Details of the Target

General Information of Target

Target ID LDTP10356
Target Name Scavenger receptor class F member 2 (SCARF2)
Gene Name SCARF2
Gene ID 91179
Synonyms
SREC2; SREPCR; Scavenger receptor class F member 2; SRECRP-1; Scavenger receptor expressed by endothelial cells 2 protein; SREC-II
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MELATRYQIPKEVADIFNAPSDDEEFVGFRDDVPMETLSSEESCDSFDSLESGKQQDVRF
HSKYFTEELRRIFIEDTDSETEDFAGFTQSDLNGKTNPEVMVVESDLSDDGKASLVSEEE
EDEEEDKATPRRSRSRRSSIGLRVAFQFPTKKLANKPDKNSSSEQLFSSARLQNEKKTIL
ERKKDCRQVIQREDSTSESEDDSRDESQESSDALLKRTMNIKENKAMLAQLLAELNSMPD
FFPVRTPTSASRKKTVRRAFSEGQITRRMNPTRSARPPEKFALENFTVSAAKFAEEFYSF
RRRKTIGGKCREYRRRHRISSFRPVEDITEEDLENVAITVRDKIYDKVLGNTCHQCRQKT
IDTKTVCRNQGCCGVRGQFCGPCLRNRYGEDVRSALLDPDWVCPPCRGICNCSYCRKRDG
RCATGILIHLAKFYGYDNVKEYLESLQKELVEDN
Target Bioclass
Other
Subcellular location
Membrane
Function
Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL).
Uniprot ID
Q96GP6
Ensemble ID
ENST00000622235.5
HGNC ID
HGNC:19869

