Details of the Target

General Information of Target

Target ID LDTP11189
Target Name Synaptotagmin-11 (SYT11)
Gene Name SYT11
Gene ID 23208
Synonyms
KIAA0080; Synaptotagmin-11; Synaptotagmin XI; SytXI
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASLLGAYPWPEGLECPALDAELSDGQSPPAVPRPPGDKGSESRIRRPMNAFMVWAKDER
KRLAVQNPDLHNAELSKMLGKSWKALTLSQKRPYVDEAERLRLQHMQDYPNYKYRPRRKK
QAKRLCKRVDPGFLLSSLSRDQNALPEKRSGSRGALGEKEDRGEYSPGTALPSLRGCYHE
GPAGGGGGGTPSSVDTYPYGLPTPPEMSPLDVLEPEQTFFSSPCQEEHGHPRRIPHLPGH
PYSPEYAPSPLHCSHPLGSLALGQSPGVSMMSPVPGCPPSPAYYSPATYHPLHSNLQAHL
GQLSPPPEHPGFDALDQLSQVELLGDMDRNEFDQYLNTPGHPDSATGAMALSGHVPVSQV
TPTGPTETSLISVLADATATYYNSYSVS
Target Bioclass
Other
Family
Synaptotagmin family
Subcellular location
Cytoplasmic vesicle membrane
Function
Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane. Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway.
Uniprot ID
Q9BT88
Ensemble ID
ENST00000368324.5
HGNC ID
HGNC:19239

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C415(1.25)  LDD3316  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C118(1.16)  LDD1507  [2]
 LDCM0226  AC11 HEK-293T C415(1.04)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C118(1.20)  LDD1510  [2]
 LDCM0276  AC17 HEK-293T C118(1.17)  LDD1515  [2]
 LDCM0278  AC19 HEK-293T C415(1.03)  LDD1517  [2]
 LDCM0280  AC20 HEK-293T C118(0.96)  LDD1519  [2]
 LDCM0285  AC25 HEK-293T C118(1.20)  LDD1524  [2]
 LDCM0287  AC27 HEK-293T C415(0.98)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C118(0.96)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C415(1.02)  LDD1529  [2]
 LDCM0294  AC33 HEK-293T C118(1.15)  LDD1533  [2]
 LDCM0296  AC35 HEK-293T C415(1.04)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C118(1.20)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C118(1.17)  LDD1540  [2]
 LDCM0303  AC41 HEK-293T C118(1.34)  LDD1542  [2]
 LDCM0305  AC43 HEK-293T C415(1.13)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C118(1.03)  LDD1545  [2]
 LDCM0311  AC49 HEK-293T C118(1.27)  LDD1550  [2]
 LDCM0314  AC51 HEK-293T C415(0.98)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C118(1.09)  LDD1554  [2]
 LDCM0320  AC57 HEK-293T C118(1.06)  LDD1559  [2]
 LDCM0322  AC59 HEK-293T C415(1.08)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C118(1.12)  LDD1563  [2]
 LDCM0356  AKOS034007680 HEK-293T C118(1.12)  LDD1570  [2]
 LDCM0367  CL1 HEK-293T C415(0.95); C118(1.07)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C415(0.96); C118(0.86)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C415(0.86); C118(1.08)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C118(1.13)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C415(1.00); C118(1.03)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C415(0.94); C118(0.91)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C415(0.81); C118(1.11)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C118(1.01)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C415(1.25); C118(1.02)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C415(0.88); C118(0.84)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C415(0.88); C118(0.95)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C118(0.99)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C415(0.99); C118(1.05)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C415(0.90); C118(0.96)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C415(0.97); C118(1.11)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C118(1.12)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C415(1.04); C118(1.00)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C415(0.91); C118(0.85)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C415(0.86); C118(1.11)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C118(1.01)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C415(1.03); C118(1.08)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C415(0.99); C118(0.98)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C415(1.04); C118(1.12)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C118(1.00)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C415(0.98); C118(1.00)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C415(0.96); C118(0.91)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C415(0.96); C118(0.99)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C118(1.00)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C415(1.14); C118(1.04)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C415(0.98); C118(0.91)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C415(0.95); C118(1.16)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C118(1.06)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C415(0.94); C118(1.01)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C415(0.93); C118(0.88)  LDD1607  [2]
 LDCM0404  CL17 HEK-293T C118(1.06)  LDD1608  [2]
 LDCM0406  CL19 HEK-293T C415(1.13)  LDD1610  [2]
 LDCM0407  CL2 HEK-293T C118(1.06)  LDD1611  [2]
 LDCM0408  CL20 HEK-293T C118(1.09)  LDD1612  [2]
 LDCM0413  CL25 HEK-293T C415(0.89); C118(1.03)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C118(0.98)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C415(0.88); C118(1.09)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C415(0.92); C118(0.89)  LDD1620  [2]
 LDCM0417  CL29 HEK-293T C118(1.07)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C415(1.04); C118(0.99)  LDD1622  [2]
 LDCM0420  CL31 HEK-293T C415(1.04)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C118(0.97)  LDD1625  [2]
 LDCM0426  CL37 HEK-293T C415(0.90); C118(0.98)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C415(1.04); C118(1.21)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C415(0.98); C118(0.86)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C415(0.93); C118(0.92)  LDD1634  [2]
 LDCM0431  CL41 HEK-293T C118(1.16)  LDD1635  [2]
 LDCM0433  CL43 HEK-293T C415(1.37)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C118(1.27)  LDD1638  [2]
 LDCM0439  CL49 HEK-293T C415(1.00); C118(1.02)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C118(1.27)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C118(1.17)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C415(0.92); C118(0.87)  LDD1646  [2]
 LDCM0444  CL53 HEK-293T C118(1.19)  LDD1647  [2]
 LDCM0446  CL55 HEK-293T C415(1.03)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C118(1.24)  LDD1650  [2]
 LDCM0453  CL61 HEK-293T C415(0.91); C118(1.00)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C118(1.09)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C415(0.96); C118(1.02)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C415(0.94); C118(0.89)  LDD1659  [2]
 LDCM0457  CL65 HEK-293T C118(1.13)  LDD1660  [2]
 LDCM0459  CL67 HEK-293T C415(1.04)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C118(1.16)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C415(1.09)  LDD1665  [2]
 LDCM0466  CL73 HEK-293T C415(0.87); C118(1.06)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C118(0.87)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C415(0.97); C118(1.01)  LDD1672  [2]
 LDCM0470  CL77 HEK-293T C118(1.17)  LDD1673  [2]
 LDCM0472  CL79 HEK-293T C415(1.12)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C118(1.22)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C118(1.14)  LDD1677  [2]
 LDCM0479  CL85 HEK-293T C415(0.79); C118(1.03)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C118(1.02)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C415(0.97); C118(1.07)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C415(0.91); C118(0.95)  LDD1685  [2]
 LDCM0483  CL89 HEK-293T C118(1.13)  LDD1686  [2]
 LDCM0486  CL91 HEK-293T C415(1.13)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C118(1.02)  LDD1690  [2]
 LDCM0492  CL97 HEK-293T C415(0.88); C118(1.18)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C118(1.13)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C415(0.94); C118(1.12)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C415(0.95); C118(0.97)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C415(0.99); C118(0.97)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C118(0.97)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C118(1.07)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C118(1.04)  LDD1497  [2]
 LDCM0024  KB05 MEL167 C415(1.25)  LDD3316  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402