Details of the Target

General Information of Target

Target ID LDTP11630
Target Name Homeobox protein TGIF2 (TGIF2)
Gene Name TGIF2
Gene ID 60436
Synonyms
Homeobox protein TGIF2; 5'-TG-3'-interacting factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPF
QKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQ
AVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLL
TNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYRDMDIAKLKGEENTVMIDYVLPD
FSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVY
SIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAW
EGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI
Target Bioclass
Transcription factor
Family
TALE/TGIF homeobox family
Subcellular location
Nucleus
Function
Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
Uniprot ID
Q9GZN2
Ensemble ID
ENST00000373872.9
HGNC ID
HGNC:15764

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MELJUSO SNV: p.S109T .
OVK18 SNV: p.Q237R .
SW948 SNV: p.F195L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C130(0.98)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C130(0.98)  LDD1507  [1]
 LDCM0226  AC11 HEK-293T C130(1.03)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C130(1.00)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C130(0.85)  LDD1515  [1]
 LDCM0278  AC19 HEK-293T C130(1.05)  LDD1517  [1]
 LDCM0281  AC21 HEK-293T C130(1.09)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C130(0.95)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C130(0.91)  LDD1524  [1]
 LDCM0287  AC27 HEK-293T C130(0.96)  LDD1526  [1]
 LDCM0289  AC29 HEK-293T C130(1.15)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C130(0.98)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C130(0.96)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C130(1.31)  LDD1533  [1]
 LDCM0296  AC35 HEK-293T C130(1.03)  LDD1535  [1]
 LDCM0298  AC37 HEK-293T C130(1.15)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C130(1.06)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C130(0.95)  LDD1542  [1]
 LDCM0305  AC43 HEK-293T C130(1.29)  LDD1544  [1]
 LDCM0307  AC45 HEK-293T C130(0.94)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C130(0.94)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C130(1.04)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C130(0.98)  LDD1551  [1]
 LDCM0314  AC51 HEK-293T C130(0.84)  LDD1553  [1]
 LDCM0316  AC53 HEK-293T C130(1.11)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C130(0.88)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C130(0.95)  LDD1559  [1]
 LDCM0322  AC59 HEK-293T C130(0.92)  LDD1561  [1]
 LDCM0325  AC61 HEK-293T C130(0.99)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C130(1.03)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C130(0.98)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C130(0.93)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C130(0.99)  LDD1570  [1]
 LDCM0369  CL100 HEK-293T C130(0.93)  LDD1573  [1]
 LDCM0371  CL102 HEK-293T C130(0.82)  LDD1575  [1]
 LDCM0373  CL104 HEK-293T C130(0.95)  LDD1577  [1]
 LDCM0375  CL106 HEK-293T C130(1.01)  LDD1579  [1]
 LDCM0377  CL108 HEK-293T C130(0.94)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C130(1.04)  LDD1583  [1]
 LDCM0380  CL110 HEK-293T C130(1.01)  LDD1584  [1]
 LDCM0382  CL112 HEK-293T C130(0.98)  LDD1586  [1]
 LDCM0384  CL114 HEK-293T C130(0.94)  LDD1588  [1]
 LDCM0386  CL116 HEK-293T C130(1.01)  LDD1590  [1]
 LDCM0388  CL118 HEK-293T C130(1.06)  LDD1592  [1]
 LDCM0391  CL120 HEK-293T C130(1.21)  LDD1595  [1]
 LDCM0393  CL122 HEK-293T C130(1.02)  LDD1597  [1]
 LDCM0395  CL124 HEK-293T C130(0.95)  LDD1599  [1]
 LDCM0397  CL126 HEK-293T C130(0.97)  LDD1601  [1]
 LDCM0399  CL128 HEK-293T C130(0.77)  LDD1603  [1]
 LDCM0401  CL14 HEK-293T C130(0.90)  LDD1605  [1]
 LDCM0403  CL16 HEK-293T C130(0.86)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C130(0.92)  LDD1608  [1]
 LDCM0406  CL19 HEK-293T C130(1.16)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C130(0.96)  LDD1611  [1]
 LDCM0409  CL21 HEK-293T C130(1.06)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C130(0.93)  LDD1615  [1]
 LDCM0414  CL26 HEK-293T C130(1.02)  LDD1618  [1]
 LDCM0416  CL28 HEK-293T C130(1.04)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C130(1.09)  LDD1621  [1]
 LDCM0420  CL31 HEK-293T C130(0.74)  LDD1624  [1]
 LDCM0422  CL33 HEK-293T C130(0.92)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C130(0.88)  LDD1628  [1]
 LDCM0429  CL4 HEK-293T C130(1.16)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C130(1.06)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C130(0.73)  LDD1635  [1]
 LDCM0433  CL43 HEK-293T C130(0.99)  LDD1637  [1]
 LDCM0435  CL45 HEK-293T C130(1.20)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C130(1.15)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C130(1.16)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C130(0.97)  LDD1645  [1]
 LDCM0443  CL52 HEK-293T C130(1.24)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C130(0.80)  LDD1647  [1]
 LDCM0446  CL55 HEK-293T C130(1.10)  LDD1649  [1]
 LDCM0448  CL57 HEK-293T C130(1.09)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C130(0.85)  LDD1653  [1]
 LDCM0454  CL62 HEK-293T C130(1.08)  LDD1657  [1]
 LDCM0456  CL64 HEK-293T C130(0.96)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C130(1.08)  LDD1660  [1]
 LDCM0459  CL67 HEK-293T C130(0.82)  LDD1662  [1]
 LDCM0461  CL69 HEK-293T C130(1.11)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C130(1.16)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C130(0.99)  LDD1667  [1]
 LDCM0467  CL74 HEK-293T C130(0.74)  LDD1670  [1]
 LDCM0469  CL76 HEK-293T C130(1.01)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C130(0.96)  LDD1673  [1]
 LDCM0472  CL79 HEK-293T C130(0.86)  LDD1675  [1]
 LDCM0475  CL81 HEK-293T C130(0.97)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C130(1.20)  LDD1680  [1]
 LDCM0480  CL86 HEK-293T C130(1.01)  LDD1683  [1]
 LDCM0482  CL88 HEK-293T C130(1.23)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C130(0.98)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C130(1.18)  LDD1687  [1]
 LDCM0486  CL91 HEK-293T C130(0.80)  LDD1689  [1]
 LDCM0488  CL93 HEK-293T C130(0.86)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C130(1.09)  LDD1693  [1]
 LDCM0493  CL98 HEK-293T C130(0.99)  LDD1696  [1]
 LDCM0427  Fragment51 HEK-293T C130(1.29)  LDD1631  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402