Details of the Target

General Information of Target

Target ID LDTP10791
Target Name Lipase maturation factor 1 (LMF1)
Gene Name LMF1
Gene ID 64788
Synonyms
C16orf26; TMEM112; Lipase maturation factor 1; Transmembrane protein 112
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALYYDHQIEAPDAAGSPSFISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVER
PFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLS
GDRLGVLLLWRLDQRGRVQGTPLLKHEYGKHLTHCIFRLPPPGEDLVQLAKAAVSGDEKA
LDMFNWKKSSSGSLLKMGSHEGLLFFVSLMDGTVHYVDEKGKTTQVVSADSTIQMLFYME
KREALVVVTENLRLSLYTVPPEGKAEEVMKVKLSGKTGRRADIALIEGSLLVMAVGEAAL
RFWDIERGENYILSPDEKFGFEKGENMNCVCYCKVKGLLAAGTDRGRVAMWRKVPDFLGS
PGAEGKDRWALQTPTELQGNITQIQWGSRKNLLAVNSVISVAILSERAMSSHFHQQVAAM
QVSPSLLNVCFLSTGVAHSLRTDMHISGVFATKDAVAVWNGRQVAIFELSGAAIRSAGTF
LCETPVLAMHEENVYTVESNRVQVRTWQGTVKQLLLFSETEGNPCFLDICGNFLVVGTDL
AHFKSFDLSRREAKAHCSCRSLAELVPGVGGIASLRCSSSGSTISILPSKADNSPDSKIC
FYDVEMDTVTVFDFKTGQIDRRETLSFNEQETNKSHLFVDEGLKNYVPVNHFWDQSEPRL
FVCEAVQETPRSQPQSANGQPQDGRAGPAADVLILSFFISEEHGFLLHESFPRPATSHSL
LGMEVPYYYFTRKPEEADREDEVEPGCHHIPQMVSRRPLRDFVGLEDCDKATRDAMLHFS
FFVTIGDMDEAFKSIKLIKSEAVWENMARMCVKTQRLDVAKVCLGNMGHARGARALREAE
QEPELEARVAVLATQLGMLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQVAEHHDRVHL
RSTYHRYAGHLEASADCSRALSYYEKSDTHRFEVPRMLSEDLPSLELYVNKMKDKTLWRW
WAQYLESQGEMDAALHYYELARDHFSLVRIHCFQGNVQKAAQIANETGNLAASYHLARQY
ESQEEVGQAVHFYTRAQAFKNAIRLCKENGLDDQLMNLALLSSPEDMIEAARYYEEKGVQ
MDRAVMLYHKAGHFSKALELAFATQQFVALQLIAEDLDETSDPALLARCSDFFIEHSQYE
RAVELLLAARKYQEALQLCLGQNMSITEEMAEKMTVAKDSSDLPEESRRELLEQIADCCM
RQGSYHLATKKYTQAGNKLKAMRALLKSGDTEKITFFASVSRQKEIYIMAANYLQSLDWR
KEPEIMKNIIGFYTKGRALDLLAGFYDACAQVEIDEYQNYDKAHGALTEAYKCLAKAKAK
SPLDQETRLAQLQSRMALVKRFIQARRTYTEDPKESIKQCELLLEEPDLDSTIRIGDVYG
FLVEHYVRKEEYQTAYRFLEEMRRRLPLANMSYYVSPQAVDAVHRGLGLPLPRTVPEQVR
HNSMEDARELDEEVVEEADDDP
Target Bioclass
Other
Family
Lipase maturation factor family
Subcellular location
Endoplasmic reticulum membrane
Function
Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL.
Uniprot ID
Q96S06
Ensemble ID
ENST00000262301.16
HGNC ID
HGNC:14154

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.P197A .
TOV21G SNV: p.W104L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C443(1.08)  LDD1507  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C443(1.08)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C443(1.15)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C443(1.06)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C443(1.08)  LDD1510  [1]
 LDCM0270  AC15 HEK-293T C443(1.03)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C443(1.06)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C443(1.02)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C443(1.21)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C443(1.01)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C443(1.03)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C443(1.02)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C443(1.04)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C443(1.05)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C443(1.02)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C443(1.06)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C443(1.04)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C443(1.06)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C443(1.00)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C443(0.99)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C443(1.06)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C443(1.04)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C443(1.12)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C443(1.09)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C443(1.05)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C443(1.16)  LDD1539  [1]
 LDCM0301  AC4 HEK-293T C443(1.04)  LDD1540  [1]
 LDCM0303  AC41 HEK-293T C443(1.15)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C443(1.17)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C443(1.05)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C443(1.06)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C443(1.08)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C443(0.99)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C443(1.15)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C443(1.04)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C443(1.11)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C443(0.99)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C443(1.03)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C443(1.12)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C443(1.08)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C443(1.12)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C443(1.01)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C443(0.99)  LDD1561  [1]
 LDCM0324  AC60 HEK-293T C443(1.05)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C443(1.09)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C443(1.01)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C443(0.97)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C443(1.02)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C443(1.20)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C443(1.14)  LDD1571  [1]
 LDCM0370  CL101 HEK-293T C443(1.17)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C443(1.10)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C443(1.04)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C443(1.00)  LDD1583  [1]
 LDCM0383  CL113 HEK-293T C443(1.16)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C443(1.20)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C443(1.05)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C443(1.09)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C443(1.18)  LDD1604  [1]
 LDCM0404  CL17 HEK-293T C443(1.29)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C443(1.10)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C443(1.11)  LDD1610  [1]
 LDCM0408  CL20 HEK-293T C443(1.00)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C443(0.99)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C443(0.94)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C443(1.15)  LDD1617  [1]
 LDCM0417  CL29 HEK-293T C443(1.11)  LDD1621  [1]
 LDCM0419  CL30 HEK-293T C443(1.08)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C443(1.10)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C443(1.01)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C443(1.03)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C443(0.88)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C443(1.13)  LDD1630  [1]
 LDCM0431  CL41 HEK-293T C443(1.08)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C443(1.01)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C443(0.98)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C443(0.98)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C443(1.01)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C443(0.85)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C443(1.15)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C443(1.15)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C443(1.27)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C443(1.36)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C443(1.04)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C443(1.02)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C443(1.04)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C443(0.92)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C443(1.22)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C443(1.10)  LDD1656  [1]
 LDCM0457  CL65 HEK-293T C443(1.15)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C443(1.06)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C443(1.02)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C443(1.01)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C443(0.91)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C443(1.04)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C443(0.86)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C443(1.14)  LDD1669  [1]
 LDCM0470  CL77 HEK-293T C443(1.17)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C443(1.08)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C443(1.01)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C443(1.14)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C443(1.01)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C443(0.96)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C443(0.99)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C443(1.14)  LDD1682  [1]
 LDCM0483  CL89 HEK-293T C443(1.01)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C443(0.99)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C443(1.18)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C443(1.03)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C443(1.01)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C443(1.02)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C443(1.03)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C443(1.17)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060