Details of the Target

General Information of Target

Target ID LDTP12200
Target Name Leucine-rich repeat-containing protein 4 (LRRC4)
Gene Name LRRC4
Gene ID 64101
Synonyms
BAG; Leucine-rich repeat-containing protein 4; Brain tumor-associated protein BAG; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRF
HQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLL
AIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAP
LLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTV
VIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMR
RTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
Target Bioclass
Immunoglobulin
Subcellular location
Membrane
Function
Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma.
Uniprot ID
Q9HBW1
Ensemble ID
ENST00000249363.4
HGNC ID
HGNC:15586

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C329(1.07)  LDD1508  [1]
TFBX
 Probe Info  		N.A.  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C329(1.07)  LDD1508  [1]
 LDCM0259  AC14 HEK-293T C329(1.06)  LDD1512  [1]
 LDCM0277  AC18 HEK-293T C329(0.81)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C329(0.94)  LDD1518  [1]
 LDCM0281  AC21 HEK-293T C329(1.17)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C329(1.11)  LDD1521  [1]
 LDCM0286  AC26 HEK-293T C329(0.85)  LDD1525  [1]
 LDCM0289  AC29 HEK-293T C329(1.10)  LDD1528  [1]
 LDCM0291  AC30 HEK-293T C329(0.91)  LDD1530  [1]
 LDCM0295  AC34 HEK-293T C329(0.77)  LDD1534  [1]
 LDCM0298  AC37 HEK-293T C329(1.11)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C329(1.16)  LDD1538  [1]
 LDCM0304  AC42 HEK-293T C329(0.98)  LDD1543  [1]
 LDCM0307  AC45 HEK-293T C329(1.14)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C329(1.04)  LDD1547  [1]
 LDCM0312  AC5 HEK-293T C329(0.88)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C329(0.69)  LDD1552  [1]
 LDCM0316  AC53 HEK-293T C329(1.11)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C329(1.20)  LDD1556  [1]
 LDCM0321  AC58 HEK-293T C329(0.92)  LDD1560  [1]
 LDCM0323  AC6 HEK-293T C329(1.05)  LDD1562  [1]
 LDCM0325  AC61 HEK-293T C329(1.15)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C329(1.03)  LDD1565  [1]
 LDCM0248  AKOS034007472 HEK-293T C329(1.11)  LDD1511  [1]
 LDCM0367  CL1 HEK-293T C329(1.09)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C329(1.04)  LDD1572  [1]
 LDCM0369  CL100 HEK-293T C329(0.81)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C329(0.97)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C329(1.07)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C329(1.26)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C329(1.12)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C329(1.02)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C329(1.55)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C329(1.03)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C329(0.95)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C329(0.95)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C329(1.30)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C329(0.82)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C329(0.70)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C329(1.31)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C329(1.23)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C329(0.77)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C329(1.28)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C329(1.34)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C329(1.06)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C329(1.06)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C329(0.83)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C329(0.84)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C329(1.66)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C329(0.95)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C329(0.90)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C329(0.87)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C329(0.93)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C329(0.79)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C329(0.98)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C329(0.82)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C329(1.06)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C329(1.06)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C329(0.98)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C329(0.83)  LDD1609  [1]
 LDCM0407  CL2 HEK-293T C329(0.99)  LDD1611  [1]
 LDCM0409  CL21 HEK-293T C329(0.97)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C329(1.10)  LDD1614  [1]
 LDCM0413  CL25 HEK-293T C329(0.82)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C329(1.02)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C329(0.93)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C329(1.22)  LDD1620  [1]
 LDCM0418  CL3 HEK-293T C329(0.97)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C329(0.89)  LDD1623  [1]
 LDCM0422  CL33 HEK-293T C329(1.29)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C329(1.06)  LDD1627  [1]
 LDCM0426  CL37 HEK-293T C329(0.93)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C329(1.28)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C329(0.73)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C329(1.10)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C329(0.90)  LDD1636  [1]
 LDCM0435  CL45 HEK-293T C329(1.23)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C329(0.97)  LDD1640  [1]
 LDCM0439  CL49 HEK-293T C329(0.99)  LDD1643  [1]
 LDCM0441  CL50 HEK-293T C329(1.95)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C329(1.01)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C329(1.15)  LDD1648  [1]
 LDCM0448  CL57 HEK-293T C329(1.09)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C329(1.05)  LDD1652  [1]
 LDCM0451  CL6 HEK-293T C329(0.87)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C329(0.93)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C329(1.30)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C329(1.12)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C329(0.87)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C329(0.81)  LDD1661  [1]
 LDCM0461  CL69 HEK-293T C329(1.10)  LDD1664  [1]
 LDCM0463  CL70 HEK-293T C329(1.33)  LDD1666  [1]
 LDCM0466  CL73 HEK-293T C329(1.02)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C329(1.31)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C329(0.80)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C329(0.77)  LDD1674  [1]
 LDCM0475  CL81 HEK-293T C329(1.34)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C329(1.06)  LDD1679  [1]
 LDCM0479  CL85 HEK-293T C329(0.81)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C329(1.26)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C329(1.11)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C329(0.62)  LDD1685  [1]
 LDCM0484  CL9 HEK-293T C329(0.97)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C329(0.74)  LDD1688  [1]
 LDCM0488  CL93 HEK-293T C329(0.99)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C329(1.13)  LDD1692  [1]
 LDCM0492  CL97 HEK-293T C329(0.89)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C329(1.02)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C329(1.24)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C329(1.59)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C329(1.38)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C329(1.07)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Netrin-G1 (NTNG1) . Q9Y2I2
Netrin-G2 (NTNG2) . Q96CW9

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255