Details of the Target

General Information of Target

Target ID LDTP11444
Target Name E3 ubiquitin-protein ligase RNF26 (RNF26)
Gene Name RNF26
Gene ID 79102
Synonyms
E3 ubiquitin-protein ligase RNF26; EC 2.3.2.27; RING finger protein 26
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADISLDELIRKRGAAAKGRLNARPGVGGVRSRVGIQQGLLSQSTRTATFQQRFDARQKI
GLSDARLKLGVKDAREKLLQKDARFRIKGKVQDAREMLNSRKQQTTVPQKPRQVADAREK
ISLKRSSPAAFINPPIGTVTPALKLTKTIQVPQQKAMAPLHPHPAGMRINVVNNHQAKQN
LYDLDEDDDGIASVPTKQMKFAASGGFLHHMAGLSSSKLSMSKALPLTKVVQNDAYTAPA
LPSSIRTKALTNMSRTLVNKEEPPKELPAAEPVLSPLEGTKMTVNNLHPRVTEEDIVELF
CVCGALKRARLVHPGVAEVVFVKKDDAITAYKKYNNRCLDGQPMKCNLHMNGNVITSDQP
ILLRLSDSPSMKKESELPRRVNSASSSNPPAEVDPDTILKALFKSSGASVTTQPTEFKIK
L
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Uniprot ID
Q9BY78
Ensemble ID
ENST00000311413.5
HGNC ID
HGNC:14646

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C395(1.93)  LDD3352  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C399(1.44)  LDD1523  [3]
 LDCM0293  AC32 HEK-293T C399(1.12)  LDD1532  [3]
 LDCM0302  AC40 HEK-293T C399(1.09)  LDD1541  [3]
 LDCM0310  AC48 HEK-293T C399(1.06)  LDD1549  [3]
 LDCM0319  AC56 HEK-293T C399(0.83)  LDD1558  [3]
 LDCM0328  AC64 HEK-293T C399(0.93)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C399(1.22)  LDD1569  [3]
 LDCM0275  AKOS034007705 HEK-293T C399(0.89)  LDD1514  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C395(1.24)  LDD1571  [3]
 LDCM0370  CL101 HEK-293T C395(0.95)  LDD1574  [3]
 LDCM0374  CL105 HEK-293T C395(1.07)  LDD1578  [3]
 LDCM0378  CL109 HEK-293T C395(1.13)  LDD1582  [3]
 LDCM0383  CL113 HEK-293T C395(1.03)  LDD1587  [3]
 LDCM0387  CL117 HEK-293T C395(1.18)  LDD1591  [3]
 LDCM0390  CL12 HEK-293T C399(1.45)  LDD1594  [3]
 LDCM0392  CL121 HEK-293T C395(1.21)  LDD1596  [3]
 LDCM0396  CL125 HEK-293T C395(1.00)  LDD1600  [3]
 LDCM0400  CL13 HEK-293T C395(1.14)  LDD1604  [3]
 LDCM0412  CL24 HEK-293T C399(1.14)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C395(1.29)  LDD1617  [3]
 LDCM0425  CL36 HEK-293T C399(1.19)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C395(1.09)  LDD1630  [3]
 LDCM0438  CL48 HEK-293T C399(1.21)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C395(1.03)  LDD1643  [3]
 LDCM0452  CL60 HEK-293T C399(1.02)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C395(1.26)  LDD1656  [3]
 LDCM0465  CL72 HEK-293T C399(1.01)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C395(1.00)  LDD1669  [3]
 LDCM0478  CL84 HEK-293T C399(0.94)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C395(1.17)  LDD1682  [3]
 LDCM0491  CL96 HEK-293T C399(1.02)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C395(0.98)  LDD1695  [3]
 LDCM0022  KB02 A2780 C395(1.58)  LDD2254  [1]
 LDCM0023  KB03 A2780 C395(3.26)  LDD2671  [1]
 LDCM0024  KB05 NCI-H1975 C395(1.93)  LDD3352  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402