Details of the Target

General Information of Target

Target ID LDTP11154
Target Name Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein (HERPUD2)
Gene Name HERPUD2
Gene ID 64224
Synonyms
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTEQETLALLEVKRSDSPEKSSPQALVPNGRQPEGEGGAESPGAESLRVGSSAGSPTAIE
GAEDGLDSTVSEAATLPWGTGPQPSAPFPDPPGWRDIEPEPPESEPLTKLEELPEDDANL
LPEKAARAFVPIDLQCIERQPQEDLIVRCEAGEGECRTFMPPRVTHPDPTERKWAEAVVR
PPGCSCGGCGSCGDREWLRAVASVGAALILFPCLLYGAYAFLPFDVPRLPTMSSRLIYTL
RCGVFATFPIVLGILVYGLSLLCFSALRPFGEPRREVEIHRRYVAQSVQLFILYFFNLAV
LSTYLPQDTLKLLPLLTGLFAVSRLIYWLTFAVGRSFRGFGYGLTFLPLLSMLMWNLYYM
FVVEPERMLTATESRLDYPDHARSASDYRPRPWG
Target Bioclass
Other
Subcellular location
Membrane
Function Could be involved in the unfolded protein response (UPR) pathway.
Uniprot ID
Q9BSE4
Ensemble ID
ENST00000311350.8
HGNC ID
HGNC:21915

