Details of the Target

General Information of Target

Target ID LDTP10424
Target Name 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL)
Gene Name HPDL
Gene ID 84842
Synonyms
GLOXD1; 4-hydroxyphenylpyruvate dioxygenase-like protein; HPD-like protein; EC 1.13.-.-; Glyoxalase domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEKPSGPIPDMLATAEPSSSETDKEVLSPAVPAAAPSSSMSEEPGPEQAATPPVWERGG
AGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPRRRPPPGKQIPCSSPGCCLSF
PSVRDLAQHLRTHCPPTQSLEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCEN
CLLRFRTHRSLFKHLHVCAEHAQSPAPPPPPALDREPPAPERPPEVDPASAPGLPFPLLE
PFTTPAPAPTGPFLPYLNPAPFGLSPPRLRPFLAAAPGPPASSAAVWKKSQGAGSSPRRP
QGGSDAPSGACR
Target Bioclass
Enzyme
Family
4HPPD family
Subcellular location
Mitochondrion
Function May have dioxygenase activity.
Uniprot ID
Q96IR7
Ensemble ID
ENST00000334815.6
HGNC ID
HGNC:28242

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.62  LDD0403  [1]
DBIA
 Probe Info  		C9(1.99)  LDD3364  [2]
AHL-Pu-1
 Probe Info  		C187(3.65)  LDD0170  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
BTD
 Probe Info  		N.A.  LDD0004  [5]
IPM
 Probe Info  		C168(0.00); C82(0.00)  LDD0025  [6]
JW-RF-010
 Probe Info  		C100(0.00); C168(0.00); C82(0.00)  LDD0026  [6]
TFBX
 Probe Info  		C100(0.00); C82(0.00); C168(0.00)  LDD0027  [6]
Acrolein
 Probe Info  		C100(0.00); C82(0.00)  LDD0217  [7]
Methacrolein
 Probe Info  		C168(0.00); C100(0.00)  LDD0218  [7]
NAIA_5
 Probe Info  		C9(0.00); C168(0.00)  LDD2223  [8]
TER-AC
 Probe Info  		N.A.  LDD0426  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C187(3.65)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C82(2.83)  LDD0171  [3]
 LDCM0156  Aniline NCI-H1299 10.62  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C82(0.00); C168(0.00); C100(0.00)  LDD0222  [7]
 LDCM0107  IAA HeLa C168(0.00); C100(0.00); C82(0.00)  LDD0221  [7]
 LDCM0022  KB02 A2058 C9(1.56)  LDD2253  [2]
 LDCM0023  KB03 A2058 C9(2.03)  LDD2670  [2]
 LDCM0024  KB05 NCI-N87 C9(1.99)  LDD3364  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.