Details of the Target

General Information of Target

Target ID LDTP12962
Target Name Disintegrin and metalloproteinase domain-containing protein 22 (ADAM22)
Gene Name ADAM22
Gene ID 53616
Synonyms
MDC2; Disintegrin and metalloproteinase domain-containing protein 22; ADAM 22; Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRHEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGATTTRHTTDHPMQCILTRVD
FDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGD
PNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGG
LSSSQSSYSPSNREAMDPIAELLSQLSGVRRSAGGQLNSSGPSASQLQQLQMQLQLERQH
AQAARQQLETARNATRRTNTSSVTTTITQSTATTNIANTESSQQTLQNSQFLLTRLNDPK
MSETERQSMESERADRSLFVQELLLSTLVREESSSSDEDDRGEMADFGAMGCVDIMPLDV
ALENLNLKESNKGNEPPPPPL
Target Bioclass
Enzyme
Subcellular location
Cell membrane
Function
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
Uniprot ID
Q9P0K1
Ensemble ID
ENST00000265727.11
HGNC ID
HGNC:201

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		7.54  LDD0318  [1]
DBIA
 Probe Info  		C711(1.05)  LDD1492  [2]
IA-alkyne
 Probe Info  		C569(0.00); C349(0.00)  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C711(0.99); C392(1.00)  LDD1512  [2]
 LDCM0281  AC21 HEK-293T C593(0.91)  LDD1520  [2]
 LDCM0282  AC22 HEK-293T C711(0.97); C392(0.80)  LDD1521  [2]
 LDCM0289  AC29 HEK-293T C593(0.88)  LDD1528  [2]
 LDCM0291  AC30 HEK-293T C711(1.05); C392(0.85)  LDD1530  [2]
 LDCM0298  AC37 HEK-293T C593(1.08)  LDD1537  [2]
 LDCM0299  AC38 HEK-293T C711(1.09); C392(0.99)  LDD1538  [2]
 LDCM0307  AC45 HEK-293T C593(0.91)  LDD1546  [2]
 LDCM0308  AC46 HEK-293T C711(1.04); C392(0.80)  LDD1547  [2]
 LDCM0312  AC5 HEK-293T C593(0.99)  LDD1551  [2]
 LDCM0316  AC53 HEK-293T C593(0.88)  LDD1555  [2]
 LDCM0317  AC54 HEK-293T C711(1.11); C392(0.85)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C711(0.93); C392(0.92)  LDD1562  [2]
 LDCM0325  AC61 HEK-293T C593(1.04)  LDD1564  [2]
 LDCM0326  AC62 HEK-293T C711(1.09); C392(0.99)  LDD1565  [2]
 LDCM0248  AKOS034007472 HEK-293T C593(0.97)  LDD1511  [2]
 LDCM0367  CL1 HEK-293T C711(1.00)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C711(1.15); C392(1.14)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C711(1.02)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C392(1.10)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C711(1.00)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C392(0.94)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C711(0.92)  LDD1582  [2]
 LDCM0381  CL111 HEK-293T C392(1.01)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C711(1.06)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C392(0.91)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C711(0.94)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C392(0.89)  LDD1593  [2]
 LDCM0392  CL121 HEK-293T C711(0.96)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C392(1.12)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C711(1.16)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C392(0.99)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C711(1.17)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C392(1.06)  LDD1606  [2]
 LDCM0409  CL21 HEK-293T C593(1.28)  LDD1613  [2]
 LDCM0410  CL22 HEK-293T C711(1.12); C392(0.96)  LDD1614  [2]
 LDCM0413  CL25 HEK-293T C711(1.06)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C392(0.93)  LDD1619  [2]
 LDCM0418  CL3 HEK-293T C392(0.87)  LDD1622  [2]
 LDCM0422  CL33 HEK-293T C593(0.80)  LDD1626  [2]
 LDCM0423  CL34 HEK-293T C711(1.13); C392(0.96)  LDD1627  [2]
 LDCM0426  CL37 HEK-293T C711(1.08)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C392(0.91)  LDD1632  [2]
 LDCM0435  CL45 HEK-293T C593(1.08)  LDD1639  [2]
 LDCM0436  CL46 HEK-293T C711(1.33); C392(1.24)  LDD1640  [2]
 LDCM0439  CL49 HEK-293T C711(1.02)  LDD1643  [2]
 LDCM0448  CL57 HEK-293T C593(1.02)  LDD1651  [2]
 LDCM0449  CL58 HEK-293T C711(1.15); C392(1.03)  LDD1652  [2]
 LDCM0453  CL61 HEK-293T C711(1.11)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C392(0.97)  LDD1658  [2]
 LDCM0461  CL69 HEK-293T C593(1.17)  LDD1664  [2]
 LDCM0463  CL70 HEK-293T C711(1.05); C392(0.96)  LDD1666  [2]
 LDCM0466  CL73 HEK-293T C711(1.01)  LDD1669  [2]
 LDCM0475  CL81 HEK-293T C593(0.81)  LDD1678  [2]
 LDCM0476  CL82 HEK-293T C711(1.03); C392(1.00)  LDD1679  [2]
 LDCM0479  CL85 HEK-293T C711(1.00)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C392(0.98)  LDD1684  [2]
 LDCM0484  CL9 HEK-293T C593(1.13)  LDD1687  [2]
 LDCM0488  CL93 HEK-293T C593(0.99)  LDD1691  [2]
 LDCM0489  CL94 HEK-293T C711(1.30); C392(0.91)  LDD1692  [2]
 LDCM0492  CL97 HEK-293T C711(0.94)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C392(1.05)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C392(0.96)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C392(1.00)  LDD1671  [2]
 LDCM0022  KB02 HEK-293T C711(1.05)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C711(1.09)  LDD1497  [2]
 LDCM0024  KB05 HEK-293T C711(0.95)  LDD1502  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein theta (YWHAQ) 14-3-3 family P27348
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein beta/alpha (YWHAB) 14-3-3 family P31946
Protein scribble homolog (SCRIB) LAP (LRR and PDZ) protein family Q14160

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060