Details of the Target

General Information of Target

Target ID LDTP10426
Target Name Zinc finger protein 496 (ZNF496)
Gene Name ZNF496
Gene ID 84838
Synonyms
ZKSCAN17; Zinc finger protein 496; Zinc finger protein with KRAB and SCAN domains 17
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREEL
AAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEAPALPFARPPAMSLPLEP
WLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASLRLLAKEHAQALDRA
WPPA
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function DNA-binding transcription factor that can both act as an activator and a repressor.
Uniprot ID
Q96IT1
Ensemble ID
ENST00000294753.8
HGNC ID
HGNC:23713

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.P330S .
CHL1 SNV: p.P184S .
DU4475 SNV: p.R72W .
HT Deletion: p.A387PfsTer68 .
HT115 SNV: p.V156G .
HT3 SNV: p.L270F .
IGROV1 Deletion: p.P217RfsTer10
SNV: p.Y557C		 .
KURAMOCHI SNV: p.T172A .
KYSE30 SNV: p.T172A .
MCC13 SNV: p.S236F
Substitution: p.S40F		 .
MEWO SNV: p.S236F;p.S271F
Substitution: p.Q287Ter		 .
NCIH1944 SNV: p.E290Q .
NCIH3122 Substitution: p.D364F .
PF382 SNV: p.R416H .
SKMEL2 SNV: p.S358F .
SUPT1 SNV: p.G110R .
TOV21G SNV: p.P386H; p.H389N .
U118MG SNV: p.P292T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C525(1.04)  LDD1507  [1]
IPM
 Probe Info  		N.A.  LDD0147  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C525(1.04)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C525(1.23)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C525(1.05)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C525(0.91)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C525(1.08)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C525(1.23)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C525(1.68)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C525(1.02)  LDD1518  [1]
 LDCM0283  AC23 HEK-293T C525(0.96)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C525(1.12)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C525(1.05)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C525(1.13)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C525(0.99)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C525(1.03)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C525(1.17)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C525(1.06)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C525(1.01)  LDD1535  [1]
 LDCM0300  AC39 HEK-293T C525(1.19)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C525(1.08)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C525(1.25)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C525(1.10)  LDD1544  [1]
 LDCM0309  AC47 HEK-293T C525(0.93)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C525(0.99)  LDD1550  [1]
 LDCM0313  AC50 HEK-293T C525(1.04)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C525(1.00)  LDD1553  [1]
 LDCM0318  AC55 HEK-293T C525(1.11)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C525(1.08)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C525(1.04)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C525(0.99)  LDD1561  [1]
 LDCM0327  AC63 HEK-293T C525(1.25)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C525(1.08)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C525(1.11)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C525(0.98)  LDD1571  [1]
 LDCM0369  CL100 HEK-293T C525(1.04)  LDD1573  [1]
 LDCM0370  CL101 HEK-293T C525(1.15)  LDD1574  [1]
 LDCM0372  CL103 HEK-293T C525(1.01)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C525(0.96)  LDD1577  [1]
 LDCM0374  CL105 HEK-293T C525(1.03)  LDD1578  [1]
 LDCM0376  CL107 HEK-293T C525(0.95)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C525(0.91)  LDD1581  [1]
 LDCM0378  CL109 HEK-293T C525(1.01)  LDD1582  [1]
 LDCM0379  CL11 HEK-293T C525(0.99)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C525(1.01)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C525(0.90)  LDD1586  [1]
 LDCM0383  CL113 HEK-293T C525(0.99)  LDD1587  [1]
 LDCM0385  CL115 HEK-293T C525(1.10)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C525(0.96)  LDD1590  [1]
 LDCM0387  CL117 HEK-293T C525(1.10)  LDD1591  [1]
 LDCM0389  CL119 HEK-293T C525(0.92)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C525(1.07)  LDD1595  [1]
