Details of the Target

General Information of Target

Target ID LDTP12368
Target Name Transmembrane protein 138 (TMEM138)
Gene Name TMEM138
Gene ID 51524
Synonyms
Transmembrane protein 138
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDR
IKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSH
CISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILLSWIKKLLESSQ
Target Bioclass
Other
Family
TMEM138 family
Subcellular location
Vacuole membrane
Function Required for ciliogenesis.
Uniprot ID
Q9NPI0
Ensemble ID
ENST00000278826.11
HGNC ID
HGNC:26944

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGROV1 Deletion: p.T81PfsTer4 .
RH30 SNV: p.R161L .
U2OS SNV: p.M59V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C131(0.88)  LDD1094  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C131(0.88)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C131(0.90)  LDD1105  [1]
 LDCM0237  AC12 PaTu 8988t C131(0.99)  LDD1116  [1]
 LDCM0259  AC14 PaTu 8988t C131(1.06)  LDD1138  [1]
 LDCM0270  AC15 PaTu 8988t C131(0.93)  LDD1149  [1]
 LDCM0285  AC25 PaTu 8988t C131(1.34)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C131(1.03)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C131(1.13)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C131(1.06)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C131(1.32)  LDD1168  [1]
 LDCM0291  AC30 PaTu 8988t C131(1.10)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C131(1.07)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C131(1.20)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C131(0.99)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C131(1.09)  LDD1174  [1]
 LDCM0308  AC46 PaTu 8988t C131(0.84)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C131(0.95)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C131(0.77)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C131(0.76)  LDD1190  [1]
 LDCM0313  AC50 PaTu 8988t C131(0.82)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C131(0.63)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C131(0.82)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C131(0.78)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C131(0.84)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C131(0.92)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C131(1.12)  LDD1198  [1]
 LDCM0323  AC6 PaTu 8988t C131(0.92)  LDD1202  [1]
 LDCM0334  AC7 PaTu 8988t C131(1.03)  LDD1213  [1]
 LDCM0345  AC8 PaTu 8988t C131(1.09)  LDD1224  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C131(0.91)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C131(0.87)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C131(0.91)  LDD1154  [1]
 LDCM0370  CL101 PaTu 8988t C131(1.09)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C131(1.03)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C131(0.92)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C131(1.02)  LDD1252  [1]
 LDCM0382  CL112 PaTu 8988t C131(1.16)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C131(0.99)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C131(1.06)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C131(1.18)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C131(1.14)  LDD1265  [1]
 LDCM0392  CL121 PaTu 8988t C131(0.87)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C131(1.32)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C131(0.77)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C131(0.82)  LDD1274  [1]
 LDCM0420  CL31 PaTu 8988t C131(0.72)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C131(0.66)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C131(0.65)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C131(0.57)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C131(0.68)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C131(0.21)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C131(0.68)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C131(0.68)  LDD1307  [1]
 LDCM0430  CL40 PaTu 8988t C131(0.70)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C131(0.73)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C131(0.69)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C131(0.64)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C131(0.56)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C131(0.56)  LDD1314  [1]
 LDCM0427  Fragment51 PaTu 8988t C131(0.58)  LDD1306  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.