Details of the Target

General Information of Target

Target ID LDTP10223
Target Name StAR-related lipid transfer protein 4 (STARD4)
Gene Name STARD4
Gene ID 134429
Synonyms
StAR-related lipid transfer protein 4; START domain-containing protein 4; StARD4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVLVRRCWGPPLAHGARRGRPSPQWRALARLGWEDCRDSRVREKPPWRVLFFGTDQFAR
EALRALHAARENKEEELIDKLEVVTMPSPSPKGLPVKQYAVQSQLPVYEWPDVGSGEYDV
GVVASFGRLLNEALILKFPYGILNVHPSCLPRWRGPAPVIHTVLHGDTVTGVTIMQIRPK
RFDVGPILKQETVPVPPKSTAKELEAVLSRLGANMLISVLKNLPESLSNGRQQPMEGATY
APKISAGTSCIKWEEQTSEQIFRLYRAIGNIIPLQTLWMANTIKLLDLVEVNSSVLADPK
LTGQALIPGSVIYHKQSQILLVYCKDGWIGVRSVMLKKSLTATDFYNGYLHPWYQKNSQA
QPSQCRFQTLRLPTKKKQKKTVAMQQCIE
Target Bioclass
Other
Function Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.
Uniprot ID
Q96DR4
Ensemble ID
ENST00000296632.8
HGNC ID
HGNC:18058

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.G57S .
MEWO SNV: p.E2K .
SUPT1 SNV: p.M83L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C75(3.08)  LDD3332  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C75(1.12)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C75(1.09)  LDD1510  [3]
 LDCM0270  AC15 HEK-293T C75(0.98)  LDD1513  [3]
 LDCM0278  AC19 HEK-293T C75(0.94)  LDD1517  [3]
 LDCM0280  AC20 HEK-293T C75(1.06)  LDD1519  [3]
 LDCM0283  AC23 HEK-293T C75(0.80)  LDD1522  [3]
 LDCM0287  AC27 HEK-293T C75(0.79)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C75(1.15)  LDD1527  [3]
 LDCM0290  AC3 HEK-293T C75(0.89)  LDD1529  [3]
 LDCM0292  AC31 HEK-293T C75(0.89)  LDD1531  [3]
 LDCM0296  AC35 HEK-293T C75(1.01)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C75(1.08)  LDD1536  [3]
 LDCM0300  AC39 HEK-293T C75(1.07)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C75(1.04)  LDD1540  [3]
 LDCM0305  AC43 HEK-293T C75(1.04)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C75(1.05)  LDD1545  [3]
 LDCM0309  AC47 HEK-293T C75(0.93)  LDD1548  [3]
 LDCM0314  AC51 HEK-293T C75(0.98)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C75(1.05)  LDD1554  [3]
 LDCM0318  AC55 HEK-293T C75(0.86)  LDD1557  [3]
 LDCM0322  AC59 HEK-293T C75(0.92)  LDD1561  [3]
 LDCM0324  AC60 HEK-293T C75(1.22)  LDD1563  [3]
 LDCM0327  AC63 HEK-293T C75(0.92)  LDD1566  [3]
 LDCM0334  AC7 HEK-293T C75(0.93)  LDD1568  [3]
 LDCM0379  CL11 HEK-293T C75(1.03)  LDD1583  [3]
 LDCM0406  CL19 HEK-293T C75(0.82)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C75(0.88)  LDD1612  [3]
 LDCM0411  CL23 HEK-293T C75(0.86)  LDD1615  [3]
 LDCM0420  CL31 HEK-293T C75(0.85)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C75(0.89)  LDD1625  [3]
 LDCM0424  CL35 HEK-293T C75(0.79)  LDD1628  [3]
 LDCM0433  CL43 HEK-293T C75(0.89)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C75(0.90)  LDD1638  [3]
 LDCM0437  CL47 HEK-293T C75(0.79)  LDD1641  [3]
 LDCM0446  CL55 HEK-293T C75(0.88)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C75(0.85)  LDD1650  [3]
 LDCM0450  CL59 HEK-293T C75(0.89)  LDD1653  [3]
 LDCM0459  CL67 HEK-293T C75(0.92)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C75(0.93)  LDD1663  [3]
 LDCM0462  CL7 HEK-293T C75(0.71)  LDD1665  [3]
 LDCM0464  CL71 HEK-293T C75(0.92)  LDD1667  [3]
 LDCM0472  CL79 HEK-293T C75(0.80)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C75(0.81)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C75(0.90)  LDD1677  [3]
 LDCM0477  CL83 HEK-293T C75(0.80)  LDD1680  [3]
 LDCM0486  CL91 HEK-293T C75(0.91)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C75(0.91)  LDD1690  [3]
 LDCM0490  CL95 HEK-293T C75(0.78)  LDD1693  [3]
 LDCM0022  KB02 42-MG-BA C75(2.13)  LDD2244  [1]
 LDCM0023  KB03 A101D C75(2.33)  LDD2667  [1]
 LDCM0024  KB05 MKN45 C75(3.08)  LDD3332  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
Ganglioside-induced differentiation-associated protein 1 (GDAP1) GST superfamily Q8TB36
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402