Details of the Target

General Information of Target

Target ID LDTP12456
Target Name Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7)
Gene Name ENTPD7
Gene ID 57089
Synonyms
LALP1; Ectonucleoside triphosphate diphosphohydrolase 7; NTPDase 7; EC 3.6.1.15; Lysosomal apyrase-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADEQEIMCKLESIKEIRNKTLQMEKIKARLKAEFEALESEERHLKEYKQEMDLLLQEKM
AHVEELRLIHADINVMENTIKQSENDLNKLLESTRRLHDEYKPLKEHVDALRMTLGLQRL
PDLCEEEEKLSLDYFEKQKAEWQTEPQEPPIPESLAAAAAAAQQLQVARKQDTRQTATFR
QQPPPMKACLSCHQQIHRNAPICPLCKAKSRSRNPKKPKRKQDE
Target Bioclass
Enzyme
Family
GDA1/CD39 NTPase family
Subcellular location
Cytoplasmic vesicle membrane
Function
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Preferentially hydrolyzes nucleoside 5'-triphosphates, with substrate preference for UTP > GTP > CTP. Hydrolyzes ATP and nucleoside diphosphates only to a minor extent.
Uniprot ID
Q9NQZ7
Ensemble ID
ENST00000370489.5
HGNC ID
HGNC:19745

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C296(1.08)  LDD1514  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OEA-DA
 Probe Info  		20.00  LDD0046  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C296(1.03)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C296(1.01)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C296(1.07)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C296(1.14)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C296(1.02)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C296(1.00)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C296(0.94)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C296(1.08)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C296(1.11)  LDD1594  [1]
 LDCM0412  CL24 HEK-293T C296(1.05)  LDD1616  [1]
 LDCM0425  CL36 HEK-293T C296(1.19)  LDD1629  [1]
 LDCM0438  CL48 HEK-293T C296(1.19)  LDD1642  [1]
 LDCM0452  CL60 HEK-293T C296(1.14)  LDD1655  [1]
 LDCM0465  CL72 HEK-293T C296(0.92)  LDD1668  [1]
 LDCM0478  CL84 HEK-293T C296(1.18)  LDD1681  [1]
 LDCM0491  CL96 HEK-293T C296(1.26)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570