Details of the Target

General Information of Target

Target ID LDTP10010
Target Name Transmembrane protein 54 (TMEM54)
Gene Name TMEM54
Gene ID 113452
Synonyms
BCLP; CAC1; Transmembrane protein 54; Beta-casein-like protein; Protein CAC-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTSDLFASCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPLYYACLCGHEELVLYLLANGA
RCEANTFDGERCLYGALSDPIRRALRDYKQVTASCRRRDYYDDFLQRLLEQGIHSDVVFV
VHGKPFRVHRCVLGARSAYFANMLDTKWKGKSVVVLRHPLINPVAFGALLQYLYTGRLDI
GVEHVSDCERLAKQCQLWDLLSDLEAKCEKVSEFVASKPGTCVKVLTIEPPPADPRLRED
MALLADCALPPELRGDLWELPFPCPDGFNSCPDICFRVAGCSFLCHKAFFCGRSDYFRAL
LDDHFRESEEPATSGGPPAVTLHGISPDVFTHVLYYMYSDHTELSPEAAYDVLSVADMYL
LPGLKRLCGRSLAQMLDEDTVVGVWRVAKLFRLARLEDQCTEYMAKVIEKLVEREDFVEA
VKEEAAAVAARQETDSIPLVDDIRFHVASTVQTYSAIEEAQQRLRALEDLLVSIGLDC
Target Bioclass
Other
Family
TMEM54 family
Subcellular location
Membrane
Uniprot ID
Q969K7
Ensemble ID
ENST00000329151.5
HGNC ID
HGNC:24143

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MFE319 SNV: p.A78V .
PC3 SNV: p.F133S .
RL SNV: p.T221S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C177(1.10)  LDD1508  [1]
NAIA_5
 Probe Info  		N.A.  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C177(1.10)  LDD1508  [1]
 LDCM0237  AC12 HEK-293T C177(0.94)  LDD1510  [1]
 LDCM0277  AC18 HEK-293T C177(0.97)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C177(1.01)  LDD1518  [1]
 LDCM0280  AC20 HEK-293T C177(0.93)  LDD1519  [1]
 LDCM0286  AC26 HEK-293T C177(1.05)  LDD1525  [1]
 LDCM0288  AC28 HEK-293T C177(0.97)  LDD1527  [1]
 LDCM0295  AC34 HEK-293T C177(1.02)  LDD1534  [1]
 LDCM0297  AC36 HEK-293T C177(0.91)  LDD1536  [1]
 LDCM0301  AC4 HEK-293T C177(1.05)  LDD1540  [1]
 LDCM0304  AC42 HEK-293T C177(1.10)  LDD1543  [1]
 LDCM0306  AC44 HEK-293T C177(0.97)  LDD1545  [1]
 LDCM0313  AC50 HEK-293T C177(1.10)  LDD1552  [1]
 LDCM0315  AC52 HEK-293T C177(0.99)  LDD1554  [1]
 LDCM0321  AC58 HEK-293T C177(0.97)  LDD1560  [1]
 LDCM0324  AC60 HEK-293T C177(0.83)  LDD1563  [1]
 LDCM0632  CL-Sc Hep-G2 C214(5.66)  LDD2227  [2]
 LDCM0369  CL100 HEK-293T C177(1.11)  LDD1573  [1]
 LDCM0372  CL103 HEK-293T C177(1.23)  LDD1576  [1]
 LDCM0373  CL104 HEK-293T C177(1.13)  LDD1577  [1]
 LDCM0376  CL107 HEK-293T C177(0.99)  LDD1580  [1]
 LDCM0377  CL108 HEK-293T C177(0.96)  LDD1581  [1]
 LDCM0381  CL111 HEK-293T C177(0.95)  LDD1585  [1]
 LDCM0382  CL112 HEK-293T C177(1.04)  LDD1586  [1]
 LDCM0385  CL115 HEK-293T C177(1.02)  LDD1589  [1]
 LDCM0386  CL116 HEK-293T C177(1.00)  LDD1590  [1]
 LDCM0389  CL119 HEK-293T C177(0.99)  LDD1593  [1]
 LDCM0391  CL120 HEK-293T C177(1.02)  LDD1595  [1]
 LDCM0394  CL123 HEK-293T C177(1.17)  LDD1598  [1]
 LDCM0395  CL124 HEK-293T C177(1.32)  LDD1599  [1]
 LDCM0398  CL127 HEK-293T C177(0.97)  LDD1602  [1]
 LDCM0399  CL128 HEK-293T C177(1.07)  LDD1603  [1]
 LDCM0402  CL15 HEK-293T C177(1.49)  LDD1606  [1]
 LDCM0403  CL16 HEK-293T C177(1.15)  LDD1607  [1]
 LDCM0405  CL18 HEK-293T C177(1.05)  LDD1609  [1]
 LDCM0408  CL20 HEK-293T C177(1.21)  LDD1612  [1]
 LDCM0415  CL27 HEK-293T C177(0.99)  LDD1619  [1]
 LDCM0416  CL28 HEK-293T C177(0.97)  LDD1620  [1]
 LDCM0418  CL3 HEK-293T C177(1.22)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C177(0.95)  LDD1623  [1]
 LDCM0421  CL32 HEK-293T C177(1.12)  LDD1625  [1]
 LDCM0428  CL39 HEK-293T C177(0.93)  LDD1632  [1]
 LDCM0429  CL4 HEK-293T C177(1.10)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C177(0.99)  LDD1634  [1]
 LDCM0432  CL42 HEK-293T C177(0.99)  LDD1636  [1]
 LDCM0434  CL44 HEK-293T C177(0.93)  LDD1638  [1]
 LDCM0443  CL52 HEK-293T C177(1.20)  LDD1646  [1]
 LDCM0445  CL54 HEK-293T C177(1.27)  LDD1648  [1]
 LDCM0447  CL56 HEK-293T C177(1.02)  LDD1650  [1]
 LDCM0451  CL6 HEK-293T C177(1.13)  LDD1654  [1]
 LDCM0455  CL63 HEK-293T C177(0.92)  LDD1658  [1]
 LDCM0456  CL64 HEK-293T C177(0.94)  LDD1659  [1]
 LDCM0458  CL66 HEK-293T C177(0.96)  LDD1661  [1]
 LDCM0460  CL68 HEK-293T C177(0.99)  LDD1663  [1]
 LDCM0469  CL76 HEK-293T C177(1.06)  LDD1672  [1]
 LDCM0471  CL78 HEK-293T C177(1.00)  LDD1674  [1]
 LDCM0473  CL8 HEK-293T C177(1.70)  LDD1676  [1]
 LDCM0474  CL80 HEK-293T C177(1.06)  LDD1677  [1]
 LDCM0481  CL87 HEK-293T C177(1.05)  LDD1684  [1]
 LDCM0482  CL88 HEK-293T C177(1.23)  LDD1685  [1]
 LDCM0485  CL90 HEK-293T C177(1.64)  LDD1688  [1]
 LDCM0487  CL92 HEK-293T C177(1.10)  LDD1690  [1]
 LDCM0494  CL99 HEK-293T C177(0.99)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C177(0.89)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C177(1.03)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264