Details of the Target
General Information of Target
Target ID | LDTP12749 | |||||
---|---|---|---|---|---|---|
Target Name | AFG2-interacting ribosome maturation factor (AIRIM) | |||||
Gene Name | AIRIM | |||||
Gene ID | 54955 | |||||
Synonyms |
C1orf109; AFG2-interacting ribosome maturation factor; Ribosome biogenesis protein C1orf109 |
|||||
3D Structure | ||||||
Sequence |
MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT
THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFK YAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGAL IEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFL EEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVP TCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDL RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLS GVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHSTVT DLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKE NLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILC EQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRH PECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKC FLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQ TLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLW LWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKI DDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAERPSSHDFMI |
|||||
Target Bioclass |
Other
|
|||||
Subcellular location |
Nucleus
|
|||||
Function |
Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Acts together with AFG2A, AFG2B and CINP.
|
|||||
Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
DBIA Probe Info |
![]() |
C17(1.34) | LDD0533 | [1] | |
4-Iodoacetamidophenylacetylene Probe Info |
![]() |
C35(0.00); C17(0.00) | LDD0038 | [2] | |
IA-alkyne Probe Info |
![]() |
N.A. | LDD0162 | [3] | |
Lodoacetamide azide Probe Info |
![]() |
C35(0.00); C17(0.00) | LDD0037 | [2] | |
NAIA_5 Probe Info |
![]() |
N.A. | LDD2223 | [4] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
---|---|---|---|---|---|
LDCM0216 | AC100 | HCT 116 | C17(1.34) | LDD0533 | [1] |
LDCM0217 | AC101 | HCT 116 | C17(1.13) | LDD0534 | [1] |
LDCM0218 | AC102 | HCT 116 | C17(1.03) | LDD0535 | [1] |
LDCM0219 | AC103 | HCT 116 | C17(1.19) | LDD0536 | [1] |
LDCM0220 | AC104 | HCT 116 | C17(0.98) | LDD0537 | [1] |
LDCM0221 | AC105 | HCT 116 | C17(1.21) | LDD0538 | [1] |
LDCM0222 | AC106 | HCT 116 | C17(1.84) | LDD0539 | [1] |
LDCM0223 | AC107 | HCT 116 | C17(1.63) | LDD0540 | [1] |
LDCM0224 | AC108 | HCT 116 | C17(1.08) | LDD0541 | [1] |
LDCM0225 | AC109 | HCT 116 | C17(1.12) | LDD0542 | [1] |
LDCM0227 | AC110 | HCT 116 | C17(1.62) | LDD0544 | [1] |
LDCM0228 | AC111 | HCT 116 | C17(1.36) | LDD0545 | [1] |
LDCM0229 | AC112 | HCT 116 | C17(1.12) | LDD0546 | [1] |
LDCM0276 | AC17 | HCT 116 | C17(0.85) | LDD0593 | [1] |
LDCM0277 | AC18 | HCT 116 | C17(0.53) | LDD0594 | [1] |
LDCM0278 | AC19 | HCT 116 | C17(0.95) | LDD0595 | [1] |
LDCM0280 | AC20 | HCT 116 | C17(0.71) | LDD0597 | [1] |
LDCM0281 | AC21 | HCT 116 | C17(0.58) | LDD0598 | [1] |
