Details of the Target

General Information of Target

Target ID LDTP10082
Target Name SOSS complex subunit B2 (NABP1)
Gene Name NABP1
Gene ID 64859
Synonyms
OBFC2A; SSB2; SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKLTTLPSDFCG
LTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNKLVTLPVSFAQLKNLKWLDLKDNPL
DPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQRAK
EAQERELRKREKAEEKERRRKEYDALKAAKREQEKKPKKEANQAPKSKSGSRPRKPPPRK
HTRSWAVLKLLLLLLLFGVAGGLVACRVTELQQQPLCTSVNTIYDNAVQGLRRHEILQWV
LQTDSQQ
Target Bioclass
Other
Family
SOSS-B family, SOSS-B2 subfamily
Subcellular location
Nucleus
Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Uniprot ID
Q96AH0
Ensemble ID
ENST00000307849.7
HGNC ID
HGNC:26232

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.M140T .
MDAMB468 SNV: p.G155V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C23(2.02)  LDD3313  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C103(1.93)  LDD1093  [3]
 LDCM0279  AC2 PaTu 8988t C103(2.66)  LDD1158  [3]
 LDCM0285  AC25 PaTu 8988t C103(1.26)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C103(1.11)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C103(1.90)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C103(1.37)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C103(1.46)  LDD1168  [3]
 LDCM0290  AC3 PaTu 8988t C103(1.21)  LDD1169  [3]
 LDCM0291  AC30 PaTu 8988t C103(1.16)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C103(1.43)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C103(1.19)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C103(1.80)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C103(1.33)  LDD1174  [3]
 LDCM0296  AC35 PaTu 8988t C103(1.40)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C103(1.84)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C103(1.84)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C103(1.90)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C103(1.89)  LDD1179  [3]
 LDCM0301  AC4 PaTu 8988t C103(1.27)  LDD1180  [3]
 LDCM0302  AC40 PaTu 8988t C103(1.87)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C103(0.94)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C103(1.20)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C103(1.55)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C103(1.44)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C103(1.45)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C103(1.25)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C103(1.28)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C103(2.05)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C103(1.64)  LDD1190  [3]
 LDCM0312  AC5 PaTu 8988t C103(1.64)  LDD1191  [3]
 LDCM0313  AC50 PaTu 8988t C103(1.54)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C103(1.34)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C103(1.60)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C103(2.09)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C103(1.88)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C103(1.23)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C103(1.75)  LDD1198  [3]
 LDCM0369  CL100 PaTu 8988t C103(1.82)  LDD1248  [3]
 LDCM0382  CL112 PaTu 8988t C103(1.13)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C103(0.98)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C103(1.14)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C103(1.25)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C103(1.26)  LDD1265  [3]
 LDCM0387  CL117 PaTu 8988t C103(1.05)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C103(1.38)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C103(1.25)  LDD1268  [3]
 LDCM0391  CL120 PaTu 8988t C103(1.37)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C103(1.46)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C103(1.81)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C103(1.53)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C103(1.71)  LDD1274  [3]
 LDCM0420  CL31 PaTu 8988t C103(1.18)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C103(1.52)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C103(1.36)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C103(1.18)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C103(1.21)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C103(0.58)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C103(1.27)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C103(1.57)  LDD1307  [3]
 LDCM0430  CL40 PaTu 8988t C103(1.14)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C103(1.14)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C103(1.32)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C103(1.19)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C103(1.70)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C103(1.48)  LDD1314  [3]
 LDCM0453  CL61 PaTu 8988t C103(1.40)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C103(0.81)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C103(1.47)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C103(1.14)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C103(0.79)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C103(0.99)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C103(1.29)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C103(1.59)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C103(2.14)  LDD1340  [3]
 LDCM0463  CL70 PaTu 8988t C103(1.78)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C103(0.86)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C103(0.81)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C103(1.28)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C103(1.01)  LDD1346  [3]
 LDCM0486  CL91 PaTu 8988t C103(0.95)  LDD1365  [3]
 LDCM0487  CL92 PaTu 8988t C103(1.24)  LDD1366  [3]
 LDCM0488  CL93 PaTu 8988t C103(2.56)  LDD1367  [3]
 LDCM0489  CL94 PaTu 8988t C103(1.72)  LDD1368  [3]
 LDCM0490  CL95 PaTu 8988t C103(1.81)  LDD1369  [3]
 LDCM0491  CL96 PaTu 8988t C103(1.77)  LDD1370  [3]
 LDCM0492  CL97 PaTu 8988t C103(1.32)  LDD1371  [3]
 LDCM0493  CL98 PaTu 8988t C103(1.91)  LDD1372  [3]
 LDCM0494  CL99 PaTu 8988t C103(1.62)  LDD1373  [3]
 LDCM0468  Fragment33 PaTu 8988t C103(1.02)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C103(1.49)  LDD1306  [3]
 LDCM0022  KB02 769-P C23(0.91)  LDD2246  [1]
 LDCM0023  KB03 769-P C23(0.94)  LDD2663  [1]
 LDCM0024  KB05 Hs 936.T C23(2.02)  LDD3313  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
E3 ubiquitin-protein ligase TRIM7 (TRIM7) TRIM/RBCC family Q9C029
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Transcriptional regulator protein Pur-beta (PURB) PUR DNA-binding protein family Q96QR8
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrator complex subunit 3 (INTS3) Integrator subunit 3 family Q68E01
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
KH domain-containing RNA-binding protein QKI (QKI) . Q96PU8
RNA-binding motif protein, X chromosome (RBMX) . P38159

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.