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C314(9.50); C327(9.50); C318(9.50); C251(4.81)  LDD0080  [1]
IA-alkyne
 Probe Info  		C340(0.00); C109(0.00); C295(0.00)  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C295(1.00)  LDD1509  [4]
 LDCM0237  AC12 HEK-293T C295(1.13); C565(0.97)  LDD1510  [4]
 LDCM0259  AC14 HEK-293T C295(1.07)  LDD1512  [4]
 LDCM0278  AC19 HEK-293T C295(1.96)  LDD1517  [4]
 LDCM0280  AC20 HEK-293T C295(1.32); C565(0.87)  LDD1519  [4]
 LDCM0281  AC21 HEK-293T C295(1.16); C156(1.88)  LDD1520  [4]
 LDCM0282  AC22 HEK-293T C295(1.27)  LDD1521  [4]
 LDCM0287  AC27 HEK-293T C295(1.25)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C295(1.12); C565(0.99)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C295(1.18); C156(1.91)  LDD1528  [4]
 LDCM0290  AC3 HEK-293T C295(1.17)  LDD1529  [4]
 LDCM0291  AC30 HEK-293T C295(1.15)  LDD1530  [4]
 LDCM0296  AC35 HEK-293T C295(1.01)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C295(1.01); C565(1.01)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C295(0.83); C156(1.96)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C295(1.38)  LDD1538  [4]
 LDCM0301  AC4 HEK-293T C295(1.11); C565(1.19)  LDD1540  [4]
 LDCM0305  AC43 HEK-293T C295(1.37)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C295(1.02); C565(1.16)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C295(1.27); C156(2.11)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C295(1.01)  LDD1547  [4]
 LDCM0312  AC5 HEK-293T C295(0.60); C156(1.50)  LDD1551  [4]
 LDCM0314  AC51 HEK-293T C295(1.01)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C295(1.16); C565(1.30)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C295(1.05); C156(1.42)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C295(0.93)  LDD1556  [4]
 LDCM0322  AC59 HEK-293T C295(1.01)  LDD1561  [4]
 LDCM0323  AC6 HEK-293T C295(1.04)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C295(0.94); C565(0.81)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C295(0.94); C156(1.22)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C295(1.09)  LDD1565  [4]
 LDCM0248  AKOS034007472 HEK-293T C295(0.74); C156(1.43)  LDD1511  [4]
 LDCM0367  CL1 HEK-293T C295(1.12); C565(1.02); C156(0.91)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C295(1.22)  LDD1572  [4]
 LDCM0370  CL101 HEK-293T C295(0.89); C565(1.15); C156(1.06)  LDD1574  [4]
 LDCM0372  CL103 HEK-293T C295(0.84)  LDD1576  [4]
 LDCM0374  CL105 HEK-293T C295(1.13); C565(1.03); C156(1.22)  LDD1578  [4]
 LDCM0376  CL107 HEK-293T C295(0.65)  LDD1580  [4]
 LDCM0378  CL109 HEK-293T C295(0.97); C565(0.99); C156(1.08)  LDD1582  [4]
 LDCM0381  CL111 HEK-293T C295(0.97)  LDD1585  [4]
 LDCM0383  CL113 HEK-293T C295(1.16); C565(0.86); C156(1.24)  LDD1587  [4]
 LDCM0385  CL115 HEK-293T C295(1.01)  LDD1589  [4]
 LDCM0387  CL117 HEK-293T C295(1.09); C565(1.12); C156(1.23)  LDD1591  [4]
 LDCM0389  CL119 HEK-293T C295(0.95)  LDD1593  [4]
 LDCM0392  CL121 HEK-293T C295(1.14); C565(0.99); C156(1.21)  LDD1596  [4]
 LDCM0394  CL123 HEK-293T C295(1.06)  LDD1598  [4]
 LDCM0396  CL125 HEK-293T C295(1.19); C565(0.80); C156(0.82)  LDD1600  [4]
 LDCM0398  CL127 HEK-293T C295(1.12)  LDD1602  [4]
 LDCM0400  CL13 HEK-293T C295(1.13); C565(0.87); C156(1.21)  LDD1604  [4]
 LDCM0402  CL15 HEK-293T C295(1.28)  LDD1606  [4]
 LDCM0406  CL19 HEK-293T C295(0.98)  LDD1610  [4]
 LDCM0408  CL20 HEK-293T C295(1.16); C565(1.07)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C295(1.15); C156(1.05)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C295(1.13)  LDD1614  [4]
 LDCM0413  CL25 HEK-293T C295(0.84); C565(0.73); C156(0.94)  LDD1617  [4]
 LDCM0415  CL27 HEK-293T C295(1.08)  LDD1619  [4]
 LDCM0418  CL3 HEK-293T C295(0.76)  LDD1622  [4]
 LDCM0420  CL31 HEK-293T C295(1.24)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C295(1.14); C565(1.07)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C295(0.68); C156(1.14)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C295(1.05)  LDD1627  [4]
 LDCM0426  CL37 HEK-293T C295(0.91); C565(0.97); C156(0.91)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C295(0.78)  LDD1632  [4]
 LDCM0433  CL43 HEK-293T C295(1.09)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C295(0.87); C565(1.19)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C295(0.91); C156(1.17)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C295(1.02)  LDD1640  [4]
 LDCM0439  CL49 HEK-293T C295(1.11); C565(0.90); C156(0.78)  LDD1643  [4]
 LDCM0446  CL55 HEK-293T C295(1.28)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C295(1.10); C565(1.07)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C295(1.28); C156(1.49)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C295(1.09)  LDD1652  [4]
 LDCM0453  CL61 HEK-293T C295(0.48); C565(0.84); C156(1.08)  LDD1656  [4]
 LDCM0455  CL63 HEK-293T C295(0.33)  LDD1658  [4]
 LDCM0459  CL67 HEK-293T C295(1.15)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C295(0.99); C565(1.55)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C295(0.35); C156(1.07)  LDD1664  [4]
 LDCM0462  CL7 HEK-293T C295(0.95)  LDD1665  [4]
 LDCM0463  CL70 HEK-293T C295(1.11)  LDD1666  [4]
 LDCM0466  CL73 HEK-293T C295(0.50); C565(0.88); C156(1.09)  LDD1669  [4]
 LDCM0472  CL79 HEK-293T C295(0.80)  LDD1675  [4]
 LDCM0473  CL8 HEK-293T C295(0.95); C565(1.05)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C295(1.06); C565(0.95)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C295(0.31); C156(1.32)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C295(1.22)  LDD1679  [4]
 LDCM0479  CL85 HEK-293T C295(0.86); C565(0.87); C156(0.98)  LDD1682  [4]
 LDCM0481  CL87 HEK-293T C295(0.59)  LDD1684  [4]
 LDCM0484  CL9 HEK-293T C295(0.92); C156(1.42)  LDD1687  [4]
 LDCM0486  CL91 HEK-293T C295(0.98)  LDD1689  [4]
 LDCM0487  CL92 HEK-293T C295(1.31); C565(1.09)  LDD1690  [4]
 LDCM0488  CL93 HEK-293T C295(0.66); C156(1.04)  LDD1691  [4]
 LDCM0489  CL94 HEK-293T C295(1.26)  LDD1692  [4]
 LDCM0492  CL97 HEK-293T C295(0.75); C565(0.89); C156(1.13)  LDD1695  [4]
 LDCM0494  CL99 HEK-293T C295(0.62)  LDD1697  [4]
 LDCM0495  E2913 HEK-293T C295(0.99)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C295(0.39)  LDD1671  [4]
 LDCM0022  KB02 HCT 116 C314(9.50); C327(9.50); C318(9.50); C251(4.81)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C314(2.64); C327(2.64); C318(2.64); C251(3.53)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C314(3.26); C327(3.26); C318(3.26); C251(2.49)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402