Details of the Target

General Information of Target

Target ID LDTP13216
Target Name Golgi-associated kinase 1A (GASK1A)
Gene Name GASK1A
Gene ID 729085
Synonyms
C3orf41; FAM198A; Golgi-associated kinase 1A; Protein FAM198A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTMAPDVRLEYLEEVASIVLKFKPDKWSKLIGAEENVALFTEFFEKPDVQVLVLTLNAAG
MIIPCLGFPQSLKSKGVYFIKTKSENINKDNYRARLLYGDISPTPVDQLIAVVEEVLSSL
LNQSENMAGWPQVVSEDIVKQVHRLKNEMFVMSGKIKGKTLLPIPEHLGSLDGTLESMER
IPSSLDNLLLHAIETTIIDWSHQIRDVLSKDSAQALLDGLHPLPQVEFEFWDTRLLNLKC
IHEQLNRPKVNKIVEILEKAKSCYWPALQNVYTNVTEGLKEANDIVLYLKPLRILLEEME
QADFTMLPTFIAKVLDTICFIWATSEYYNTPARIIVILQEFCNQIIEMTRTFLSPEEVLK
GLQGEIEEVLSGISLAVNVLKELYQTYDFCCVNMKLFFKDKEPVPWEFPSSLAFSRINSF
FQRIQTIEELYKTAIEFLKLEKIELGGVRGNLLGSLVTRIYDEVFELVKVFADCKYDPLD
PGDSNFDRDYADFEIKIQDLDRRLATIFCQGFDDCSCIKSSAKLLYMCGGLMERPLILAE
VAPRYSVMLELFDAELDNAKILYDAQMAASEEGNIPLIHKNMPPVAGQLKWSLELQERLE
VSMKHLKHVEHPVMSGAEAKLTYQKYDEMMELLRCHREKIYQQWVAGVDQDCHFNLGQPL
ILRDAASNLIHVNFSKALVAVLREVKYLNFQQQKEIPDSAESLFSENETFRKFVGNLELI
VGWYNEIKTIVKAVEFLLIKSELEAIDVKLLSAETTLFWNGEGVFQYIQEVREILHNLQN
RMQKAKQNIEGISQAMKDWSANPLFERKDNKKEALLDLDGRIANLNKRYAAVRDAGVKIQ
AMVAENAELFRADTLSLPWKDYVIYIDDMVLDEFDQFIRKSLSFLMDNMVIDESIAPLFE
IRMELDEDGLTFNPTLEVGSDRGFLALIEGLVNDIYNVARLIPRLAKDRMNYKMDLEDNT
DLIEMREEVSSLVINAMKEAEEYQDSFERYSYLWTDNLQEFMKNFLIYGCAVTAEDLDTW
TDDTIPKTPPTLAQFQEQIDSYEKLYEEVSKCENTKVFHGWLQCDCRPFKQALLSTIRRW
GFMFKRHLSNHVTNSLADLEAFMKVARMGLTKPLKEGDYDGLVEVMGHLMKVKERQAATD
NMFEPLKQTIELLKTYGEEMPEEIHLKLQELPEHWANTKKLAIQVKLTVAPLQANEVSIL
RRKCQQFELKQHEFRERFRREAPFSFSDPNPYKSLNKQQKSISAMEGIMEALSKSGGLFE
VPVPDYKQLKACHREVRLLKELWDMVVVVNTSIEDWKTTKWKDINVEQMDIDCKKFAKDM
RSLDKEMKTWDAFVGLDNTVKNVITSLRAVSELQNPAIRERHWQQLMQATQVKFKMSEET
TLADLLQLNLHSYEDEVRNIVDKAVKESGMEKVLKALDSTWSMMEFQHEPHPRTGTMMLK
SSEVLVETLEDNQVQLQNLMMSKYLAHFLKEVTSWQQKLSTADSVISIWFEVQRTWSHLE
SIFIGSEDIRTQLPGDSQRFDDINQEFKALMEDAVKTPNVVEATSKPGLYNKLEALKKSL
AICEKALAEYLETKRLAFPRFYFVSSADLLDILSNGNDPVEVSRHLSKLFDSLCKLKFRL
DASDKPLKVGLGMYSKEDEYMVFDQECDLSGQVEVWLNRVLDRMCSTLRHEIPEAVVTYE
EKPREQWILDYPAQVALTCTQIWWTTEVGLAFARLEEGYENAIRDYNKKQISQLNVLITL
LMGNLNAGDRMKIMTICTIDVHARDVVAKMIVAKVESSQAFTWQAQLRHRWDEEKRHCFA
NICDAQIQYSYEYLGNTPRLVITPLTDRCYITLTQSLHLIMGGAPAGPAGTGKTETTKDL
GRALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVIAVQVKCVQ
DAIRAKKKAFNFLGEIIGLIPTVGIFITMNPGYAGRAELPENLKALFRPCAMVVPDFELI
CEIMLMAEGFLEARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPS
RAEDQVLMRALRDFNIPKIVTDDLPVFMGLIGDLFPALDVPRKRDLNFEKIIKQSIVELK
LQAEDSFVLKVVQLEELLQVRHSVFIVGNAGSGKSQVLKSLNKTYQNLKRKPVAVDLDPK
AVTCDELFGIINPVTREWKDGLFSTIMRDLANITHDGPKWIILDGDIDPMWIESLNTVMD
DNKVLTLASNERIPLNRTMRLVFEISHLRTATPATVSRAGILYINPADLGWNPVVSSWIE
