Details of the Target

General Information of Target

Target ID LDTP10087
Target Name Transmembrane protein 143 (TMEM143)
Gene Name TMEM143
Gene ID 55260
Synonyms
Transmembrane protein 143
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPF
MPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKH
HSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEV
AEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSD
DEPFKPWKGLQTNFRLLKRRLREILQ
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q96AN5
Ensemble ID
ENST00000293261.8
HGNC ID
HGNC:25603

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.E150K .
HCT116 SNV: p.S427N .
Ishikawa (Heraklio) 02 ER SNV: p.V238A .
JURKAT SNV: p.R64H .
LS123 SNV: p.L33M .
MFE319 SNV: p.M51V .
NCIH358 SNV: p.F375C .
OVCAR5 SNV: p.Q451K .
TOV21G SNV: p.K367N; p.L370M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C408(0.92)  LDD3313  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C408(1.08)  LDD1513  [2]
 LDCM0283  AC23 HEK-293T C408(0.95)  LDD1522  [2]
 LDCM0292  AC31 HEK-293T C408(1.04)  LDD1531  [2]
 LDCM0300  AC39 HEK-293T C408(1.09)  LDD1539  [2]
 LDCM0309  AC47 HEK-293T C408(1.06)  LDD1548  [2]
 LDCM0318  AC55 HEK-293T C408(1.00)  LDD1557  [2]
 LDCM0327  AC63 HEK-293T C408(1.02)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C408(1.12)  LDD1568  [2]
 LDCM0367  CL1 HEK-293T C408(1.06)  LDD1571  [2]
 LDCM0369  CL100 HEK-293T C408(0.96)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C408(1.07)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C408(0.92)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C408(1.03)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C408(0.98)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C408(1.01)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C408(1.04)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C408(0.84)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C408(1.05)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C408(1.15)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C408(1.05)  LDD1583  [2]
 LDCM0380  CL110 HEK-293T C408(1.10)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C408(0.96)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C408(1.03)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C408(1.04)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C408(0.95)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C408(1.12)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C408(1.01)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C408(1.14)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C408(0.99)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C408(0.93)  LDD1593  [2]
 LDCM0391  CL120 HEK-293T C408(0.88)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C408(0.99)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C408(1.07)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C408(1.03)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C408(1.02)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C408(1.01)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C408(1.12)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C408(1.11)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C408(1.11)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C408(1.15)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C408(1.19)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C408(0.92)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C408(0.91)  LDD1607  [2]
 LDCM0407  CL2 HEK-293T C408(1.08)  LDD1611  [2]
 LDCM0411  CL23 HEK-293T C408(0.98)  LDD1615  [2]
 LDCM0413  CL25 HEK-293T C408(0.86)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C408(1.18)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C408(0.99)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C408(1.00)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C408(1.09)  LDD1622  [2]
 LDCM0424  CL35 HEK-293T C408(1.04)  LDD1628  [2]
 LDCM0426  CL37 HEK-293T C408(0.99)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C408(0.93)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C408(0.93)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C408(0.92)  LDD1634  [2]
 LDCM0437  CL47 HEK-293T C408(1.05)  LDD1641  [2]
 LDCM0439  CL49 HEK-293T C408(1.03)  LDD1643  [2]
 LDCM0441  CL50 HEK-293T C408(1.05)  LDD1645  [2]
 LDCM0443  CL52 HEK-293T C408(1.08)  LDD1646  [2]
 LDCM0450  CL59 HEK-293T C408(1.02)  LDD1653  [2]
 LDCM0453  CL61 HEK-293T C408(1.19)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C408(1.02)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C408(1.31)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C408(0.99)  LDD1659  [2]
 LDCM0464  CL71 HEK-293T C408(1.08)  LDD1667  [2]
 LDCM0466  CL73 HEK-293T C408(1.11)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C408(1.11)  LDD1670  [2]
 LDCM0469  CL76 HEK-293T C408(1.04)  LDD1672  [2]
 LDCM0477  CL83 HEK-293T C408(0.95)  LDD1680  [2]
 LDCM0479  CL85 HEK-293T C408(1.18)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C408(1.10)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C408(1.25)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C408(1.07)  LDD1685  [2]
 LDCM0490  CL95 HEK-293T C408(0.93)  LDD1693  [2]
 LDCM0492  CL97 HEK-293T C408(1.01)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C408(1.10)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C408(1.16)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C408(1.08)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C408(1.05)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C408(0.93)  LDD1631  [2]
 LDCM0022  KB02 HEK-293T C408(1.08)  LDD1492  [2]
 LDCM0023  KB03 HEK-293T C408(0.86)  LDD1497  [2]
 LDCM0024  KB05 Hs 936.T C408(0.92)  LDD3313  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402