Details of the Target

General Information of Target

Target ID LDTP13146
Target Name Beta-ureidopropionase (UPB1)
Gene Name UPB1
Gene ID 51733
Synonyms
BUP1; Beta-ureidopropionase; EC 3.5.1.6; BUP-1; Beta-alanine synthase; N-carbamoyl-beta-alanine amidohydrolase
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRPVRLMKVFVTRRIPAEGRVALARAADCEVEQWDSDEPIPAKELERGVAGAHGLLCLLS
DHVDKRILDAAGANLKVISTMSVGIDHLALDEIKKRGIRVGYTPDVLTDTTAELAVSLLL
TTCRRLPEAIEEVKNGGWTSWKPLWLCGYGLTQSTVGIIGLGRIGQAIARRLKPFGVQRF
LYTGRQPRPEEAAEFQAEFVSTPELAAQSDFIVVACSLTPATEGLCNKDFFQKMKETAVF
INISRGDVVNQDDLYQALASGKIAAAGLDVTSPEPLPTNHPLLTLKNCVILPHIGSATHR
TRNTMSLLAANNLLAGLRGEPMPSELKL
Target Bioclass
Enzyme
Family
Carbon-nitrogen hydrolase superfamily, BUP family
Subcellular location
Cytoplasm
Function
Catalyzes a late step in pyrimidine degradation. Converts N-carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide . Likewise, converts N-carbamoyl-beta-aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide (Probable).
Uniprot ID
Q9UBR1
Ensemble ID
ENST00000326010.10
HGNC ID
HGNC:16297
ChEMBL ID
CHEMBL3430874

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C281(1.18)  LDD2090  [1]
IPM
 Probe Info  		C233(2.62)  LDD1701  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C281(0.52)  LDD2112  [1]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C281(2.10)  LDD2103  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C281(1.33)  LDD2113  [1]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C233(1.35)  LDD1702  [1]
 LDCM0023  KB03 MDA-MB-231 C233(2.62)  LDD1701  [1]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C281(1.82)  LDD2102  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C281(1.18)  LDD2090  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C281(1.73); C284(1.17)  LDD2092  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C281(2.61)  LDD2094  [1]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C281(1.36)  LDD2097  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C281(1.10); C284(0.92)  LDD2098  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C284(0.58)  LDD2108  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C281(0.53)  LDD2114  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C281(1.06)  LDD2115  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C281(0.27)  LDD2116  [1]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C281(0.51)  LDD2118  [1]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C281(0.13)  LDD2124  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C281(0.46)  LDD2148  [1]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C281(0.15); C284(2.83)  LDD2149  [1]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C281(3.55)  LDD2153  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761