Details of the Target

General Information of Target

Target ID LDTP11669
Target Name Linker for activation of T-cells family member 2 (LAT2)
Gene Name LAT2
Gene ID 7462
Synonyms
LAB; NTAL; WBS15; WBSCR15; WBSCR5; Linker for activation of T-cells family member 2; Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MCSTLKKCGTYRTEVAECHDHGSTFQGRKKGGSSFRDNFDKRSCHYEHGGYERPPSHCQE
NDGSVEMRDVHKDQQLRHTPYSIRCERRMKWHSEDEIRITTWRNRKPPERKMSQNTQDGY
TRNWFKVTIPYGIKYDKAWLMNSIQSHCSDRFTPVDFHYVRNRACFFVQDASAASALKDV
SYKIYDDENQKICIFVNHSTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFD
PDLMGRDIDIILNRRNCMAATLKIIERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKT
LNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRE
LSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQYYSIYDSGDRQGLLGAYHDEAC
FSLAIPFDPKDSAPSSLCKYFEDSRNMKTLKDPYLKGELLRRTKRDIVDSLSALPKTQHD
LSSILVDVWCQTERMLCFSVNGVFKEVEGQSQGSVLAFTRTFIATPGSSSSLCIVNDELF
VRDASPQETQSAFSIPVSTLSSSSEPSLSQEQQEMVQAFSAQSGMKLEWSQKCLQDNEWN
YTRAGQAFTMLQTEGKIPAEAFKQIS
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Uniprot ID
Q9GZY6
Ensemble ID
ENST00000275635.11
HGNC ID
HGNC:12749

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.E204G .
IM95 Deletion: p.R123GfsTer34 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.82  LDD0402  [1]
DBIA
 Probe Info  		C160(2.33)  LDD3333  [2]
IA-alkyne
 Probe Info  		C28(1.58); C142(3.39)  LDD2182  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C28(1.14)  LDD1508  [4]
 LDCM0270  AC15 HEK-293T C28(1.08)  LDD1513  [4]
 LDCM0277  AC18 HEK-293T C28(1.05)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C28(1.09)  LDD1518  [4]
 LDCM0283  AC23 HEK-293T C28(0.95)  LDD1522  [4]
 LDCM0286  AC26 HEK-293T C28(1.08)  LDD1525  [4]
 LDCM0292  AC31 HEK-293T C28(1.00)  LDD1531  [4]
 LDCM0295  AC34 HEK-293T C28(1.13)  LDD1534  [4]
 LDCM0300  AC39 HEK-293T C28(1.00)  LDD1539  [4]
 LDCM0304  AC42 HEK-293T C28(1.13)  LDD1543  [4]
 LDCM0309  AC47 HEK-293T C28(1.09)  LDD1548  [4]
 LDCM0313  AC50 HEK-293T C28(1.14)  LDD1552  [4]
 LDCM0318  AC55 HEK-293T C28(1.07)  LDD1557  [4]
 LDCM0321  AC58 HEK-293T C28(1.05)  LDD1560  [4]
 LDCM0327  AC63 HEK-293T C28(0.95)  LDD1566  [4]
 LDCM0334  AC7 HEK-293T C28(0.96)  LDD1568  [4]
 LDCM0372  CL103 HEK-293T C28(1.07)  LDD1576  [4]
 LDCM0376  CL107 HEK-293T C28(1.07)  LDD1580  [4]
 LDCM0379  CL11 HEK-293T C28(0.72)  LDD1583  [4]
 LDCM0381  CL111 HEK-293T C28(0.98)  LDD1585  [4]
 LDCM0385  CL115 HEK-293T C28(1.01)  LDD1589  [4]
 LDCM0389  CL119 HEK-293T C28(1.03)  LDD1593  [4]
 LDCM0394  CL123 HEK-293T C28(1.03)  LDD1598  [4]
 LDCM0398  CL127 HEK-293T C28(1.06)  LDD1602  [4]
 LDCM0402  CL15 HEK-293T C28(0.96)  LDD1606  [4]
 LDCM0405  CL18 HEK-293T C28(0.97)  LDD1609  [4]
 LDCM0411  CL23 HEK-293T C28(0.80)  LDD1615  [4]
 LDCM0415  CL27 HEK-293T C28(1.03)  LDD1619  [4]
 LDCM0418  CL3 HEK-293T C28(0.88)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C28(1.01)  LDD1623  [4]
 LDCM0424  CL35 HEK-293T C28(0.91)  LDD1628  [4]
 LDCM0428  CL39 HEK-293T C28(0.91)  LDD1632  [4]
 LDCM0432  CL42 HEK-293T C28(0.98)  LDD1636  [4]
 LDCM0437  CL47 HEK-293T C28(0.87)  LDD1641  [4]
 LDCM0445  CL54 HEK-293T C28(1.10)  LDD1648  [4]
 LDCM0450  CL59 HEK-293T C28(0.87)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C28(0.89)  LDD1654  [4]
 LDCM0455  CL63 HEK-293T C28(0.99)  LDD1658  [4]
 LDCM0458  CL66 HEK-293T C28(1.00)  LDD1661  [4]
 LDCM0464  CL71 HEK-293T C28(0.93)  LDD1667  [4]
 LDCM0471  CL78 HEK-293T C28(1.05)  LDD1674  [4]
 LDCM0477  CL83 HEK-293T C28(0.95)  LDD1680  [4]
 LDCM0481  CL87 HEK-293T C28(1.00)  LDD1684  [4]
 LDCM0485  CL90 HEK-293T C28(1.05)  LDD1688  [4]
 LDCM0490  CL95 HEK-293T C28(1.00)  LDD1693  [4]
 LDCM0494  CL99 HEK-293T C28(1.01)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C28(0.96)  LDD1698  [4]
 LDCM0625  F8 Ramos C28(0.73); C142(1.22)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C28(0.81); C160(2.45); C142(2.56)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C160(6.13); C142(5.37)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C142(0.91)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C28(1.15); C160(1.27); C142(1.20)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C28(1.53); C160(0.99); C142(0.92)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C28(1.00); C142(1.64)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C28(1.01); C160(1.37); C142(0.94)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C28(0.34); C142(0.95)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C28(1.06); C160(1.46); C142(0.75)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C28(0.49); C160(0.59); C142(0.45)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C28(0.65); C142(1.50)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C28(0.79); C142(1.26)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C28(1.10); C142(4.34)  LDD2201  [3]
 LDCM0468  Fragment33 HEK-293T C28(0.98)  LDD1671  [4]
 LDCM0596  Fragment38 Ramos C28(0.87); C160(2.87); C142(0.88)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C142(1.31)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C28(2.45); C142(0.69)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C28(0.43)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C28(4.08); C142(1.38)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C160(2.62); C142(1.54)  LDD2188  [3]
 LDCM0022  KB02 HEK-293T C28(0.99)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C28(1.04)  LDD1497  [4]
 LDCM0024  KB05 MOLM-13 C160(2.33)  LDD3333  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402