RRKVQSEKANLMILFDKYLPTCLDKLRFGFKKITPVPEITVIQTILYLLECLLTEKTVPP
DSPRELYELYFVFTCFWAFGGAMFQDQLVDYRVEFSKWWINEFKTIKFPSQGTIFDYYID
PDTKKFLPWTDKVPSFELDPDVPLQASLVHTTETIRIRYFMDLLMEKSWPVMLVGNAGTG
KSVLMGDKLESLNTDNYLVQAVPFNFYTTSAMLQGVLEKPLEKKSGRNYGPPGTKKLVYF
IDDMNMPEVDKYGTVAPHTLIRQHMDHRHWYDRHKLTLKDIHNCQYVACMNPTSGSFTID
SRLQRHFCVFAVSFPGQEALTTIYNTILTQHLAFRSVSMAIQRISSQLVAAALALHQKIT
ATFLPTAIKFHYVFNLRDLSNIFQGLLFSTAEVLKTPLDLVRLWLHETERVYGDKMVDEK
DQETLHRVTMASTKKFFDDLGDELLFAKPNIFCHFAQGIGDPKYVPVTDMAPLNKLLVDV
LDSYNEVNAVMNLVLFEDAVAHICRINRILESPRGNALLVGVGGSGKQSLSRLAAYISGL
DVFQITLKKGYGIPDLKIDLAAQYIKAAVKNVPSVFLMTDSQVAEEQFLVLINDLLASGE
IPGLFMEDEVENIISSMRPQVKSLGMNDTRETCWKFFIEKVRRQLKVILCFSPVGSVLRV
RARKFPAVVNCTAIDWFHEWPEDALVSVSARFLEETEGIPWEVKASISFFMSYVHTTVNE
MSRVYLATERRYNYTTPKTFLEQIKLYQNLLAKKRTELVAKIERLENGLMKLQSTASQVD
DLKAKLAIQEAELKQKNESADQLIQVVGIEAEKVSKEKAIADQEEVKVEVINKNVTEKQK
ACETDLAKAEPALLAAQEALDTLNKNNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPK
DKSWKAAKIMMGKVDTFLDSLKKFDKEHIPEACLKAFKPYQGNPTFDPEFIRSKSTAAAG
LCSWCINIVRFYEVYCDVAPKRQALEEANAELAEAQEKLSRIKNKIAELNANLSNLTSAF
EKATAEKIKCQQEADATNRVILLANRLVGGLASENIRWAESVENFRSQGVTLCGDVLLIS
AFVSYVGYFTKKYRNELMEKFWIPYIHNLKVPIPITNGLDPLSLLTDDADVATWNNQGLP
SDRMSTENATILGNTERWPLIVDAQLQGIKWIKNKYRSELKAIRLGQKSYLDVIEQAISE
GDTLLIENIGETVDPVLDPLLGRNTIKKGKYIKIGDKEVEYHPKFRLILHTKYFNPHYKP
EMQAQCTLINFLVTRDGLEDQLLAAVVAKERPDLEQLKANLTKSQNEFKIVLKELEDSLL
ARLSAASGNFLGDTALVENLETTKHTASEIEEKVVEAKITEVKINEARENYRPAAERASL
LYFILNDLNKINPVYQFSLKAFNVVFEKAIQRTTPANEVKQRVINLTDEITYSVYMYTAR
GLFERDKLIFLAQVTFQVLSMKKELNPVELDFLLRFPFKAGVVSPVDFLQHQGWGGIKAL
SEMDEFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKTALQKLCMVRCLRPDRMTY
AIKNFVEEKMGSKFVEGRSVEFSKSYEESSPSTSIFFILSPGVDPLKDVEALGKKLGFTI
DNGKLHNVSLGQGQEVVAENALDVAAEKGHWVILQNIHLVARWLGTLDKKLEHYSTGSHE
DYRVFISAEPAPSPETHIIPQGILENAIKITNEPPTGMHANLHKALDLFTQDTLEMCTKE
MEFKCMLFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANPKVPWDD
LRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRTEMLEGDVLLAPGFQIPPNLDYKGYHEY
IDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKVKAV
LDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGEL
TITTDVEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLLRIRELEAWTTDFALPTTV
WLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFME
GARWDTQTGVIAEARLKELTPAMPVIFIKAIPVDRMETKNIYECPVYKTRIRGPTYVWTF
NLKTKEKAAKWILAAVALLLQV
Target Bioclass
Other
Family
GASK family
Subcellular location
Secreted
Uniprot ID
Q9UFP1
Ensemble ID
ENST00000273146.6
HGNC ID
HGNC:24485

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C242(0.96)  LDD1508  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C242(0.96)  LDD1508  [1]