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C86(2.67); C28(1.00)  LDD3358  [1]
BTD
 Probe Info  		C86(0.83)  LDD2110  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C86(1.09)  LDD1508  [4]
 LDCM0226  AC11 HEK-293T C86(1.34); C28(1.12)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C86(1.15); C28(0.95)  LDD1510  [4]
 LDCM0277  AC18 HEK-293T C86(0.96)  LDD1516  [4]
 LDCM0278  AC19 HEK-293T C86(0.93); C28(0.83)  LDD1517  [4]
 LDCM0279  AC2 HEK-293T C86(1.09)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C86(1.10); C28(1.13)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C86(1.10); C28(1.48)  LDD1520  [4]
 LDCM0286  AC26 HEK-293T C86(1.03)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C86(1.28); C28(0.99)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C86(1.15); C28(1.02)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C86(1.09); C28(1.00)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C86(1.20); C28(1.05)  LDD1529  [4]
 LDCM0295  AC34 HEK-293T C86(1.01)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C86(1.27); C28(0.95)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C86(1.26); C28(1.01)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C86(1.12); C28(1.32)  LDD1537  [4]
 LDCM0301  AC4 HEK-293T C86(1.23); C28(1.30)  LDD1540  [4]
 LDCM0304  AC42 HEK-293T C86(1.05)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C86(1.23); C28(0.97)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C86(1.10); C28(1.15)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C86(1.14); C28(1.02)  LDD1546  [4]
 LDCM0312  AC5 HEK-293T C86(1.26); C28(0.95)  LDD1551  [4]
 LDCM0313  AC50 HEK-293T C86(1.02)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C86(1.17); C28(0.95)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C86(1.18); C28(1.03)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C86(1.14); C28(1.13)  LDD1555  [4]
 LDCM0321  AC58 HEK-293T C86(1.07)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C86(1.26); C28(1.18)  LDD1561  [4]
 LDCM0324  AC60 HEK-293T C86(1.06); C28(1.30)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C86(1.04); C28(1.10)  LDD1564  [4]
 LDCM0248  AKOS034007472 HEK-293T C86(1.12); C28(1.08)  LDD1511  [4]
 LDCM0367  CL1 HEK-293T C86(1.20); C28(1.21)  LDD1571  [4]
 LDCM0369  CL100 HEK-293T C86(1.12)  LDD1573  [4]
 LDCM0370  CL101 HEK-293T C86(1.06); C28(1.12)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C86(1.11)  LDD1575  [4]
 LDCM0372  CL103 HEK-293T C86(1.15)  LDD1576  [4]
 LDCM0373  CL104 HEK-293T C86(1.16)  LDD1577  [4]
 LDCM0374  CL105 HEK-293T C86(1.02); C28(0.93)  LDD1578  [4]
 LDCM0375  CL106 HEK-293T C86(0.97)  LDD1579  [4]
 LDCM0376  CL107 HEK-293T C86(1.16)  LDD1580  [4]
 LDCM0377  CL108 HEK-293T C86(1.17)  LDD1581  [4]
 LDCM0378  CL109 HEK-293T C86(1.04); C28(1.17)  LDD1582  [4]
 LDCM0380  CL110 HEK-293T C86(1.05)  LDD1584  [4]
 LDCM0381  CL111 HEK-293T C86(1.01)  LDD1585  [4]
 LDCM0382  CL112 HEK-293T C86(1.16)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C86(1.14); C28(1.26)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C86(1.05)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C86(1.06)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C86(1.18)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C86(1.09); C28(0.96)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C86(1.07)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C86(1.05)  LDD1593  [4]
 LDCM0391  CL120 HEK-293T C86(1.21)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C86(1.03); C28(1.02)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C86(0.99)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C86(1.01)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C86(1.07)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C86(1.07); C28(1.10)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C86(1.20)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C86(1.02)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C86(1.11)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C86(1.07); C28(1.07)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C86(1.11)  LDD1605  [4]
 LDCM0402  CL15 HEK-293T C86(1.05)  LDD1606  [4]
 LDCM0403  CL16 HEK-293T C86(1.35)  LDD1607  [4]
 LDCM0405  CL18 HEK-293T C86(1.10)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C86(1.17); C28(1.08)  LDD1610  [4]
 LDCM0407  CL2 HEK-293T C86(1.04)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C86(0.92); C28(1.24)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C86(0.85); C28(0.81)  LDD1613  [4]
 LDCM0413  CL25 HEK-293T C86(1.11); C28(0.87)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C86(1.14)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C86(1.12)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C86(1.23)  LDD1620  [4]
 LDCM0418  CL3 HEK-293T C86(1.34)  LDD1622  [4]
 LDCM0419  CL30 HEK-293T C86(0.99)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C86(1.07); C28(0.41)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C86(0.93); C28(1.57)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C86(0.70); C28(0.84)  LDD1626  [4]
 LDCM0426  CL37 HEK-293T C86(1.13); C28(1.36)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C86(1.13)  LDD1632  [4]
 LDCM0429  CL4 HEK-293T C86(1.26)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C86(1.08)  LDD1634  [4]
 LDCM0432  CL42 HEK-293T C86(0.98)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C86(1.00); C28(0.99)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C86(0.91); C28(1.32)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C86(0.84); C28(0.97)  LDD1639  [4]
 LDCM0439  CL49 HEK-293T C86(1.13); C28(1.21)  LDD1643  [4]
 LDCM0441  CL50 HEK-293T C86(1.07)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C86(1.11)  LDD1646  [4]
 LDCM0445  CL54 HEK-293T C86(1.03)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C86(1.04); C28(0.91)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C86(0.88); C28(1.13)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C86(0.90); C28(0.87)  LDD1651  [4]
 LDCM0451  CL6 HEK-293T C86(1.02)  LDD1654  [4]
 LDCM0453  CL61 HEK-293T C86(1.08); C28(1.08)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C86(0.99)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C86(1.15)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C86(1.14)  LDD1659  [4]
 LDCM0458  CL66 HEK-293T C86(1.07)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C86(1.26); C28(1.14)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C86(0.90); C28(0.98)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C86(0.75); C28(1.19)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C86(1.08); C28(0.97)  LDD1665  [4]
 LDCM0466  CL73 HEK-293T C86(1.03); C28(1.12)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C86(1.03)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C86(1.19)  LDD1672  [4]
 LDCM0471  CL78 HEK-293T C86(1.04)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C86(1.13); C28(1.02)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C86(0.82); C28(0.83)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C86(0.90); C28(1.22)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C86(0.76); C28(1.11)  LDD1678  [4]
 LDCM0479  CL85 HEK-293T C86(1.06); C28(1.30)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C86(1.22)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C86(1.09)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C86(1.19)  LDD1685  [4]
 LDCM0484  CL9 HEK-293T C86(0.87); C28(1.01)  LDD1687  [4]
 LDCM0485  CL90 HEK-293T C86(0.92)  LDD1688  [4]
 LDCM0486  CL91 HEK-293T C86(1.07); C28(0.97)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C86(0.88); C28(1.11)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C86(0.82); C28(1.01)  LDD1691  [4]
 LDCM0492  CL97 HEK-293T C86(1.14); C28(1.03)  LDD1695  [4]
 LDCM0493  CL98 HEK-293T C86(1.03)  LDD1696  [4]
 LDCM0494  CL99 HEK-293T C86(1.12)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C86(1.06)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C86(1.07)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C86(1.02)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C86(1.13)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C86(1.15)  LDD1497  [4]
 LDCM0024  KB05 NCI-H2291 C86(2.67); C28(1.00)  LDD3358  [1]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C86(0.83)  LDD2110  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase (ALG10) ALG10 glucosyltransferase family Q5BKT4
Serine palmitoyltransferase small subunit A (SPTSSA) SPTSS family Q969W0
Ubiquitin-conjugating enzyme E2 B (UBE2B) Ubiquitin-conjugating enzyme family P63146
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 (CYB561A3) . Q8NBI2
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Bax inhibitor 1 (TMBIM6) BI1 family P55061
Membrane-spanning 4-domains subfamily A member 13 (MS4A13) MS4A family Q5J8X5
Probable UDP-sugar transporter protein SLC35A4 (SLC35A4) Nucleotide-sugar transporter family Q96G79
Transmembrane protein 144 (TMEM144) TMEM144 family Q7Z5S9
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Transmembrane protein 60 (TMEM60) . Q9H2L4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Taste receptor type 2 member 10 (TAS2R10) G-protein coupled receptor T2R family Q9NYW0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ephrin-A5 (EFNA5) Ephrin family P52803
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8
Immediate early response 3-interacting protein 1 (IER3IP1) YOS1 family Q9Y5U9

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402