Details of the Target

General Information of Target

Target ID LDTP12244
Target Name Melanoma-associated antigen E1 (MAGEE1)
Gene Name MAGEE1
Gene ID 57692
Synonyms
HCA1; KIAA1587; Melanoma-associated antigen E1; Alpha-dystrobrevin-associated MAGE Protein; DAMAGE; Hepatocellular carcinoma-associated protein 1; MAGE-E1 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAK
RHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEP
EEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQ
SKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKM
IYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIV
SPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLE
SDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGL
HSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGS
SRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVS
TVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLS
SSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADV
KKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWH
RDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVP
EPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTN
PIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDST
SEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK
Target Bioclass
Other
Subcellular location
Cytoplasm, perinuclear region
Function
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Uniprot ID
Q9HCI5
Ensemble ID
ENST00000361470.4
HGNC ID
HGNC:24934

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C429(1.08)  LDD1507  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C429(1.08)  LDD1507  [1]
 LDCM0237  AC12 HEK-293T C429(1.35)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C125(0.97)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C429(0.89)  LDD1515  [1]
 LDCM0280  AC20 HEK-293T C429(0.91)  LDD1519  [1]
 LDCM0283  AC23 HEK-293T C125(0.97)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C429(1.16)  LDD1524  [1]
 LDCM0288  AC28 HEK-293T C429(0.93)  LDD1527  [1]
 LDCM0292  AC31 HEK-293T C125(0.96)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C429(1.49)  LDD1533  [1]
 LDCM0297  AC36 HEK-293T C429(1.04)  LDD1536  [1]
 LDCM0300  AC39 HEK-293T C125(1.14)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C429(1.01)  LDD1540  [1]
 LDCM0303  AC41 HEK-293T C429(1.60)  LDD1542  [1]
 LDCM0306  AC44 HEK-293T C429(1.41)  LDD1545  [1]
 LDCM0309  AC47 HEK-293T C125(1.18)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C429(1.26)  LDD1550  [1]
 LDCM0315  AC52 HEK-293T C429(1.05)  LDD1554  [1]
 LDCM0318  AC55 HEK-293T C125(1.10)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C429(1.21)  LDD1559  [1]
 LDCM0324  AC60 HEK-293T C429(0.96)  LDD1563  [1]
 LDCM0327  AC63 HEK-293T C125(0.99)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C125(1.29)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C429(1.36)  LDD1570  [1]
 LDCM0379  CL11 HEK-293T C125(1.10)  LDD1583  [1]
 LDCM0404  CL17 HEK-293T C429(1.42)  LDD1608  [1]
 LDCM0408  CL20 HEK-293T C429(1.35)  LDD1612  [1]
 LDCM0411  CL23 HEK-293T C125(1.06)  LDD1615  [1]
 LDCM0417  CL29 HEK-293T C429(1.00)  LDD1621  [1]
 LDCM0421  CL32 HEK-293T C429(1.16)  LDD1625  [1]
 LDCM0424  CL35 HEK-293T C125(1.08)  LDD1628  [1]
 LDCM0431  CL41 HEK-293T C429(1.05)  LDD1635  [1]
 LDCM0434  CL44 HEK-293T C429(1.57)  LDD1638  [1]
 LDCM0437  CL47 HEK-293T C125(1.18)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C429(1.33)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C429(1.18)  LDD1647  [1]
 LDCM0447  CL56 HEK-293T C429(1.29)  LDD1650  [1]
 LDCM0450  CL59 HEK-293T C125(1.16)  LDD1653  [1]
 LDCM0457  CL65 HEK-293T C429(1.38)  LDD1660  [1]
 LDCM0460  CL68 HEK-293T C429(1.01)  LDD1663  [1]
 LDCM0464  CL71 HEK-293T C125(1.30)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C429(1.20)  LDD1673  [1]
 LDCM0473  CL8 HEK-293T C429(0.61)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C429(0.98)  LDD1677  [1]
 LDCM0477  CL83 HEK-293T C125(0.95)  LDD1680  [1]
 LDCM0483  CL89 HEK-293T C429(1.31)  LDD1686  [1]
 LDCM0487  CL92 HEK-293T C429(0.95)  LDD1690  [1]
 LDCM0490  CL95 HEK-293T C125(1.10)  LDD1693  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Transcription intermediary factor 1-beta (TRIM28) TRIM/RBCC family Q13263
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Colorectal mutant cancer protein (MCC) MCC family P23508
EP300-interacting inhibitor of differentiation 2B (EID2B) . Q96D98

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.