Details of the Target

General Information of Target

Target ID LDTP12160
Target Name Sp110 nuclear body protein (SP110)
Gene Name SP110
Gene ID 3431
Synonyms
Sp110 nuclear body protein; Interferon-induced protein 41/75; Speckled 110 kDa; Transcriptional coactivator Sp110
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF
DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF
AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT
MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL
FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI
IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV
NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS
KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL
PILQPEKPIVLKVHLRDGITSGP
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Uniprot ID
Q9HB58
Ensemble ID
ENST00000258381.11
HGNC ID
HGNC:5401

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.43  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C327(2.70)  LDD0169  [2]
DBIA
 Probe Info  		C55(7.27); C283(5.73)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C461(0.00); C283(0.00); C468(0.00); C588(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C283(0.00); C435(0.00); C588(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C283(0.00); C327(0.00); C435(0.00); C461(0.00)  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
IPM
 Probe Info  		C435(0.00); C461(0.00)  LDD0147  [6]
TFBX
 Probe Info  		C461(0.00); C520(0.00)  LDD0148  [6]
Acrolein
 Probe Info  		H482(0.00); C327(0.00)  LDD0217  [7]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C327(2.70)  LDD0169  [2]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C283(1.04)  LDD1702  [8]
 LDCM0625  F8 Ramos C55(0.73)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C55(1.07)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C55(1.14)  LDD2190  [9]
 LDCM0575  Fragment13 Ramos C55(1.33)  LDD2192  [9]
 LDCM0580  Fragment21 Ramos C55(1.16)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C55(1.17)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C55(1.20)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C55(0.70)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C55(0.46)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C55(1.63)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C55(1.47)  LDD2201  [9]
 LDCM0468  Fragment33 Ramos C55(1.89)  LDD2202  [9]
 LDCM0596  Fragment38 Ramos C55(1.24)  LDD2203  [9]
 LDCM0610  Fragment52 Ramos C55(0.67)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C55(1.00)  LDD2205  [9]
 LDCM0022  KB02 A101D C333(1.81); C474(1.57)  LDD2250  [10]
 LDCM0023  KB03 Jurkat C55(7.27); C283(5.73)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C333(1.18); C474(1.12)  LDD3310  [10]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840