LDCM0282 | AC22 | HCT 116 | C17(0.69) | LDD0599 | [1] |
LDCM0283 | AC23 | HCT 116 | C17(0.73) | LDD0600 | [1] |
LDCM0284 | AC24 | HCT 116 | C17(0.84) | LDD0601 | [1] |
LDCM0308 | AC46 | HCT 116 | C17(0.85) | LDD0625 | [1] |
LDCM0309 | AC47 | HCT 116 | C17(2.26) | LDD0626 | [1] |
LDCM0310 | AC48 | HCT 116 | C17(1.07) | LDD0627 | [1] |
LDCM0311 | AC49 | HCT 116 | C17(0.85) | LDD0628 | [1] |
LDCM0313 | AC50 | HCT 116 | C17(1.09) | LDD0630 | [1] |
LDCM0314 | AC51 | HCT 116 | C17(1.12) | LDD0631 | [1] |
LDCM0315 | AC52 | HCT 116 | C17(1.41) | LDD0632 | [1] |
LDCM0316 | AC53 | HCT 116 | C17(1.23) | LDD0633 | [1] |
LDCM0317 | AC54 | HCT 116 | C17(1.11) | LDD0634 | [1] |
LDCM0318 | AC55 | HCT 116 | C17(1.10) | LDD0635 | [1] |
LDCM0319 | AC56 | HCT 116 | C17(1.17) | LDD0636 | [1] |
LDCM0320 | AC57 | HCT 116 | C17(1.07) | LDD0637 | [1] |
LDCM0321 | AC58 | HCT 116 | C17(0.71) | LDD0638 | [1] |
LDCM0322 | AC59 | HCT 116 | C17(0.75) | LDD0639 | [1] |
LDCM0324 | AC60 | HCT 116 | C17(0.59) | LDD0641 | [1] |
LDCM0325 | AC61 | HCT 116 | C17(0.80) | LDD0642 | [1] |
LDCM0326 | AC62 | HCT 116 | C17(0.87) | LDD0643 | [1] |
LDCM0327 | AC63 | HCT 116 | C17(0.60) | LDD0644 | [1] |
LDCM0328 | AC64 | HCT 116 | C17(0.80) | LDD0645 | [1] |
LDCM0329 | AC65 | HCT 116 | C17(0.82) | LDD0646 | [1] |
LDCM0330 | AC66 | HCT 116 | C17(0.61) | LDD0647 | [1] |
LDCM0331 | AC67 | HCT 116 | C17(0.68) | LDD0648 | [1] |
LDCM0332 | AC68 | HCT 116 | C17(1.49) | LDD0649 | [1] |
LDCM0333 | AC69 | HCT 116 | C17(0.98) | LDD0650 | [1] |
LDCM0335 | AC70 | HCT 116 | C17(1.28) | LDD0652 | [1] |
LDCM0336 | AC71 | HCT 116 | C17(1.65) | LDD0653 | [1] |
LDCM0337 | AC72 | HCT 116 | C17(1.25) | LDD0654 | [1] |
LDCM0338 | AC73 | HCT 116 | C17(1.60) | LDD0655 | [1] |
LDCM0339 | AC74 | HCT 116 | C17(1.08) | LDD0656 | [1] |
LDCM0340 | AC75 | HCT 116 | C17(1.28) | LDD0657 | [1] |
LDCM0341 | AC76 | HCT 116 | C17(1.19) | LDD0658 | [1] |
LDCM0342 | AC77 | HCT 116 | C17(1.46) | LDD0659 | [1] |
LDCM0343 | AC78 | HCT 116 | C17(1.39) | LDD0660 | [1] |
LDCM0344 | AC79 | HCT 116 | C17(1.05) | LDD0661 | [1] |
LDCM0346 | AC80 | HCT 116 | C17(1.41) | LDD0663 | [1] |
LDCM0347 | AC81 | HCT 116 | C17(1.01) | LDD0664 | [1] |
LDCM0348 | AC82 | HCT 116 | C17(1.01) | LDD0665 | [1] |
LDCM0365 | AC98 | HCT 116 | C17(1.32) | LDD0682 | [1] |
LDCM0366 | AC99 | HCT 116 | C17(1.19) | LDD0683 | [1] |
LDCM0367 | CL1 | HCT 116 | C17(0.88) | LDD0684 | [1] |
LDCM0368 | CL10 | HCT 116 | C17(0.97) | LDD0685 | [1] |
LDCM0374 | CL105 | HCT 116 | C17(0.86) | LDD0691 | [1] |
LDCM0375 | CL106 | HCT 116 | C17(0.51) | LDD0692 | [1] |
LDCM0376 | CL107 | HCT 116 | C17(0.80) | LDD0693 | [1] |
LDCM0377 | CL108 | HCT 116 | C17(0.69) | LDD0694 | [1] |
LDCM0378 | CL109 | HCT 116 | C17(1.10) | LDD0695 | [1] |
LDCM0379 | CL11 | HCT 116 | C17(0.82) | LDD0696 | [1] |
LDCM0380 | CL110 | HCT 116 | C17(0.74) | LDD0697 | [1] |
LDCM0381 | CL111 | HCT 116 | C17(0.73) | LDD0698 | [1] |
LDCM0390 | CL12 | HCT 116 | C17(1.00) | LDD0707 | [1] |
LDCM0392 | CL121 | HCT 116 | C17(1.29) | LDD0709 | [1] |
