Details of the Target

General Information of Target

Target ID LDTP11917
Target Name Calsyntenin-2 (CLSTN2)
Gene Name CLSTN2
Gene ID 64084
Synonyms
CS2; Calsyntenin-2; Alcadein-gamma; Alc-gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
Target Bioclass
Other
Family
Calsyntenin family
Subcellular location
Postsynaptic cell membrane
Function
Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane.
Uniprot ID
Q9H4D0
Ensemble ID
ENST00000458420.7
HGNC ID
HGNC:17448

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C402(1.18)  LDD1514  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C402(1.03)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C402(1.04)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C402(1.17)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C402(0.98)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C402(0.93)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C402(1.00)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C402(0.96)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C402(1.18)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C402(1.17)  LDD1594  [1]
 LDCM0412  CL24 HEK-293T C402(1.20)  LDD1616  [1]
 LDCM0425  CL36 HEK-293T C402(0.95)  LDD1629  [1]
 LDCM0438  CL48 HEK-293T C402(1.16)  LDD1642  [1]
 LDCM0452  CL60 HEK-293T C402(1.03)  LDD1655  [1]
 LDCM0465  CL72 HEK-293T C402(1.06)  LDD1668  [1]
 LDCM0478  CL84 HEK-293T C402(1.36)  LDD1681  [1]
 LDCM0491  CL96 HEK-293T C402(1.23)  LDD1694  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402