Details of the Target

General Information of Target

Target ID LDTP12844
Target Name Cadherin EGF LAG seven-pass G-type receptor 1 (CELSR1)
Gene Name CELSR1
Gene ID 9620
Synonyms
CDHF9; FMI2; Cadherin EGF LAG seven-pass G-type receptor 1; Cadherin family member 9; Flamingo homolog 2; hFmi2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRYLRDVSEVDT
RTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGICYITSTFASCSLEDIVIAA
PEGLRWFQLYVHPDLQLNKQLIQRVESLGFKALVITLDTPVCGNRRHDIRNQLRRNLTLT
DLQSPKKGNAIPYFQMTPISTSLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQG
IIVSNHGGRQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLG
RPILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL
Target Bioclass
GPCR
Family
G-protein coupled receptor 2 family, LN-TM7 subfamily
Subcellular location
Cell membrane
Function Receptor that may have an important role in cell/cell signaling during nervous system formation.
Uniprot ID
Q9NYQ6
Ensemble ID
ENST00000262738.9
HGNC ID
HGNC:1850

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K324(0.87); K1830(0.93); K2118(2.31); K316(3.82)  LDD3494  [1]
DBIA
 Probe Info  		C1840(3.07)  LDD3373  [2]
IPIAA_H
 Probe Info  		C1673(0.00); C1675(0.00)  LDD0030  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
PF-06672131
 Probe Info  		N.A.  LDD0152  [5]
m-APA
 Probe Info  		N.A.  LDD0404  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C2431(1.37)  LDD1508  [7]
 LDCM0259  AC14 HEK-293T C2976(1.08); C1620(0.87)  LDD1512  [7]
 LDCM0277  AC18 HEK-293T C2431(1.12)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C2431(1.27)  LDD1518  [7]
 LDCM0281  AC21 HEK-293T C2976(1.30)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C2976(0.96); C1620(1.07)  LDD1521  [7]
 LDCM0286  AC26 HEK-293T C2431(1.62)  LDD1525  [7]
 LDCM0289  AC29 HEK-293T C2976(1.12)  LDD1528  [7]
 LDCM0291  AC30 HEK-293T C2976(1.30); C1620(0.85)  LDD1530  [7]
 LDCM0295  AC34 HEK-293T C2431(1.39)  LDD1534  [7]
 LDCM0298  AC37 HEK-293T C2976(1.27)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C2976(1.17); C1620(0.88)  LDD1538  [7]
 LDCM0304  AC42 HEK-293T C2431(1.45)  LDD1543  [7]
 LDCM0307  AC45 HEK-293T C2976(1.18)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C2976(1.12); C1620(0.91)  LDD1547  [7]
 LDCM0312  AC5 HEK-293T C2976(0.96)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C2431(0.80)  LDD1552  [7]
 LDCM0316  AC53 HEK-293T C2976(1.39)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C2976(1.15); C1620(0.90)  LDD1556  [7]
 LDCM0321  AC58 HEK-293T C2431(0.95)  LDD1560  [7]
 LDCM0323  AC6 HEK-293T C2976(1.20); C1620(1.16)  LDD1562  [7]
 LDCM0325  AC61 HEK-293T C2976(1.25)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C2976(1.20); C1620(1.25)  LDD1565  [7]
 LDCM0248  AKOS034007472 HEK-293T C2976(1.25)  LDD1511  [7]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [6]
 LDCM0020  ARS-1620 HCC44 C48(1.18); C56(1.18)  LDD2171  [8]
 LDCM0368  CL10 HEK-293T C2976(1.26); C1620(1.26)  LDD1572  [7]
 LDCM0372  CL103 HEK-293T C2976(1.43)  LDD1576  [7]
 LDCM0376  CL107 HEK-293T C2976(1.09)  LDD1580  [7]
 LDCM0381  CL111 HEK-293T C2976(1.11)  LDD1585  [7]
 LDCM0385  CL115 HEK-293T C2976(1.18)  LDD1589  [7]
 LDCM0389  CL119 HEK-293T C2976(1.13)  LDD1593  [7]
 LDCM0394  CL123 HEK-293T C2976(1.03)  LDD1598  [7]
 LDCM0398  CL127 HEK-293T C2976(1.01)  LDD1602  [7]
 LDCM0402  CL15 HEK-293T C2976(1.20)  LDD1606  [7]
 LDCM0405  CL18 HEK-293T C2431(1.55)  LDD1609  [7]
 LDCM0409  CL21 HEK-293T C2976(1.49)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C2976(1.16); C1620(0.97)  LDD1614  [7]
 LDCM0415  CL27 HEK-293T C2976(1.27)  LDD1619  [7]
 LDCM0418  CL3 HEK-293T C2976(1.30)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C2431(1.13)  LDD1623  [7]
 LDCM0422  CL33 HEK-293T C2976(1.22)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C2976(1.07); C1620(0.78)  LDD1627  [7]
 LDCM0428  CL39 HEK-293T C2976(1.27)  LDD1632  [7]
 LDCM0432  CL42 HEK-293T C2431(0.97)  LDD1636  [7]
 LDCM0435  CL45 HEK-293T C2976(1.27)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C2976(1.03); C1620(0.81)  LDD1640  [7]
 LDCM0445  CL54 HEK-293T C2431(1.23)  LDD1648  [7]
 LDCM0448  CL57 HEK-293T C2976(1.36)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C2976(1.26); C1620(0.99)  LDD1652  [7]
 LDCM0451  CL6 HEK-293T C2431(1.13)  LDD1654  [7]
 LDCM0455  CL63 HEK-293T C2976(1.13)  LDD1658  [7]
 LDCM0458  CL66 HEK-293T C2431(1.35)  LDD1661  [7]
 LDCM0461  CL69 HEK-293T C2976(1.27)  LDD1664  [7]
 LDCM0463  CL70 HEK-293T C2976(1.41); C1620(1.02)  LDD1666  [7]
 LDCM0471  CL78 HEK-293T C2431(1.15)  LDD1674  [7]
 LDCM0475  CL81 HEK-293T C2976(1.23)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C2976(1.21); C1620(1.14)  LDD1679  [7]
 LDCM0481  CL87 HEK-293T C2976(1.01)  LDD1684  [7]
 LDCM0484  CL9 HEK-293T C2976(1.22)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C2431(1.55)  LDD1688  [7]
 LDCM0488  CL93 HEK-293T C2976(1.15)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C2976(1.15); C1620(0.96)  LDD1692  [7]
 LDCM0494  CL99 HEK-293T C2976(1.21)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C2976(1.10)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C2976(1.43)  LDD1671  [7]
 LDCM0022  KB02 A-549 C1840(2.07)  LDD2260  [2]
 LDCM0023  KB03 A-549 C1840(2.06)  LDD2677  [2]
 LDCM0024  KB05 OCUG-1 C1840(3.07)  LDD3373  [2]
 LDCM0021  THZ1 HCT 116 C48(1.18); C56(1.18)  LDD2173  [8]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
6 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.