 LDCM0392  CL121 HEK-293T C525(1.10)  LDD1596  [1]
 LDCM0394  CL123 HEK-293T C525(1.06)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C525(0.94)  LDD1599  [1]
 LDCM0396  CL125 HEK-293T C525(1.18)  LDD1600  [1]
 LDCM0398  CL127 HEK-293T C525(1.09)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C525(1.07)  LDD1603  [1]
 LDCM0400  CL13 HEK-293T C525(1.29)  LDD1604  [1]
 LDCM0402  CL15 HEK-293T C525(0.81)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C525(0.98)  LDD1607  [1]
 LDCM0404  CL17 HEK-293T C525(1.09)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C525(1.36)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C525(1.18)  LDD1610  [1]
 LDCM0411  CL23 HEK-293T C525(1.07)  LDD1615  [1]
 LDCM0413  CL25 HEK-293T C525(1.08)  LDD1617  [1]
 LDCM0415  CL27 HEK-293T C525(1.05)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C525(1.13)  LDD1620  [1]
 LDCM0417  CL29 HEK-293T C525(1.14)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C525(0.94)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C525(1.08)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C525(1.20)  LDD1624  [1]
 LDCM0424  CL35 HEK-293T C525(1.18)  LDD1628  [1]
 LDCM0426  CL37 HEK-293T C525(1.04)  LDD1630  [1]
 LDCM0428  CL39 HEK-293T C525(1.01)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C525(1.19)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C525(1.02)  LDD1634  [1]
 LDCM0431  CL41 HEK-293T C525(1.20)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C525(0.98)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C525(1.00)  LDD1637  [1]
 LDCM0437  CL47 HEK-293T C525(1.07)  LDD1641  [1]
 LDCM0439  CL49 HEK-293T C525(1.06)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C525(1.24)  LDD1644  [1]
 LDCM0443  CL52 HEK-293T C525(1.15)  LDD1646  [1]
 LDCM0444  CL53 HEK-293T C525(1.12)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C525(0.94)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C525(0.99)  LDD1649  [1]
 LDCM0450  CL59 HEK-293T C525(0.98)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C525(1.24)  LDD1654  [1]
 LDCM0453  CL61 HEK-293T C525(1.04)  LDD1656  [1]
 LDCM0455  CL63 HEK-293T C525(1.00)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C525(1.10)  LDD1659  [1]
 LDCM0457  CL65 HEK-293T C525(1.26)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C525(1.18)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C525(1.22)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C525(1.18)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C525(1.25)  LDD1667  [1]
 LDCM0466  CL73 HEK-293T C525(1.08)  LDD1669  [1]
 LDCM0469  CL76 HEK-293T C525(1.02)  LDD1672  [1]
 LDCM0470  CL77 HEK-293T C525(1.18)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C525(1.01)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C525(1.07)  LDD1675  [1]
 LDCM0477  CL83 HEK-293T C525(0.94)  LDD1680  [1]
 LDCM0479  CL85 HEK-293T C525(1.08)  LDD1682  [1]
 LDCM0481  CL87 HEK-293T C525(1.08)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C525(0.99)  LDD1685  [1]
 LDCM0483  CL89 HEK-293T C525(1.09)  LDD1686  [1]
 LDCM0485  CL90 HEK-293T C525(1.05)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C525(1.13)  LDD1689  [1]
 LDCM0490  CL95 HEK-293T C525(0.76)  LDD1693  [1]
 LDCM0492  CL97 HEK-293T C525(1.09)  LDD1695  [1]
 LDCM0494  CL99 HEK-293T C525(0.99)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C525(1.12)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C525(1.08)  LDD1671  [1]
 LDCM0023  KB03 MDA-MB-231 C6(3.41)  LDD1701  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase RNF8 (RNF8) RNF8 family O76064
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger and SCAN domain-containing protein 21 (ZSCAN21) Krueppel C2H2-type zinc-finger protein family Q9Y5A6
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4) Krueppel C2H2-type zinc-finger protein family Q969J2
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin-C (ARR3) Arrestin family P36575
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
Small ubiquitin-related modifier 3 (SUMO3) Ubiquitin family P55854
PiggyBac transposable element-derived protein 1 (PGBD1) . Q96JS3
SCAN domain-containing protein 1 (SCAND1) . P57086
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761