Details of the Target

General Information of Target

Target ID LDTP12537
Target Name Sorting nexin-15 (SNX15)
Gene Name SNX15
Gene ID 29907
Synonyms
Sorting nexin-15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLQDPDSDQPLNSLDVKPLRKPRIPMETFRKVGIPIIIALLSLASIIIVVVLIKVILDKY
YFLCGQPLHFIPRKQLCDGELDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSAT
GNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEIGPDQDLDVVEITENSQELRMRNSS
GPCLSGSLVSLHCLACGKSLKTPRVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWV
LTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPL
TFSGTVRPICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADD
AYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQSDQWHVVGIVSWGYGCGGPSTPGVYT
KVSAYLNWIYNVWKAEL
Target Bioclass
Transporter and channel
Family
Sorting nexin family
Subcellular location
Cytoplasm
Function May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.
Uniprot ID
Q9NRS6
Ensemble ID
ENST00000352068.5
HGNC ID
HGNC:14978

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R67C .
CCK81 SNV: p.R51W .
JHH7 SNV: p.G252A .
MCC13 SNV: p.P151S .
MCC26 SNV: p.E258K .
NCIH2291 SNV: p.A224V .
TOV21G SNV: p.P151H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y64(7.85)  LDD0260  [1]
STPyne
 Probe Info  		K321(3.39); K44(1.22); K6(5.00)  LDD0277  [2]
DBIA
 Probe Info  		C192(0.61)  LDD3367  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
m-APA
 Probe Info  		N.A.  LDD2231  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C192(0.97)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C192(1.16)  LDD1509  [5]
 LDCM0259  AC14 HEK-293T C192(1.08)  LDD1512  [5]
 LDCM0277  AC18 HEK-293T C192(0.92)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C192(0.65)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C192(1.34)  LDD1518  [5]
 LDCM0282  AC22 HEK-293T C192(1.17)  LDD1521  [5]
 LDCM0286  AC26 HEK-293T C192(1.15)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C192(0.92)  LDD1526  [5]
 LDCM0290  AC3 HEK-293T C192(0.82)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C192(1.06)  LDD1530  [5]
 LDCM0295  AC34 HEK-293T C192(1.12)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C192(0.80)  LDD1535  [5]
 LDCM0299  AC38 HEK-293T C192(1.03)  LDD1538  [5]
 LDCM0304  AC42 HEK-293T C192(0.90)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C192(1.07)  LDD1544  [5]
 LDCM0308  AC46 HEK-293T C192(1.18)  LDD1547  [5]
 LDCM0313  AC50 HEK-293T C192(1.11)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C192(1.25)  LDD1553  [5]
 LDCM0317  AC54 HEK-293T C192(1.00)  LDD1556  [5]
 LDCM0321  AC58 HEK-293T C192(1.29)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C192(1.20)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C192(1.33)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C192(0.94)  LDD1565  [5]
 LDCM0368  CL10 HEK-293T C192(1.03)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C192(1.24)  LDD1573  [5]
 LDCM0372  CL103 HEK-293T C192(1.19)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C192(0.94)  LDD1577  [5]
 LDCM0376  CL107 HEK-293T C192(1.49)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C192(1.15)  LDD1581  [5]
 LDCM0381  CL111 HEK-293T C192(1.12)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C192(1.08)  LDD1586  [5]
 LDCM0385  CL115 HEK-293T C192(1.06)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C192(0.95)  LDD1590  [5]
 LDCM0389  CL119 HEK-293T C192(1.27)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C192(1.07)  LDD1595  [5]
 LDCM0394  CL123 HEK-293T C192(1.10)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C192(1.05)  LDD1599  [5]
 LDCM0398  CL127 HEK-293T C192(1.26)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C192(1.13)  LDD1603  [5]
 LDCM0402  CL15 HEK-293T C192(1.24)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C192(1.06)  LDD1607  [5]
 LDCM0405  CL18 HEK-293T C192(1.11)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C192(1.18)  LDD1610  [5]
 LDCM0410  CL22 HEK-293T C192(1.14)  LDD1614  [5]
 LDCM0415  CL27 HEK-293T C192(1.22)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C192(1.20)  LDD1620  [5]
 LDCM0418  CL3 HEK-293T C192(1.32)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C192(1.07)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C192(0.99)  LDD1624  [5]
 LDCM0423  CL34 HEK-293T C192(0.93)  LDD1627  [5]
 LDCM0428  CL39 HEK-293T C192(1.19)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C192(1.21)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C192(1.00)  LDD1634  [5]
 LDCM0432  CL42 HEK-293T C192(1.28)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C192(1.07)  LDD1637  [5]
 LDCM0436  CL46 HEK-293T C192(1.06)  LDD1640  [5]
 LDCM0443  CL52 HEK-293T C192(1.05)  LDD1646  [5]
 LDCM0445  CL54 HEK-293T C192(1.28)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C192(1.01)  LDD1649  [5]
 LDCM0449  CL58 HEK-293T C192(1.35)  LDD1652  [5]
 LDCM0451  CL6 HEK-293T C192(1.27)  LDD1654  [5]
 LDCM0455  CL63 HEK-293T C192(1.37)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C192(1.10)  LDD1659  [5]
 LDCM0458  CL66 HEK-293T C192(1.12)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C192(0.78)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C192(0.70)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C192(1.28)  LDD1666  [5]
 LDCM0469  CL76 HEK-293T C192(1.36)  LDD1672  [5]
 LDCM0471  CL78 HEK-293T C192(1.14)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C192(0.79)  LDD1675  [5]
 LDCM0476  CL82 HEK-293T C192(1.11)  LDD1679  [5]
 LDCM0481  CL87 HEK-293T C192(1.15)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C192(1.02)  LDD1685  [5]
 LDCM0485  CL90 HEK-293T C192(0.87)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C192(0.96)  LDD1689  [5]
 LDCM0489  CL94 HEK-293T C192(1.28)  LDD1692  [5]
 LDCM0494  CL99 HEK-293T C192(1.12)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C192(1.28)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C192(1.12)  LDD1671  [5]
 LDCM0022  KB02 HEK-293T C192(1.01)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C192(1.13)  LDD1497  [5]
 LDCM0024  KB05 NUGC-3 C192(0.61)  LDD3367  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor expression-enhancing protein 6 (REEP6) DP1 family Q96HR9
Prenylated Rab acceptor protein 1 (RABAC1) PRA1 family Q9UI14
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Reticulon-4 (RTN4) . Q9NQC3

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402