Details of the Target

General Information of Target

Target ID LDTP12845
Target Name Cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3)
Gene Name CELSR3
Gene ID 1951
Synonyms
CDHF11; EGFL1; FMI1; KIAA0812; MEGF2; Cadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; Epidermal growth factor-like protein 1; EGF-like protein 1; Flamingo homolog 1; hFmi1; Multiple epidermal growth factor-like domains protein 2; Multiple EGF-like domains protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRA
PRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALSRRLRARTHLPGCGARARL
CGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR
LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGR
GSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDS
ATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE
RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEA
AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR
VQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG
RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARL
HYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAV
DHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI
TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVT
DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPD
SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS
IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDREN
VAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAK
IRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP
LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNY
TFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITD
DMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV
TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVS
VLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRCRS
REGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC
EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQ
VQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGEKMAVVTVD
DCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGC
MRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFG
GKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDSVLMEATSGGPTSFR
LQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNVKEDSEMKHLVTMTLDY
GMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQGVRMGGTPTNVATLNMNN
ALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDKGYLGINCVDACHLNPCENMG
ACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWWGNPVCGPCHCAVSKGFDPDCNK
TNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCDMATGQCACKPGVIGRQCNRCDNPF
AEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPAAVPCPKGSVGNAVRHCSGEKGWLPPE
LFNCTTISFVDLRAMNEKLSRNETQVDGARALQLVRALRSATQHTGTLFGNDVRTAYQLL
GHVLQHESWQQGFDLAATQDADFHEDVIHSGSALLAPATRAAWEQIQRSEGGTAQLLRRL
EGYFSNVARNVRRTYLRPFVIVTANMILAVDIFDKFNFTGARVPRFDTIHEEFPRELESS
VSFPADFFRPPEEKEGPLLRPAGRRTTPQTTRPGPGTEREAPISRRRRHPDDAGQFAVAL
VIIYRTLGQLLPERYDPDRRSLRLPHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFAL
LEVEERTKPVCVFWNHSLAVGGTGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRR
ENGEVLPLKIVTYAAVSLSLAALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVI
GINQTENPFLCTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWG
IPAIVTGLAVGLDPQGYGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQR
KHHYYGKKGIVSLLRTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLF
HCVLNQEVRKHLKGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTA
SLDSIVRDEGIQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSY
ASSHSSDSEDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKP
RLKVETKVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLT
LTEQTLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVR
TGSAQADGSDSEKP
Target Bioclass
GPCR
Family
G-protein coupled receptor 2 family, LN-TM7 subfamily
Subcellular location
Cell membrane
Function Receptor that may have an important role in cell/cell signaling during nervous system formation.
Uniprot ID
Q9NYQ7
Ensemble ID
ENST00000164024.5
HGNC ID
HGNC:3230

