Details of the Target

General Information of Target

Target ID LDTP11632
Target Name Protein rogdi homolog (ROGDI)
Gene Name ROGDI
Gene ID 79641
Synonyms
Protein rogdi homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPPACGKPQQLNRVVGGEDSTDSE
WPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQK
VGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIHLPPNTHCWISGW
GSIQDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLCAGYLEGERDACLG
DSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEKIVQGVQLRGRAQG
GGALRAPSQGSGAAARS
Target Bioclass
Transcription factor
Family
Rogdi family
Subcellular location
Nucleus envelope
Uniprot ID
Q9GZN7
Ensemble ID
ENST00000322048.12
HGNC ID
HGNC:29478

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C66(0.88)  LDD0531  [1]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [2]
IPM
 Probe Info  		N.A.  LDD0025  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C66(0.88)  LDD0531  [1]
 LDCM0216  AC100 HEK-293T C66(1.42)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C66(1.54)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C66(1.32)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C66(1.15)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C66(1.37)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C66(1.06)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C66(0.91)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C66(1.54)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C66(1.03)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C66(1.00)  LDD0823  [1]
 LDCM0227  AC110 HEK-293T C66(1.43)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C66(0.56)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C66(1.61)  LDD0827  [1]
 LDCM0276  AC17 HCT 116 C66(1.01)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C66(0.85)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C66(1.10)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C66(0.93)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C66(0.99)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C66(0.90)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C66(1.01)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C66(1.09)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C66(0.98)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C66(0.97)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C66(1.27)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C66(1.26)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C66(1.45)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C66(1.05)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C66(0.96)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C66(1.11)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C66(1.15)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C66(0.93)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C66(1.20)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C66(1.19)  LDD0893  [1]
 LDCM0301  AC4 HCT 116 C66(0.87)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C66(0.83)  LDD0629  [1]
 LDCM0332  AC68 HCT 116 C66(0.89)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C66(0.84)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C66(0.99)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C66(0.97)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C66(0.96)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C66(1.06)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C66(1.02)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C66(1.00)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C66(1.03)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C66(1.03)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C66(0.97)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C66(0.91)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C66(1.12)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C66(1.12)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C66(1.00)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C66(1.11)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C66(1.11)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C66(1.13)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C66(1.16)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C66(0.92)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C66(1.06)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C66(1.06)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C66(1.01)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C66(1.18)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C66(1.13)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C66(0.96)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C66(1.31)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C66(1.08)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C66(1.35)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C66(1.28)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C66(1.09)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C66(1.03)  LDD0964  [1]
 LDCM0369  CL100 HCT 116 C66(1.03)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C66(0.86)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C66(0.77)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C66(0.87)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C66(0.79)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C66(0.99)  LDD0695  [1]
 LDCM0380  CL110 HCT 116 C66(1.44)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C66(0.93)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C66(0.87)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C66(1.09)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C66(1.52)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C66(1.24)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C66(1.27)  LDD0984  [1]
 LDCM0420  CL31 HEK-293T C66(1.67)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C66(1.61)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C66(1.24)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C66(1.34)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C66(1.38)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C66(1.57)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C66(2.13)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C66(1.67)  LDD1026  [1]
 LDCM0430  CL40 HEK-293T C66(1.48)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C66(1.30)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C66(1.62)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C66(1.61)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C66(1.23)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C66(1.35)  LDD1033  [1]
 LDCM0486  CL91 HCT 116 C66(0.95)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C66(0.95)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C66(0.86)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C66(1.09)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C66(1.33)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C66(0.90)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C66(0.87)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C66(1.07)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C66(0.97)  LDD0811  [1]
 LDCM0427  Fragment51 HEK-293T C66(1.74)  LDD1025  [1]
 LDCM0022  KB02 BRX211 C66(5.15)  LDD2268  [4]
 LDCM0023  KB03 BRX211 C66(3.98)  LDD2685  [4]
 LDCM0024  KB05 NCI-H146 C66(5.83)  LDD3344  [4]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840