Details of the Target

General Information of Target

Target ID LDTP12774
Target Name Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1)
Gene Name GFOD1
Gene ID 54438
Synonyms
C6orf114; Glucose-fructose oxidoreductase domain-containing protein 1; EC 1.-.-.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRP
ALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYY
FSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIH
ILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSS
YMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ
Target Bioclass
Enzyme
Family
Gfo/Idh/MocA family
Subcellular location
Secreted
Uniprot ID
Q9NXC2
Ensemble ID
ENST00000379284.1
HGNC ID
HGNC:21096

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.G153D .
HCT15 SNV: p.D322N .
KARPAS422 SNV: p.P284L .
LNCaP clone FGC SNV: p.A96T .
PANC1 SNV: p.K22E .
REH SNV: p.V140M .
SNGM SNV: p.P72S .
SW1116 Deletion: p.Y139_V140del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C68(0.97); C146(1.00)  LDD1514  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C68(0.99); C146(0.84)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C68(0.91); C146(0.98)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C68(0.88); C146(0.89)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C68(1.10); C146(1.00)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C68(1.13); C146(0.90)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C68(0.94); C146(0.92)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C68(0.91); C146(0.92)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C68(0.97); C146(1.00)  LDD1514  [1]
 LDCM0367  CL1 HEK-293T C68(1.12)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C68(1.10)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C146(1.33)  LDD1575  [1]
 LDCM0374  CL105 HEK-293T C68(1.17)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C146(1.06)  LDD1579  [1]
 LDCM0378  CL109 HEK-293T C68(0.78)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C146(0.97)  LDD1584  [1]
 LDCM0383  CL113 HEK-293T C68(1.14)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C146(1.16)  LDD1588  [1]
 LDCM0387  CL117 HEK-293T C68(1.34)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C146(1.54)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C68(1.18); C146(0.91)  LDD1594  [1]
 LDCM0392  CL121 HEK-293T C68(1.04)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C146(1.05)  LDD1597  [1]
 LDCM0396  CL125 HEK-293T C68(0.99)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C146(1.15)  LDD1601  [1]
 LDCM0400  CL13 HEK-293T C68(1.20)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C146(1.30)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C146(0.99)  LDD1611  [1]
 LDCM0412  CL24 HEK-293T C68(0.99); C146(0.96)  LDD1616  [1]
 LDCM0413  CL25 HEK-293T C68(0.94)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C146(1.22)  LDD1618  [1]
 LDCM0425  CL36 HEK-293T C68(0.88); C146(0.95)  LDD1629  [1]
 LDCM0426  CL37 HEK-293T C68(1.04)  LDD1630  [1]
 LDCM0438  CL48 HEK-293T C68(1.13); C146(0.85)  LDD1642  [1]
 LDCM0439  CL49 HEK-293T C68(1.25)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C146(1.29)  LDD1645  [1]
 LDCM0452  CL60 HEK-293T C68(1.06); C146(1.07)  LDD1655  [1]
 LDCM0453  CL61 HEK-293T C68(1.25)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C146(1.33)  LDD1657  [1]
 LDCM0465  CL72 HEK-293T C68(1.07); C146(0.90)  LDD1668  [1]
 LDCM0466  CL73 HEK-293T C68(1.00)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C146(1.12)  LDD1670  [1]
 LDCM0478  CL84 HEK-293T C68(0.89); C146(1.15)  LDD1681  [1]
 LDCM0479  CL85 HEK-293T C68(1.28)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C146(1.28)  LDD1683  [1]
 LDCM0491  CL96 HEK-293T C68(0.87); C146(1.12)  LDD1694  [1]
 LDCM0492  CL97 HEK-293T C68(0.45)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C146(1.23)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C146(1.10)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402