Details of the Target

General Information of Target

Target ID LDTP11431
Target Name Protein DGCR6L (DGCR6L)
Gene Name DGCR6L
Gene ID 85359
Synonyms
Protein DGCR6L; DiGeorge syndrome critical region 6-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQGPLLLPGLCFLLSLFGAVTQKTKTSCAKCPPNASCVNNTHCTCNHGYTSGSGQKLFTF
PLETCNDINECTPPYSVYCGFNAVCYNVEGSFYCQCVPGYRLHSGNEQFSNSNENTCQDT
TSSKTTEGRKELQKIVDKFESLLTNQTLWRTEGRQEISSTATTILRDVESKVLETALKDP
EQKVLKIQNDSVAIETQAITDNCSEERKTFNLNVQMNSMDIRCSDIIQGDTQGPSAIAFI
SYSSLGNIINATFFEEMDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTFQHVKMTPSTK
KVFCVYWKSTGQGSQWSRDGCFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVIT
YVGLSVSLLCLLLAALTFLLCKAIRNTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKVLCS
IIAGALHYLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPVGYGVPAVTVA
ISAASWPHLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLVLFILVFWILKRKLSSLNSE
VSTIQNTRMLAFKATAQLFILGCTWCLGLLQVGPAAQVMAYLFTIINSLQGFFIFLVYCL
LSQQVQKQYQKWFREIVKSKSESETYTLSSKMGPDSKPSEGDVFPGQVKRKY
Target Bioclass
Other
Family
Gonadal family
Subcellular location
Nucleus
Function May play a role in neural crest cell migration into the third and fourth pharyngeal pouches.
Uniprot ID
Q9BY27
Ensemble ID
ENST00000248879.8
HGNC ID
HGNC:18551

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C107(1.02)  LDD1514  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0284  AC24 HEK-293T C107(1.18)  LDD1523  [1]
 LDCM0293  AC32 HEK-293T C107(1.00)  LDD1532  [1]
 LDCM0302  AC40 HEK-293T C107(0.98)  LDD1541  [1]
 LDCM0310  AC48 HEK-293T C107(1.34)  LDD1549  [1]
 LDCM0319  AC56 HEK-293T C107(1.17)  LDD1558  [1]
 LDCM0328  AC64 HEK-293T C107(0.86)  LDD1567  [1]
 LDCM0345  AC8 HEK-293T C107(0.57)  LDD1569  [1]
 LDCM0275  AKOS034007705 HEK-293T C107(1.02)  LDD1514  [1]
 LDCM0390  CL12 HEK-293T C107(1.46)  LDD1594  [1]
 LDCM0412  CL24 HEK-293T C107(1.53)  LDD1616  [1]
 LDCM0425  CL36 HEK-293T C107(1.92)  LDD1629  [1]
 LDCM0438  CL48 HEK-293T C107(1.62)  LDD1642  [1]
 LDCM0452  CL60 HEK-293T C107(2.70)  LDD1655  [1]
 LDCM0465  CL72 HEK-293T C107(1.67)  LDD1668  [1]
 LDCM0478  CL84 HEK-293T C107(1.83)  LDD1681  [1]
 LDCM0491  CL96 HEK-293T C107(1.16)  LDD1694  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
POU domain class 2-associating factor 1 (POU2AF1) POU2AF family Q16633
High mobility group protein 20A (HMG20A) . Q9NP66
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Deuterosome assembly protein 1 (DEUP1) CEP63 family Q05D60
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
LIM domain-binding protein 2 (LDB2) LDB family O43679
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
SOSS complex subunit C (INIP) SOSS-C family Q9NRY2
Spectrin alpha chain, erythrocytic 1 (SPTA1) Spectrin family P02549
Arginine vasopressin-induced protein 1 (AVPI1) . Q5T686

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402