Details of the Target

General Information of Target

Target ID LDTP12122
Target Name Ubiquitin domain-containing protein 1 (UBTD1)
Gene Name UBTD1
Gene ID 80019
Synonyms
Ubiquitin domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLATLARVAALRRTCLFSGRGGGRGLWTGRPQSDMNNIKPLEGVKILDLTRVLAGPFATM
NLGDLGAEVIKVERPGAGDDTRTWGPPFVGTESTYYLSVNRNKKSIAVNIKDPKGVKIIK
ELAAVCDVFVENYVPGKLSAMGLGYEDIDEIAPHIIYCSITGYGQTGPISQRAGYDAVAS
AVSGLMHITGPENGDPVRPGVAMTDLATGLYAYGAIMAGLIQKYKTGKGLFIDCNLLSSQ
VACLSHIAANYLIGQKEAKRWGTAHGSIVPYQAFKTKDGYIVVGAGNNQQFATVCKILDL
PELIDNSKYKTNHLRVHNRKELIKILSERFEEELTSKWLYLFEGSGVPYGPINNMKNVFA
EPQVLHNGLVMEMEHPTVGKISVPGPAVRYSKFKMSEARPPPLLGQHTTHILKEVLRYDD
RAIGELLSAGVVDQHETH
Target Bioclass
Enzyme
Function
May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2.
Uniprot ID
Q9HAC8
Ensemble ID
ENST00000370664.4
HGNC ID
HGNC:25683

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K152(5.56)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C103(3.84)  LDD0171  [2]
DBIA
 Probe Info  		C103(1.06)  LDD1512  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
AOyne
 Probe Info  		14.50  LDD0443  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C103(3.84)  LDD0171  [2]
 LDCM0259  AC14 HEK-293T C103(1.06)  LDD1512  [3]
 LDCM0282  AC22 HEK-293T C103(0.99)  LDD1521  [3]
 LDCM0291  AC30 HEK-293T C103(0.98)  LDD1530  [3]
 LDCM0299  AC38 HEK-293T C103(0.81)  LDD1538  [3]
 LDCM0308  AC46 HEK-293T C103(0.84)  LDD1547  [3]
 LDCM0317  AC54 HEK-293T C103(0.81)  LDD1556  [3]
 LDCM0323  AC6 HEK-293T C103(0.91)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C103(0.82)  LDD1565  [3]
 LDCM0368  CL10 HEK-293T C103(1.07)  LDD1572  [3]
 LDCM0410  CL22 HEK-293T C103(0.83)  LDD1614  [3]
 LDCM0423  CL34 HEK-293T C103(0.89)  LDD1627  [3]
 LDCM0436  CL46 HEK-293T C103(0.81)  LDD1640  [3]
 LDCM0449  CL58 HEK-293T C103(0.73)  LDD1652  [3]
 LDCM0463  CL70 HEK-293T C103(0.66)  LDD1666  [3]
 LDCM0476  CL82 HEK-293T C103(0.93)  LDD1679  [3]
 LDCM0489  CL94 HEK-293T C103(0.89)  LDD1692  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
E3 ubiquitin-protein ligase Midline-1 (MID1) TRIM/RBCC family O15344
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
E3 ubiquitin-protein ligase TRIM50 (TRIM50) TRIM/RBCC family Q86XT4
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Ubiquitin-conjugating enzyme family P61077
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.