LDCM0393 | CL122 | HCT 116 | C17(0.86) | LDD0710 | [1] |
LDCM0394 | CL123 | HCT 116 | C17(1.05) | LDD0711 | [1] |
LDCM0395 | CL124 | HCT 116 | C17(1.10) | LDD0712 | [1] |
LDCM0396 | CL125 | HCT 116 | C17(0.92) | LDD0713 | [1] |
LDCM0397 | CL126 | HCT 116 | C17(0.82) | LDD0714 | [1] |
LDCM0398 | CL127 | HCT 116 | C17(0.80) | LDD0715 | [1] |
LDCM0399 | CL128 | HCT 116 | C17(1.09) | LDD0716 | [1] |
LDCM0400 | CL13 | HCT 116 | C17(1.17) | LDD0717 | [1] |
LDCM0401 | CL14 | HCT 116 | C17(1.06) | LDD0718 | [1] |
LDCM0402 | CL15 | HCT 116 | C17(0.91) | LDD0719 | [1] |
LDCM0403 | CL16 | HCT 116 | C17(0.78) | LDD0720 | [1] |
LDCM0404 | CL17 | HCT 116 | C17(0.66) | LDD0721 | [1] |
LDCM0405 | CL18 | HCT 116 | C17(0.53) | LDD0722 | [1] |
LDCM0406 | CL19 | HCT 116 | C17(0.70) | LDD0723 | [1] |
LDCM0407 | CL2 | HCT 116 | C17(0.90) | LDD0724 | [1] |
LDCM0408 | CL20 | HCT 116 | C17(0.82) | LDD0725 | [1] |
LDCM0409 | CL21 | HCT 116 | C17(0.64) | LDD0726 | [1] |
LDCM0410 | CL22 | HCT 116 | C17(0.76) | LDD0727 | [1] |
LDCM0411 | CL23 | HCT 116 | C17(0.89) | LDD0728 | [1] |
LDCM0412 | CL24 | HCT 116 | C17(0.70) | LDD0729 | [1] |
LDCM0413 | CL25 | HCT 116 | C17(0.75) | LDD0730 | [1] |
LDCM0414 | CL26 | HCT 116 | C17(0.64) | LDD0731 | [1] |
LDCM0415 | CL27 | HCT 116 | C17(0.90) | LDD0732 | [1] |
LDCM0416 | CL28 | HCT 116 | C17(0.68) | LDD0733 | [1] |
LDCM0417 | CL29 | HCT 116 | C17(0.71) | LDD0734 | [1] |
LDCM0418 | CL3 | HCT 116 | C17(0.93) | LDD0735 | [1] |
LDCM0419 | CL30 | HCT 116 | C17(0.79) | LDD0736 | [1] |
LDCM0429 | CL4 | HCT 116 | C17(0.88) | LDD0746 | [1] |
LDCM0440 | CL5 | HCT 116 | C17(1.08) | LDD0757 | [1] |
LDCM0451 | CL6 | HCT 116 | C17(1.11) | LDD0768 | [1] |
LDCM0453 | CL61 | HCT 116 | C17(1.06) | LDD0770 | [1] |
LDCM0454 | CL62 | HCT 116 | C17(0.98) | LDD0771 | [1] |
LDCM0455 | CL63 | HCT 116 | C17(1.02) | LDD0772 | [1] |
LDCM0456 | CL64 | HCT 116 | C17(1.07) | LDD0773 | [1] |
LDCM0457 | CL65 | HCT 116 | C17(0.80) | LDD0774 | [1] |
LDCM0458 | CL66 | HCT 116 | C17(0.93) | LDD0775 | [1] |
LDCM0459 | CL67 | HCT 116 | C17(1.14) | LDD0776 | [1] |
LDCM0460 | CL68 | HCT 116 | C17(0.92) | LDD0777 | [1] |
LDCM0461 | CL69 | HCT 116 | C17(0.88) | LDD0778 | [1] |
LDCM0462 | CL7 | HCT 116 | C17(1.18) | LDD0779 | [1] |
LDCM0463 | CL70 | HCT 116 | C17(0.86) | LDD0780 | [1] |
LDCM0464 | CL71 | HCT 116 | C17(1.10) | LDD0781 | [1] |
LDCM0465 | CL72 | HCT 116 | C17(1.06) | LDD0782 | [1] |
LDCM0466 | CL73 | HCT 116 | C17(0.84) | LDD0783 | [1] |
LDCM0467 | CL74 | HCT 116 | C17(0.87) | LDD0784 | [1] |
LDCM0473 | CL8 | HCT 116 | C17(0.87) | LDD0790 | [1] |
LDCM0484 | CL9 | HCT 116 | C17(0.90) | LDD0801 | [1] |
LDCM0468 | Fragment33 | HCT 116 | C17(1.20) | LDD0785 | [1] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transporter and channel
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Nucleoporin p54 (NUP54) | NUP54 family | Q7Z3B4 | |||
AP-4 complex accessory subunit Tepsin (TEPSIN) | . | Q96N21 | |||
Syntenin-1 (SDCBP) | . | O00560 |
Transcription factor
Other
References