Details of the Target

General Information of Target

Target ID LDTP11565
Target Name Thiamine transporter 2 (SLC19A3)
Gene Name SLC19A3
Gene ID 80704
Synonyms
Thiamine transporter 2; ThTr-2; ThTr2; Solute carrier family 19 member 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKFFQEFKADIKFKSAGPGQKLKESVGEKAHKEKPNQPAPRPPRQGPTNEAQMAAAAAL
ARLEQKQSRAWGPTSQDTIRNQVRKELQAEATVSGSPEAPGTNVVSEPREEGSAHLAVPG
VYFTCPLTGATLRKDQRDACIKEAILLHFSTDPVAASIMKIYTFNKDQDRVKLGVDTIAK
YLDNIHLHPEEEKYRKIKLQNKVFQERINCLEGTHEFFEAIGFQKVLLPAQDQEDPEEFY
VLSETTLAQPQSLERHKEQLLAAEPVRAKLDRQRRVFQPSPLASQFELPGDFFNLTAEEI
KREQRLRSEAVERLSVLRTKAMREKEEQRGLRKYNYTLLRVRLPDGCLLQGTFYARERLG
AVYGFVREALQSDWLPFELLASGGQKLSEDENLALNECGLVPSALLTFSWDMAVLEDIKA
AGAEPDSILKPELLSAIEKLL
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
Subcellular location
Membrane
Function Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity. Mediates H(+)-dependent pyridoxine transport.
TTD ID
T55932
Uniprot ID
Q9BZV2
DrugMap ID
TT9BTWM
Ensemble ID
ENST00000258403.8
HGNC ID
HGNC:16266

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C272(5.41)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C228(1.03)  LDD1513  [2]
 LDCM0283  AC23 HEK-293T C228(1.15)  LDD1522  [2]
 LDCM0292  AC31 HEK-293T C228(0.99)  LDD1531  [2]
 LDCM0300  AC39 HEK-293T C228(1.17)  LDD1539  [2]
 LDCM0309  AC47 HEK-293T C228(1.20)  LDD1548  [2]
 LDCM0318  AC55 HEK-293T C228(1.27)  LDD1557  [2]
 LDCM0327  AC63 HEK-293T C228(1.23)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C228(1.27)  LDD1568  [2]
 LDCM0369  CL100 HEK-293T C228(1.04)  LDD1573  [2]
 LDCM0373  CL104 HEK-293T C228(0.94)  LDD1577  [2]
 LDCM0377  CL108 HEK-293T C228(0.97)  LDD1581  [2]
 LDCM0379  CL11 HEK-293T C228(1.06)  LDD1583  [2]
 LDCM0382  CL112 HEK-293T C228(1.01)  LDD1586  [2]
 LDCM0386  CL116 HEK-293T C228(0.94)  LDD1590  [2]
 LDCM0391  CL120 HEK-293T C228(0.88)  LDD1595  [2]
 LDCM0395  CL124 HEK-293T C228(1.01)  LDD1599  [2]
 LDCM0399  CL128 HEK-293T C228(1.02)  LDD1603  [2]
 LDCM0403  CL16 HEK-293T C228(1.21)  LDD1607  [2]
 LDCM0411  CL23 HEK-293T C228(1.08)  LDD1615  [2]
 LDCM0416  CL28 HEK-293T C228(1.05)  LDD1620  [2]
 LDCM0424  CL35 HEK-293T C228(1.07)  LDD1628  [2]
 LDCM0429  CL4 HEK-293T C228(1.05)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C228(0.94)  LDD1634  [2]
 LDCM0437  CL47 HEK-293T C228(1.25)  LDD1641  [2]
 LDCM0443  CL52 HEK-293T C228(1.02)  LDD1646  [2]
 LDCM0450  CL59 HEK-293T C228(1.23)  LDD1653  [2]
 LDCM0456  CL64 HEK-293T C228(1.07)  LDD1659  [2]
 LDCM0464  CL71 HEK-293T C228(1.24)  LDD1667  [2]
 LDCM0469  CL76 HEK-293T C228(1.03)  LDD1672  [2]
 LDCM0477  CL83 HEK-293T C228(1.14)  LDD1680  [2]
 LDCM0482  CL88 HEK-293T C228(1.11)  LDD1685  [2]
 LDCM0490  CL95 HEK-293T C228(1.07)  LDD1693  [2]
 LDCM0022  KB02 FU-OV-1 C228(0.70)  LDD2328  [1]
 LDCM0023  KB03 OV-90 C272(4.15)  LDD2963  [1]
 LDCM0024  KB05 OV-90 C272(5.41)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402