Details of the Target

General Information of Target

Target ID LDTP10497
Target Name Zinc finger CCCH domain-containing protein 10 (ZC3H10)
Gene Name ZC3H10
Gene ID 84872
Synonyms
ZC3HDC10; Zinc finger CCCH domain-containing protein 10
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASCRAWNLRVLVAVVCGLLTGIILGLGIWRIVIRIQRGKSTSSSSTPTEFCRNGGTWEN
GRCICTEEWKGLRCTIANFCENSTYMGFTFARIPVGRYGPSLQTCGKDTPNAGNPMAVRL
CSLSLYGEIELQKVTIGNCNENLETLEKQVKDVTAPLNNISSEVQILTSDANKLTAENIT
SATRVVGQIFNTSRNASPEAKKVAIVTVSQLLDASEDAFQRVAATANDDALTTLIEQMET
YSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLN
PDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQS
ASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAV
LMTFKKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLI
FNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVT
FTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWE
LDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTS
TKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILY
TVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSP
STEEITLSESDNAKESI
Target Bioclass
Other
Subcellular location
Nucleus
Function
Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA.
Uniprot ID
Q96K80
Ensemble ID
ENST00000257940.7
HGNC ID
HGNC:25893

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C92(1.12)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C92(1.12)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C92(1.21)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C92(1.07)  LDD1509  [1]
 LDCM0237  AC12 HEK-293T C92(0.77)  LDD1510  [1]
 LDCM0259  AC14 HEK-293T C92(0.90)  LDD1512  [1]
 LDCM0276  AC17 HEK-293T C92(1.00)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C92(1.21)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C92(0.69)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C92(1.59)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C92(1.14)  LDD1519  [1]
 LDCM0281  AC21 HEK-293T C92(1.03)  LDD1520  [1]
 LDCM0282  AC22 HEK-293T C92(1.20)  LDD1521  [1]
 LDCM0285  AC25 HEK-293T C92(1.11)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C92(1.31)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C92(0.94)  LDD1526  [1]
 LDCM0288  AC28 HEK-293T C92(0.83)  LDD1527  [1]
 LDCM0289  AC29 HEK-293T C92(1.01)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C92(1.19)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C92(0.87)  LDD1530  [1]
 LDCM0294  AC33 HEK-293T C92(1.02)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C92(0.80)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C92(1.05)  LDD1535  [1]
 LDCM0297  AC36 HEK-293T C92(0.89)  LDD1536  [1]
 LDCM0298  AC37 HEK-293T C92(1.18)  LDD1537  [1]
 LDCM0299  AC38 HEK-293T C92(1.03)  LDD1538  [1]
 LDCM0301  AC4 HEK-293T C92(1.48)  LDD1540  [1]
 LDCM0303  AC41 HEK-293T C92(1.08)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C92(1.20)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C92(1.15)  LDD1544  [1]
 LDCM0306  AC44 HEK-293T C92(0.73)  LDD1545  [1]
 LDCM0307  AC45 HEK-293T C92(1.03)  LDD1546  [1]
 LDCM0308  AC46 HEK-293T C92(0.94)  LDD1547  [1]
 LDCM0311  AC49 HEK-293T C92(1.04)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C92(1.07)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C92(0.98)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C92(1.06)  LDD1553  [1]
 LDCM0315  AC52 HEK-293T C92(1.11)  LDD1554  [1]
 LDCM0316  AC53 HEK-293T C92(1.10)  LDD1555  [1]
 LDCM0317  AC54 HEK-293T C92(1.03)  LDD1556  [1]
 LDCM0320  AC57 HEK-293T C92(1.08)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C92(1.21)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C92(0.99)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C92(0.96)  LDD1562  [1]
 LDCM0324  AC60 HEK-293T C92(0.95)  LDD1563  [1]
 LDCM0325  AC61 HEK-293T C92(1.05)  LDD1564  [1]
 LDCM0326  AC62 HEK-293T C92(0.86)  LDD1565  [1]
 LDCM0248  AKOS034007472 HEK-293T C92(1.07)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C92(1.04)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C92(0.90)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C92(0.43)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C92(1.03)  LDD1574  [1]
 LDCM0371  CL102 HEK-293T C92(1.01)  LDD1575  [1]
 LDCM0372  CL103 HEK-293T C92(1.10)  LDD1576  [1]
 LDCM0374  CL105 HEK-293T C92(1.01)  LDD1578  [1]
 LDCM0375  CL106 HEK-293T C92(1.08)  LDD1579  [1]
 LDCM0376  CL107 HEK-293T C92(0.91)  LDD1580  [1]
 LDCM0378  CL109 HEK-293T C92(1.17)  LDD1582  [1]
 LDCM0380  CL110 HEK-293T C92(1.06)  LDD1584  [1]
 LDCM0381  CL111 HEK-293T C92(1.03)  LDD1585  [1]
 LDCM0383  CL113 HEK-293T C92(0.97)  LDD1587  [1]
 LDCM0384  CL114 HEK-293T C92(0.92)  LDD1588  [1]
 LDCM0385  CL115 HEK-293T C92(1.01)  LDD1589  [1]
 LDCM0387  CL117 HEK-293T C92(1.08)  LDD1591  [1]
 LDCM0388  CL118 HEK-293T C92(1.10)  LDD1592  [1]
 LDCM0389  CL119 HEK-293T C92(1.02)  LDD1593  [1]
 LDCM0392  CL121 HEK-293T C92(1.10)  LDD1596  [1]
 LDCM0393  CL122 HEK-293T C92(1.04)  LDD1597  [1]
 LDCM0394  CL123 HEK-293T C92(1.17)  LDD1598  [1]
 LDCM0396  CL125 HEK-293T C92(1.00)  LDD1600  [1]
