Details of the Target

General Information of Target

Target ID LDTP12183
Target Name Gamma-parvin (PARVG)
Gene Name PARVG
Gene ID 64098
Synonyms
Gamma-parvin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
Target Bioclass
Other
Family
Parvin family
Subcellular location
Cell junction, focal adhesion
Function Probably plays a role in the regulation of cell adhesion and cytoskeleton organization.
Uniprot ID
Q9HBI0
Ensemble ID
ENST00000356909.7
HGNC ID
HGNC:14654
ChEMBL ID
CHEMBL5793

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.S130N .
HT115 SNV: p.Y7C .
LNCaP clone FGC SNV: p.K300N .
MEWO Substitution: p.G253N .
NCIH1793 SNV: p.E4V .
RKO SNV: p.L97M .
TE11 SNV: p.E69Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C314(49.13)  LDD0204  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
Compound 10
 Probe Info  		N.A.  LDD2216  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0102  BDHI 8 Jurkat C314(49.13)  LDD0204  [1]
 LDCM0022  KB02 A673 C314(1.51)  LDD2261  [5]
 LDCM0023  KB03 Jurkat C314(48.00)  LDD0209  [1]
 LDCM0024  KB05 MOLM-13 C314(7.26)  LDD3333  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenine nucleotide translocase lysine N-methyltransferase (ANTKMT) ANT/ATPSC lysine N-methyltransferase family Q9BQD7
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Tribbles homolog 2 (TRIB2) CAMK Ser/Thr protein kinase family Q92519
Integrin-linked protein kinase (ILK) TKL Ser/Thr protein kinase family Q13418
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein aristaless-like 4 (ALX4) Paired homeobox family Q9H161
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Homeobox protein MOX-1 (MEOX1) . P50221
Homeobox protein MOX-2 (MEOX2) . P50222
Proto-oncogene c-Rel (REL) . Q04864
Zinc finger protein 426 (ZNF426) . Q9BUY5
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cilia- and flagella-associated protein 53 (CFAP53) CFAP53 family Q96M91
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) GADD45 family P24522
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Cadherin-related family member 3 (CDHR3) . Q6ZTQ4
PDZ and LIM domain protein 7 (PDLIM7) . Q9NR12
SERTA domain-containing protein 2 (SERTAD2) . Q14140
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840