVSFSISAFS
ETDTQSTGEASVVSGPRVAQGYHQRTLLDLNDKILDYTPQPPLSKEGESENSTDHAQGDY
PKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVPSLTVITEKLGISDDVAGATFM
AAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNILFVIGMCALFSREILNLTWWPLFR
DVSFYIVDLIMLIIFFLDNVIMWWESLLLLTAYFCYVVFMKFNVQVEKWVKQMINRNKVV
KVTAPEAQAKPSAARDKDEPTLPAKPRLQRGGSSASLHNSLMRNSIFQLMIHTLDPLAEE
LGSYGKLKYYDTMTEEGRFREKASILHKIAKKKCHVDENERQNGAANHVEKIELPNSTST
DVEMTPSSDASEPVQNGNLSHNIEGAEAQTADEEEDQPLSLAWPSETRKQVTFLIVFPIV
FPLWITLPDVRKPSSRKFFPITFFGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTIL
AAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPLPWLLYTVIHRFQPVAVSS
NGLFCAIVLLFIMLLFVILSIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDRILTCPVS
I
Target Bioclass
Enzyme
Family
Peptidase M14 family
Subcellular location
Secreted
Function Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.
Uniprot ID
Q9UI42
Ensemble ID
ENST00000222482.10
HGNC ID
HGNC:15740
ChEMBL ID
CHEMBL2644

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.S164N .
HT115 SNV: p.A195T; p.R244Q .
KMCH1 SNV: p.S13C .
LS180 SNV: p.S82P .
OVTOKO SNV: p.D385V .
RL952 Deletion: p.R28GfsTer13 .
YSCCC SNV: p.E330K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C250(1.98)  LDD3455  [1]
MPP-AC
 Probe Info  		N.A.  LDD0428  [2]
TER-AC
 Probe Info  		N.A.  LDD0426  [2]
TPP-AC
 Probe Info  		N.A.  LDD0427  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C250(1.53)  LDD2244  [1]
 LDCM0023  KB03 SW1783 C250(2.08)  LDD3038  [1]
 LDCM0024  KB05 SW1783 C250(1.98)  LDD3455  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.