 LDCM0397  CL126 HEK-293T C92(1.03)  LDD1601  [1]
 LDCM0398  CL127 HEK-293T C92(1.21)  LDD1602  [1]
 LDCM0400  CL13 HEK-293T C92(0.81)  LDD1604  [1]
 LDCM0401  CL14 HEK-293T C92(1.05)  LDD1605  [1]
 LDCM0402  CL15 HEK-293T C92(0.68)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C92(0.72)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C92(0.78)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C92(0.78)  LDD1610  [1]
 LDCM0407  CL2 HEK-293T C92(1.09)  LDD1611  [1]
 LDCM0408  CL20 HEK-293T C92(0.65)  LDD1612  [1]
 LDCM0409  CL21 HEK-293T C92(0.56)  LDD1613  [1]
 LDCM0410  CL22 HEK-293T C92(0.63)  LDD1614  [1]
 LDCM0413  CL25 HEK-293T C92(0.80)  LDD1617  [1]
 LDCM0414  CL26 HEK-293T C92(1.01)  LDD1618  [1]
 LDCM0415  CL27 HEK-293T C92(1.02)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C92(0.86)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C92(1.00)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C92(0.82)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C92(0.79)  LDD1624  [1]
 LDCM0421  CL32 HEK-293T C92(0.75)  LDD1625  [1]
 LDCM0422  CL33 HEK-293T C92(0.53)  LDD1626  [1]
 LDCM0423  CL34 HEK-293T C92(0.50)  LDD1627  [1]
 LDCM0426  CL37 HEK-293T C92(1.28)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C92(1.01)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C92(0.88)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C92(0.99)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C92(0.86)  LDD1637  [1]
 LDCM0434  CL44 HEK-293T C92(0.67)  LDD1638  [1]
 LDCM0435  CL45 HEK-293T C92(0.63)  LDD1639  [1]
 LDCM0436  CL46 HEK-293T C92(0.52)  LDD1640  [1]
 LDCM0439  CL49 HEK-293T C92(1.17)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C92(0.99)  LDD1644  [1]
 LDCM0441  CL50 HEK-293T C92(1.22)  LDD1645  [1]
 LDCM0444  CL53 HEK-293T C92(0.92)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C92(0.79)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C92(0.84)  LDD1649  [1]
 LDCM0447  CL56 HEK-293T C92(0.76)  LDD1650  [1]
 LDCM0448  CL57 HEK-293T C92(0.62)  LDD1651  [1]
 LDCM0449  CL58 HEK-293T C92(0.55)  LDD1652  [1]
 LDCM0451  CL6 HEK-293T C92(0.75)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C92(1.04)  LDD1656  [1]
 LDCM0454  CL62 HEK-293T C92(1.14)  LDD1657  [1]
 LDCM0455  CL63 HEK-293T C92(1.07)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C92(1.07)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C92(0.85)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C92(0.78)  LDD1662  [1]
 LDCM0460  CL68 HEK-293T C92(0.79)  LDD1663  [1]
 LDCM0461  CL69 HEK-293T C92(0.74)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C92(0.83)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C92(0.80)  LDD1666  [1]
 LDCM0466  CL73 HEK-293T C92(1.03)  LDD1669  [1]
 LDCM0467  CL74 HEK-293T C92(1.05)  LDD1670  [1]
 LDCM0470  CL77 HEK-293T C92(1.07)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C92(1.05)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C92(0.93)  LDD1675  [1]
 LDCM0473  CL8 HEK-293T C92(0.54)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C92(0.70)  LDD1677  [1]
 LDCM0475  CL81 HEK-293T C92(0.76)  LDD1678  [1]
 LDCM0476  CL82 HEK-293T C92(0.67)  LDD1679  [1]
 LDCM0479  CL85 HEK-293T C92(1.21)  LDD1682  [1]
 LDCM0480  CL86 HEK-293T C92(1.34)  LDD1683  [1]
 LDCM0481  CL87 HEK-293T C92(1.14)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C92(1.13)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C92(0.61)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C92(0.85)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C92(0.98)  LDD1689  [1]
 LDCM0487  CL92 HEK-293T C92(0.73)  LDD1690  [1]
 LDCM0488  CL93 HEK-293T C92(0.77)  LDD1691  [1]
 LDCM0489  CL94 HEK-293T C92(0.60)  LDD1692  [1]
 LDCM0492  CL97 HEK-293T C92(0.96)  LDD1695  [1]
 LDCM0493  CL98 HEK-293T C92(0.98)  LDD1696  [1]
 LDCM0494  CL99 HEK-293T C92(1.17)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C92(1.01)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C92(1.23)  LDD1671  [1]
 LDCM0427  Fragment51 HEK-293T C92(1.12)  LDD1631  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine oxidase [copper-containing] (AOC1) Copper/topaquinone oxidase family P19801
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FosB (FOSB) BZIP family P53539
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Forkhead box protein H1 (FOXH1) . O75593
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Other
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Proline-rich protein 20C (PRR20C) PRR20 family P86479
Proline-rich protein 20D (PRR20D) PRR20 family P86480
RNA-binding protein 38 (RBM38) RBM38 family Q9H0Z9
Neuronal calcium sensor 1 (NCS1) Recoverin family P62166
Signal transducing adapter molecule 2 (STAM2) STAM family O75886
Amyloid protein-binding protein 2 (APPBP2) . Q92624
DAZ-associated protein 2 (DAZAP2) . Q15038
Disabled homolog 1 (DAB1) . O75553
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
Protein SPMIP9 (SPMIP9) . Q96LM6
RNA-binding protein with multiple splicing (RBPMS) . Q93062
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402