Details of the Target

General Information of Target

Target ID LDTP10600
Target Name Kremen protein 1 (KREMEN1)
Gene Name KREMEN1
Gene ID 83999
Synonyms
KREMEN; KRM1; Kremen protein 1; Dickkopf receptor; Kringle domain-containing transmembrane protein 1; Kringle-containing protein marking the eye and the nose
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQ
KPSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSS
ASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYG
SDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEEVDEDGEEEEEEEEEEE
EEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKE
RKRARGISPIVFDRSGSSASESYAGSEKKHEKLSSSVRAVRKDQTSKLKYVLQDARFFLI
KSNNHENVSLAKAKGVWSTLPVNEKKLNLAFRSARSVILIFSVRESGKFQGFARLSSESH
HGGSPIHWVLPAGMSAKMLGGVFKIDWICRRELPFTKSAHLTNPWNEHKPVKIGRDGQEI
ELECGTQLCLLFPPDESIDLYQVIHKMRHKRRMHSQPRSRGRPSRREPVRDVGRRRPEDY
DIHNSRKKPRIDYPPEFHQRPGYLKDPRYQEVDRRFSGVRRDVFLNGSYNDYVREFHNMG
PPPPWQGMPPYPGMEQPPHHPYYQHHAPPPQAHPPYSGHHPVPHEARYRDKRVHDYDMRV
DDFLRRTQAVVSGRRSRPRERDRERERDRPRDNRRDRERDRGRDRERERERLCDRDRDRG
ERGRYRR
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Uniprot ID
Q96MU8
Ensemble ID
ENST00000327813.9
HGNC ID
HGNC:17550

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C431(1.02)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C431(1.02)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C431(0.93)  LDD1508  [1]
 LDCM0270  AC15 HEK-293T C431(0.99)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C431(1.11)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C431(0.96)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C431(0.90)  LDD1518  [1]
 LDCM0283  AC23 HEK-293T C431(0.98)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C431(1.07)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C431(1.06)  LDD1525  [1]
 LDCM0292  AC31 HEK-293T C431(1.10)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C431(1.15)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C431(1.06)  LDD1534  [1]
 LDCM0300  AC39 HEK-293T C431(1.07)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C431(1.16)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C431(0.97)  LDD1543  [1]
 LDCM0309  AC47 HEK-293T C431(0.99)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C431(0.98)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C431(1.01)  LDD1552  [1]
 LDCM0318  AC55 HEK-293T C431(0.86)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C431(1.06)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C431(0.86)  LDD1560  [1]
 LDCM0327  AC63 HEK-293T C431(1.02)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C431(1.10)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C431(1.03)  LDD1570  [1]
 LDCM0369  CL100 HEK-293T C431(0.95)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C431(0.92)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C431(0.89)  LDD1581  [1]
 LDCM0379  CL11 HEK-293T C431(0.83)  LDD1583  [1]
 LDCM0382  CL112 HEK-293T C431(1.12)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C431(1.28)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C431(0.86)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C431(0.93)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C431(1.14)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C431(1.04)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C431(0.91)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C431(1.20)  LDD1609  [1]
 LDCM0411  CL23 HEK-293T C431(1.04)  LDD1615  [1]
 LDCM0416  CL28 HEK-293T C431(0.71)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C431(0.94)  LDD1621  [1]
 LDCM0419  CL30 HEK-293T C431(0.96)  LDD1623  [1]
 LDCM0424  CL35 HEK-293T C431(0.92)  LDD1628  [1]
 LDCM0429  CL4 HEK-293T C431(1.07)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C431(1.21)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C431(1.32)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C431(1.06)  LDD1636  [1]
 LDCM0437  CL47 HEK-293T C431(0.74)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C431(0.91)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C431(0.95)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C431(1.15)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C431(1.02)  LDD1648  [1]
 LDCM0450  CL59 HEK-293T C431(0.90)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C431(0.85)  LDD1654  [1]
 LDCM0456  CL64 HEK-293T C431(0.66)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C431(1.24)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C431(0.79)  LDD1661  [1]
 LDCM0464  CL71 HEK-293T C431(0.88)  LDD1667  [1]
 LDCM0469  CL76 HEK-293T C431(1.06)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C431(1.02)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C431(0.96)  LDD1674  [1]
 LDCM0477  CL83 HEK-293T C431(1.04)  LDD1680  [1]
 LDCM0482  CL88 HEK-293T C431(1.02)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C431(1.04)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C431(1.00)  LDD1688  [1]
 LDCM0490  CL95 HEK-293T C431(0.79)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402