Details of the Target

General Information of Target

Target ID LDTP12601
Target Name Leucine-rich repeat-containing protein 4B (LRRC4B)
Gene Name LRRC4B
Gene ID 94030
Synonyms
LRIG4; Leucine-rich repeat-containing protein 4B; Netrin-G3 ligand; NGL-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNR
VTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTE
GGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLL
PSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPP
NHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQ
LQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRK
AFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIAMHLLGLNWQLQPADGHTFNNGIRT
GLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLK
FNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVF
VQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGA
DCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSA
GYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDT
GLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTC
KDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGC
NVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVK
SFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYT
ITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCD
LSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRTAGYK
SLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLS
DAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGE
NQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIR
RIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTK
DLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKV
DQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRI
TENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINR
LRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIA
DLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYS
TDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLM
TYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNR
DDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTIT
PTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKI
YDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGR
IVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSI
GYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTF
GYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRI
ASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRI
KEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRP
TWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEY
NSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSN
SEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYD
SNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMF
KSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENG
QLITGVQQTTERHNQAFMALEGQVITKKLHASIREKAGHWFATTTPIIGKGIMFAIKEGR
VTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLVTLGTTIGR
KVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQAR
QRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSS
SNIQFLRQNEMGKR
Target Bioclass
Immunoglobulin
Subcellular location
Membrane
Function
Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner.
Uniprot ID
Q9NT99
Ensemble ID
ENST00000389201.7
HGNC ID
HGNC:25042

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C683(1.03)  LDD1514  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C683(0.85)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C683(0.91)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C683(0.87)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C683(1.33)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C683(1.22)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C683(0.85)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C683(1.06)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C683(1.03)  LDD1514  [1]
 LDCM0371  CL102 HEK-293T C683(1.12)  LDD1575  [1]
 LDCM0375  CL106 HEK-293T C683(1.02)  LDD1579  [1]
 LDCM0380  CL110 HEK-293T C683(1.09)  LDD1584  [1]
 LDCM0384  CL114 HEK-293T C683(1.22)  LDD1588  [1]
 LDCM0388  CL118 HEK-293T C683(1.31)  LDD1592  [1]
 LDCM0390  CL12 HEK-293T C683(1.03)  LDD1594  [1]
 LDCM0393  CL122 HEK-293T C683(0.99)  LDD1597  [1]
 LDCM0397  CL126 HEK-293T C683(0.97)  LDD1601  [1]
 LDCM0401  CL14 HEK-293T C683(1.07)  LDD1605  [1]
 LDCM0407  CL2 HEK-293T C683(0.97)  LDD1611  [1]
 LDCM0412  CL24 HEK-293T C683(0.97)  LDD1616  [1]
 LDCM0414  CL26 HEK-293T C683(1.07)  LDD1618  [1]
 LDCM0425  CL36 HEK-293T C683(0.88)  LDD1629  [1]
 LDCM0438  CL48 HEK-293T C683(1.11)  LDD1642  [1]
 LDCM0441  CL50 HEK-293T C683(1.18)  LDD1645  [1]
 LDCM0452  CL60 HEK-293T C683(1.21)  LDD1655  [1]
 LDCM0454  CL62 HEK-293T C683(1.21)  LDD1657  [1]
 LDCM0465  CL72 HEK-293T C683(1.31)  LDD1668  [1]
 LDCM0467  CL74 HEK-293T C683(1.26)  LDD1670  [1]
 LDCM0478  CL84 HEK-293T C683(0.91)  LDD1681  [1]
 LDCM0480  CL86 HEK-293T C683(0.86)  LDD1683  [1]
 LDCM0491  CL96 HEK-293T C683(1.13)  LDD1694  [1]
 LDCM0493  CL98 HEK-293T C683(1.34)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C683(1.09)  LDD1631  [1]
 LDCM0022  KB02 MGG123 C217(3.24)  LDD2469  [3]
 LDCM0023  KB03 MGG123 C217(4.57)  LDD2886  [3]
 LDCM0024  KB05 MGG123 C217(3.77)  LDD3303  [3]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840