Details of the Target

General Information of Target

Target ID LDTP12005
Target Name E3 ubiquitin-protein ligase RNF167 (RNF167)
Gene Name RNF167
Gene ID 26001
Synonyms
RING105; E3 ubiquitin-protein ligase RNF167; EC 2.3.2.27; RING finger protein 167
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWN
EIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYM
HEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGV
KDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVV
VRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMN
DGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAE
ESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKM
PEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGR
CINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTL
PPPPQAPPPNRAPPPSRPPPRPSV
Target Bioclass
Enzyme
Family
Godzilla family
Subcellular location
Lysosome membrane; Cytoplasm, cytosol
Function
E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway. Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1. Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex. Also involved in protein trafficking and localization. Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2. Does not catalyze ubiquitination of GluA1/GRIA1. Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3. Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B. Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18. Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N.
Uniprot ID
Q9H6Y7
Ensemble ID
ENST00000262482.11
HGNC ID
HGNC:24544

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C256(1.11)  LDD3333  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
TFBX
 Probe Info  		C271(0.00); C248(0.00)  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C256(1.05)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C256(0.90)  LDD1510  [5]
 LDCM0278  AC19 HEK-293T C256(0.91)  LDD1517  [5]
 LDCM0280  AC20 HEK-293T C256(0.94)  LDD1519  [5]
 LDCM0287  AC27 HEK-293T C256(1.01)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C256(0.96)  LDD1527  [5]
 LDCM0290  AC3 HEK-293T C256(0.98)  LDD1529  [5]
 LDCM0296  AC35 HEK-293T C256(1.16)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C256(0.97)  LDD1536  [5]
 LDCM0301  AC4 HEK-293T C256(0.82)  LDD1540  [5]
 LDCM0305  AC43 HEK-293T C256(1.12)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C256(0.88)  LDD1545  [5]
 LDCM0314  AC51 HEK-293T C256(1.07)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C256(1.01)  LDD1554  [5]
 LDCM0322  AC59 HEK-293T C256(1.02)  LDD1561  [5]
 LDCM0324  AC60 HEK-293T C256(1.00)  LDD1563  [5]
 LDCM0369  CL100 HEK-293T C256(0.77)  LDD1573  [5]
 LDCM0373  CL104 HEK-293T C256(0.99)  LDD1577  [5]
 LDCM0377  CL108 HEK-293T C256(0.92)  LDD1581  [5]
 LDCM0382  CL112 HEK-293T C256(0.78)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C256(0.95)  LDD1590  [5]
 LDCM0391  CL120 HEK-293T C256(0.98)  LDD1595  [5]
 LDCM0395  CL124 HEK-293T C256(1.09)  LDD1599  [5]
 LDCM0399  CL128 HEK-293T C256(1.01)  LDD1603  [5]
 LDCM0403  CL16 HEK-293T C256(1.17)  LDD1607  [5]
 LDCM0406  CL19 HEK-293T C256(1.09)  LDD1610  [5]
 LDCM0408  CL20 HEK-293T C256(1.10)  LDD1612  [5]
 LDCM0416  CL28 HEK-293T C256(1.06)  LDD1620  [5]
 LDCM0420  CL31 HEK-293T C256(1.18)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C256(0.91)  LDD1625  [5]
 LDCM0429  CL4 HEK-293T C256(1.10)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C256(0.96)  LDD1634  [5]
 LDCM0433  CL43 HEK-293T C256(1.02)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C256(0.88)  LDD1638  [5]
 LDCM0443  CL52 HEK-293T C256(0.97)  LDD1646  [5]
 LDCM0446  CL55 HEK-293T C256(0.99)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C256(1.06)  LDD1650  [5]
 LDCM0456  CL64 HEK-293T C256(0.94)  LDD1659  [5]
 LDCM0459  CL67 HEK-293T C256(1.13)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C256(0.96)  LDD1663  [5]
 LDCM0462  CL7 HEK-293T C256(1.05)  LDD1665  [5]
 LDCM0469  CL76 HEK-293T C256(1.03)  LDD1672  [5]
 LDCM0472  CL79 HEK-293T C256(0.86)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C256(0.99)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C256(0.96)  LDD1677  [5]
 LDCM0482  CL88 HEK-293T C256(1.08)  LDD1685  [5]
 LDCM0486  CL91 HEK-293T C256(0.93)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C256(0.92)  LDD1690  [5]
 LDCM0022  KB02 A101D C248(1.53)  LDD2250  [1]
 LDCM0023  KB03 A101D C248(2.06)  LDD2667  [1]
 LDCM0024  KB05 MOLM-13 C256(1.11)  LDD3333  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-conjugating enzyme E2 K (UBE2K) Ubiquitin-conjugating enzyme family P61086

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402