Details of the Target

General Information of Target

Target ID LDTP11027
Target Name Telomerase protein component 1 (TEP1)
Gene Name TEP1
Gene ID 7011
Synonyms
TLP1; TP1; Telomerase protein component 1; Telomerase-associated protein 1; Telomerase protein 1; p240; p80 telomerase homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESS
CPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRE
LGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARL
RRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGE
GDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFE
YDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEI
PGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETN
IRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYN
PLEKKLFAWDNLNMVTYDIKLSKM
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also a component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC.
TTD ID
T22769
Uniprot ID
Q99973
DrugMap ID
TTQGAVX
Ensemble ID
ENST00000262715.10
HGNC ID
HGNC:11726

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 Substitution: p.H1797L .
DU145 SNV: p.P437L; p.A1588V .
EFO27 SNV: p.P588H .
HCT15 SNV: p.R1002H .
HGC27 Deletion: p.V667EfsTer20 .
HT115 SNV: p.R389I; p.D1738N .
HUCCT1 SNV: p.S1457C .
JM1 SNV: p.D1837Y .
JURKAT Deletion: p.P1492LfsTer5
SNV: p.H1571Q		 .
KMCH1 SNV: p.D1863E .
KMS27 SNV: p.T2169N .
KPNYN SNV: p.Q1993Ter .
LNCaP clone FGC SNV: p.E1379G .
LU65 SNV: p.P391L .
MCC13 SNV: p.L1035F .
MEWO SNV: p.L986F; p.S1960A .
MFE319 SNV: p.A930V; p.L1341P; p.S1669P .
NB4 SNV: p.Q1521Ter .
NCIH2286 SNV: p.L1416F .
NCIH716 SNV: p.W2223C .
OVCAR8 SNV: p.S2187T .
OVK18 Deletion: p.F1892SfsTer9 .
PC9 Deletion: .
SNV: p.L2360F		 .
RCC10RGB Deletion: p.A1211PfsTer16 .
SNGM SNV: p.L1255M; p.A1570T .
SNU1 Deletion: p.G1081VfsTer26 .
SUPT1 SNV: p.R1147H .
SW1271 SNV: p.P1599T .
TGBC1TKB SNV: p.K59E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C171(3.07)  LDD0171  [1]
IA-alkyne
 Probe Info  		C171(8.72); C1468(10.69); C149(5.89)  LDD1703  [2]
NAIA_5
 Probe Info  		N.A.  LDD2225  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
TPP-AC
 Probe Info  		N.A.  LDD0427  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C171(3.07)  LDD0171  [1]
 LDCM0632  CL-Sc Hep-G2 C171(0.45)  LDD2227  [3]
 LDCM0022  KB02 T cell C171(8.72); C1468(10.69); C149(5.89)  LDD1703  [2]
 LDCM0024  KB05 T cell C171(5.67); C149(7.13)  LDD1705  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.