Details of the Target

General Information of Target

Target ID LDTP11146
Target Name Latexin (LXN)
Gene Name LXN
Gene ID 56925
Synonyms
Latexin; Endogenous carboxypeptidase inhibitor; ECI; Protein MUM; Tissue carboxypeptidase inhibitor; TCI
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSVSFEDVAVAFTQEEWALLDPSQKNLYRDVMQEIFRNLASVGNKSEDQNIQDDFKNPG
RNLSSHVVERLFEIKEGSQYGETFSQDSNLNLNKKVSTGVKPCECSVCGKVFICHSALHR
HILSHIGNKLFECEECPEKLYHCKQCGKAFISLTSVDRHMVTHTSNGPYKGPVYEKPFDF
PSVFQMPQSTYTGEKTYKCKHCDKAFNYSSYLREHERTHTGEKPYACKKCGKSFTFSSSL
RQHERSHTGEKPYECKECGKAFSRSTYLGIHERTHTGEKPYECIKCGKAFRCSRVLRVHE
RTHSGEKPYECKQCGKAFKYSSNLCEHERTHTGVKPYGCKECGKSFTSSSALRSHERTHT
GEKPYECKKCGKAFSCSSSLRKHERAYMW
Target Bioclass
Other
Family
Protease inhibitor I47 (latexin) family
Subcellular location
Cytoplasm
Function Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation.
Uniprot ID
Q9BS40
Ensemble ID
ENST00000264265.4
HGNC ID
HGNC:13347

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.34  LDD0066  [1]
STPyne
 Probe Info  		K38(7.14)  LDD0277  [2]
Probe 1
 Probe Info  		Y20(11.86); Y23(10.43); Y107(13.09)  LDD3495  [3]
Acrolein
 Probe Info  		N.A.  LDD0221  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0072  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carbonic anhydrase 3 (CA3) Alpha-carbonic anhydrase family P07451
Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1) Cytochrome c oxidase subunit 6A family P12074
Dihydropyrimidine dehydrogenase [NADP(+)] (DPYD) Dihydropyrimidine dehydrogenase family Q12882
E3 ubiquitin-protein ligase TRAIP (TRAIP) TRAIP family Q9BWF2
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Germ cell-specific gene 1-like protein (GSG1L) GSG1 family Q6UXU4
Transmembrane protein 14A (TMEM14A) TMEM14 family Q9Y6G1
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 679 (ZNF679) Krueppel C2H2-type zinc-finger protein family Q8IYX0
Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4) Krueppel C2H2-type zinc-finger protein family Q969J2
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
DnaJ homolog subfamily C member 11 (DNAJC11) DNAJC11 family Q9NVH1
SH3KBP1-binding protein 1 (SHKBP1) KCTD3 family Q8TBC3
Melanoma-associated antigen 8 (MAGEA8) . P43361
Minichromosome maintenance domain-containing protein 2 (MCMDC2) . Q4G0Z9
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C) . Q9UQK1
Sperm-associated antigen 7 (SPAG7) . O75391
Zinc finger CCHC domain-containing protein 17 (ZCCHC17) . Q9NP64

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.