 LDCM0259  AC14 HEK-293T C242(0.84)  LDD1512  [1]
 LDCM0270  AC15 HEK-293T C242(0.87)  LDD1513  [1]
 LDCM0277  AC18 HEK-293T C242(0.90)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C242(1.28)  LDD1518  [1]
 LDCM0282  AC22 HEK-293T C242(0.81)  LDD1521  [1]
 LDCM0283  AC23 HEK-293T C242(0.96)  LDD1522  [1]
 LDCM0286  AC26 HEK-293T C242(1.40)  LDD1525  [1]
 LDCM0291  AC30 HEK-293T C242(0.68)  LDD1530  [1]
 LDCM0292  AC31 HEK-293T C242(0.64)  LDD1531  [1]
 LDCM0295  AC34 HEK-293T C242(1.02)  LDD1534  [1]
 LDCM0299  AC38 HEK-293T C242(0.86)  LDD1538  [1]
 LDCM0300  AC39 HEK-293T C242(0.84)  LDD1539  [1]
 LDCM0304  AC42 HEK-293T C242(0.95)  LDD1543  [1]
 LDCM0308  AC46 HEK-293T C242(1.17)  LDD1547  [1]
 LDCM0309  AC47 HEK-293T C242(0.83)  LDD1548  [1]
 LDCM0313  AC50 HEK-293T C242(0.97)  LDD1552  [1]
 LDCM0317  AC54 HEK-293T C242(1.00)  LDD1556  [1]
 LDCM0318  AC55 HEK-293T C242(0.90)  LDD1557  [1]
 LDCM0321  AC58 HEK-293T C242(1.30)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C242(1.05)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C242(0.78)  LDD1565  [1]
 LDCM0327  AC63 HEK-293T C242(0.84)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C242(1.35)  LDD1568  [1]
 LDCM0368  CL10 HEK-293T C242(0.62)  LDD1572  [1]
 LDCM0379  CL11 HEK-293T C242(0.54)  LDD1583  [1]
 LDCM0405  CL18 HEK-293T C242(0.95)  LDD1609  [1]
 LDCM0410  CL22 HEK-293T C242(0.57)  LDD1614  [1]
 LDCM0411  CL23 HEK-293T C242(0.70)  LDD1615  [1]
 LDCM0419  CL30 HEK-293T C242(0.79)  LDD1623  [1]
 LDCM0423  CL34 HEK-293T C242(1.12)  LDD1627  [1]
 LDCM0424  CL35 HEK-293T C242(0.82)  LDD1628  [1]
 LDCM0432  CL42 HEK-293T C242(0.82)  LDD1636  [1]
 LDCM0436  CL46 HEK-293T C242(0.56)  LDD1640  [1]
 LDCM0437  CL47 HEK-293T C242(0.79)  LDD1641  [1]
 LDCM0445  CL54 HEK-293T C242(0.88)  LDD1648  [1]
 LDCM0449  CL58 HEK-293T C242(0.65)  LDD1652  [1]
 LDCM0450  CL59 HEK-293T C242(0.66)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C242(0.98)  LDD1654  [1]
 LDCM0458  CL66 HEK-293T C242(0.87)  LDD1661  [1]
 LDCM0463  CL70 HEK-293T C242(0.77)  LDD1666  [1]
 LDCM0464  CL71 HEK-293T C242(0.78)  LDD1667  [1]
 LDCM0471  CL78 HEK-293T C242(0.77)  LDD1674  [1]
 LDCM0476  CL82 HEK-293T C242(0.86)  LDD1679  [1]
 LDCM0477  CL83 HEK-293T C242(0.53)  LDD1680  [1]
 LDCM0485  CL90 HEK-293T C242(0.84)  LDD1688  [1]
 LDCM0489  CL94 HEK-293T C242(0.72)  LDD1692  [1]
 LDCM0490  CL95 HEK-293T C242(0.58)  LDD1693  [1]
 LDCM0022  KB02 EoL-1 C242(1.01)  LDD2324  [2]
 LDCM0024  KB05 HEL C242(1.85)  LDD3185  [2]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840