Details of the Target

General Information of Target

Target ID LDTP11329
Target Name Cell cycle regulator of non-homologous end joining (CYREN)
Gene Name CYREN
Gene ID 78996
Synonyms
C7orf49; MRI; Cell cycle regulator of non-homologous end joining; Cell cycle regulator of NHEJ; Modulator of retrovirus infection homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTDRYTIHSQLEHLQSKYIGTGHADTTKWEWLVNQHRDSYCSYMGHFDLLNYFAIAENES
KARVRFNLMEKMLQPCGPPADKPEEN
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70. In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination. May also act as an indirect regulator of proteasome.
Uniprot ID
Q9BWK5
Ensemble ID
ENST00000393114.8
HGNC ID
HGNC:22432

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
TOV21G SNV: p.M56I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C80(1.93)  LDD3369  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C135(1.19)  LDD0812  [2]
 LDCM0246  AC128 HEK-293T C135(1.14)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C135(1.09)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C135(1.13)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C135(1.39)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C135(1.21)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C135(1.57)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C135(1.45)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C135(1.43)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C135(1.52)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C135(2.44)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C135(2.46)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C135(1.96)  LDD0856  [2]
 LDCM0260  AC140 HEK-293T C135(1.62)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C135(2.20)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C135(1.68)  LDD0860  [2]
 LDCM0279  AC2 HEK-293T C135(1.46)  LDD0877  [2]
 LDCM0290  AC3 HEK-293T C135(1.27)  LDD0888  [2]
 LDCM0301  AC4 HEK-293T C135(1.52)  LDD0899  [2]
 LDCM0308  AC46 HEK-293T C135(0.91)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C135(1.09)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C135(1.20)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C135(1.00)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C135(1.18)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C135(1.04)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C135(1.16)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C135(1.38)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C135(0.87)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C135(1.65)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C135(1.32)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C135(1.21)  LDD0917  [2]
 LDCM0369  CL100 HEK-293T C135(1.21)  LDD0967  [2]
 LDCM0392  CL121 HEK-293T C135(0.96)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C135(1.32)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C135(1.48)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C135(0.96)  LDD0993  [2]
 LDCM0420  CL31 HEK-293T C135(0.95)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C135(0.91)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C135(1.25)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C135(1.15)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C135(1.05)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C135(1.05)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C135(1.17)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C135(1.89)  LDD1026  [2]
 LDCM0430  CL40 HEK-293T C135(1.37)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C135(2.04)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C135(1.43)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C135(1.72)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C135(1.03)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C135(1.71)  LDD1033  [2]
 LDCM0486  CL91 HEK-293T C135(0.93)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C135(1.38)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C135(1.40)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C135(1.54)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C135(1.69)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C135(1.15)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C135(1.27)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C135(1.18)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C135(1.62)  LDD1092  [2]
 LDCM0427  Fragment51 HEK-293T C135(1.27)  LDD1025  [2]
 LDCM0022  KB02 786-O C80(2.00)  LDD2247  [1]
 LDCM0023  KB03 786-O C80(1.97)  LDD2664  [1]
 LDCM0024  KB05 OAW-42 C80(1.93)  LDD3369  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA excision repair protein ERCC-6-like 2 (ERCC6L2) SNF2/RAD54 helicase family Q5T890
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Muskelin (MKLN1) . Q9UL63

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.