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.F1427L .
A3KAW SNV: p.R121H .
AGS SNV: p.F1072C .
CAL72 SNV: p.A2119S .
CCK81 SNV: p.G1975C .
COLO792 SNV: p.P2050S .
HCT116 Deletion: p.G1903AfsTer36;p.H2004MfsTer114
SNV: p.D1161E		 .
HCT15 Deletion: p.F433LfsTer101
SNV: p.P236L;p.V1805L;p.D3183G		 .
HS936T SNV: p.L1837F .
HSC3 SNV: p.R9Q; p.R89Q .
IGROV1 SNV: p.A985V .
JURKAT Deletion: p.G809VfsTer5;p.A2340PfsTer45
SNV: p.C2010Y		 .
KELLY SNV: p.V2150A .
KMS27 SNV: p.V2622A .
LN229 SNV: p.A1949V .
LNCaP clone FGC SNV: p.Q960Ter; p.D1093N .
LOXIMVI SNV: p.G808E .
LS180 Deletion: p.R198EfsTer110 .
LUDLU1 SNV: p.L1206V .
MFE296 SNV: p.R2283L .
MFE319 SNV: p.Q2245Ter; p.R3117Q; p.H3311N .
MOLT4 SNV: p.L3121M .
NCIH1155 SNV: p.T2219I .
OV90 SNV: p.A257T .
OVK18 Deletion: p.N465TfsTer69 .
PF382 SNV: p.E124K; p.V2295A .
REH SNV: p.S2464N .
RKN SNV: p.P2398Q .
RKO Deletion: p.E615VfsTer31 .
RL952 SNV: p.A1332V .
SKES1 SNV: p.I893T .
SKMEL2 SNV: p.S98N .
SNGM SNV: p.D2072G .
SNU1 SNV: p.I1265V; p.P2181T .
SNU308 SNV: p.G1190D .
SNU5 SNV: p.R2565P .
TOV21G SNV: p.R619C; p.W2139L .
U937 SNV: p.P2926L; p.L3246I .
UMUC3 SNV: p.F1543L .
YSCCC SNV: p.G1488S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K548(1.02); K2131(1.56)  LDD3494  [1]
DBIA
 Probe Info  		C1384(1.71)  LDD3468  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C1500(1.15); C1502(1.15)  LDD1509  [3]
 LDCM0278  AC19 HEK-293T C1500(0.91); C1502(0.91)  LDD1517  [3]
 LDCM0281  AC21 HEK-293T C1384(1.01)  LDD1520  [3]
 LDCM0284  AC24 HEK-293T C1384(0.98)  LDD1523  [3]
 LDCM0287  AC27 HEK-293T C1500(1.16); C1502(1.16)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C1384(1.03)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C1500(0.92); C1502(0.92)  LDD1529  [3]
 LDCM0293  AC32 HEK-293T C1384(0.92)  LDD1532  [3]
 LDCM0296  AC35 HEK-293T C1500(1.01); C1502(1.01)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C1384(0.94)  LDD1537  [3]
 LDCM0302  AC40 HEK-293T C1384(1.01)  LDD1541  [3]
 LDCM0305  AC43 HEK-293T C1500(1.08); C1502(1.08)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C1384(1.05)  LDD1546  [3]
 LDCM0310  AC48 HEK-293T C1384(0.95)  LDD1549  [3]
 LDCM0312  AC5 HEK-293T C1384(0.97)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C1500(1.00); C1502(1.00)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C1384(0.94)  LDD1555  [3]
 LDCM0319  AC56 HEK-293T C1384(1.01)  LDD1558  [3]
 LDCM0322  AC59 HEK-293T C1500(1.14); C1502(1.14)  LDD1561  [3]
 LDCM0325  AC61 HEK-293T C1384(0.88)  LDD1564  [3]
 LDCM0328  AC64 HEK-293T C1384(0.96)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C1384(0.99)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C1384(1.03)  LDD1511  [3]
 LDCM0275  AKOS034007705 HEK-293T C1384(1.01)  LDD1514  [3]
 LDCM0390  CL12 HEK-293T C1384(1.34)  LDD1594  [3]
 LDCM0406  CL19 HEK-293T C1500(0.98); C1502(0.98)  LDD1610  [3]
 LDCM0409  CL21 HEK-293T C1384(1.54)  LDD1613  [3]
 LDCM0412  CL24 HEK-293T C1384(1.45)  LDD1616  [3]
 LDCM0420  CL31 HEK-293T C1500(1.05); C1502(1.05)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C1384(1.36)  LDD1626  [3]
 LDCM0425  CL36 HEK-293T C1384(1.49)  LDD1629  [3]
 LDCM0433  CL43 HEK-293T C1500(0.91); C1502(0.91)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C1384(1.36)  LDD1639  [3]
 LDCM0438  CL48 HEK-293T C1384(1.36)  LDD1642  [3]
 LDCM0446  CL55 HEK-293T C1500(0.93); C1502(0.93)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C1384(1.47)  LDD1651  [3]
 LDCM0452  CL60 HEK-293T C1384(1.45)  LDD1655  [3]
 LDCM0459  CL67 HEK-293T C1500(1.00); C1502(1.00)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C1384(1.26)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C1500(0.98); C1502(0.98)  LDD1665  [3]
 LDCM0465  CL72 HEK-293T C1384(1.27)  LDD1668  [3]
 LDCM0472  CL79 HEK-293T C1500(0.94); C1502(0.94)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C1384(1.25)  LDD1678  [3]
 LDCM0478  CL84 HEK-293T C1384(1.31)  LDD1681  [3]
 LDCM0484  CL9 HEK-293T C1384(1.41)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C1500(1.06); C1502(1.06)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C1384(1.18)  LDD1691  [3]
 LDCM0491  CL96 HEK-293T C1384(1.10)  LDD1694  [3]
 LDCM0022  KB02 CAL-33 C1384(2.18)  LDD2287  [2]
 LDCM0023  KB03 CAL-33 C1384(3.23)  LDD2704  [2]
 LDCM0024  KB05 TE-11 C1384(1.71)  LDD3468  [2]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402